Editorial: Shaping Ethical Futures in Brain-Based and Artificial Intelligence Research

Science and Engineering Ethics -     

Enhancing social diffusion theory as a basis for prevention intervention: A conceptual and strategic framework

Social diffusion theory has recently been recognized as a promising approach for large-scale disease prevention and health promotion efforts. This paper describes how principles and tactics from social cognitive theory, operant psychology, social psychology, social marketing, and the overarching stages of change model can be used to further develop the conceptual and strategic (technological) bases of social diffusion theory. Within an integrative framework, we discuss in detail more effective ways to train peer mediators of behavior change as one example of how social diffusion theory can benefit from this conceptual and strategic reformulation. We then further illustrate the use of peer mediators of change in human immunodeficiency virus (HIV) and cancer prevention intervention studies with both interventions training peer mediators to diffuse information, norms, and risk reduction strategies. Although the results of these studies showed reductions in high-risk behaviors across population segments, more closely following the framework discussed in this article should further increase the behavior change potential of future interventions based on social diffusion theory.     

Conditioned Inhibition Produced by Extinction of a Conditioned Stimulus

Four experiments used a conditioned taste aversion procedure to examine the potential for CS-alone extinction treatment to produce a conditioned stimulus that possesses inhibitory properties. In Experiment 1, saccharin was paired with LiCl, and then saccharin was presented alone for several trials to produce extensive behavioral extinction. Animals receiving this treatment were retarded in reacquiring conditioned responding to saccharin relative to control subjects receiving conditioning to the flavor for the first time. In Experiment 2, the extinguished saccharin stimulus was shown to decrease conditioned responding to a known excitor when the two stimuli were presented in compound as a summation test. Experiments 3A and 3B replicated the findings of Experiments 1 and 2 while providing evidence that the effects were not due to the differential effects of neophobia during testing. These three experiments revealed that an extinguished conditioned excitor passes retardation and summation tests for conditioned inhibition. Experiment 4 found that extinction of a known excitor was slowed when the excitor was extinguished in compound with a previously extinguished conditioned stimulus. That is, an extinguished CS provided protection from extinction to another CS, a finding also consistent with the view that extinction produces conditioned inhibition.     

The View from the Driver's Seat: What Good Is Salience?

A set of experiments gauged the value of salient and non‐salient visual information to drivers' decision making. Stimuli were images of traffic scenes viewed from a drivers' approximate perspective, and the subjects' task was to make stop‐or‐go driving judgments. Under some experimental conditions (Experiment 1), subjects viewed only the salient information from within each scene. Under other conditions (Experiments 2–3), they viewed only the non‐salient information. A signal detection measure of sensitivity served as the primary dependent measure. Data indicated that an above‐chance amount of the information needed for accurate judgments was contained within salient image regions and that some information was available only from the salient regions. Other critical information, however, was contained exclusively within non‐salient regions. Results suggest that an attentional bias toward visual salience would serve as an economical information‐seeking strategy for drivers but by itself would overlook many task‐critical cues. Copyright © 2013 John Wiley & Sons, Ltd.     

Out of the depths

A fundamental approach of theology as practiced within the palliative setting is care for the whole human being, with particular focus on spirituality and the spiritual dimension. Theology and medicine come together in palliative care in which the spiritual aspect is an important component together with the physical, psychological, and social. This article is based on a mixed methods study of spirituality among persons receiving palliative care. Findings revealed the importance of spirituality and its multidimensional elements by which spirituality was perceived as a complex phenomenon relating to religious and non-religious aspects of human life. Theological reflection based on the present findings indicates that a sharp distinction between the concepts of religion and spirituality is not beneficial. It also reveals the significance of the spiritual dimension and that theology has an important role in creating a deeper understanding of this complex part of human existence. Spiritual needs, expressed in various ways, were evident among the participants receiving palliative care. The findings confirm that the theological approach in palliative care, with its focus on the whole human being and emphasis on spirituality and the spiritual dimension, continues to be the hallmark of practicing theology within palliative care.     

Concurrent validity of the Personality Assessment Inventory Alcohol Problems (ALC) Scale in a college student sample

The concurrent validity of the Alcohol Problems scale (ALC) was investigated in a college student sample (N = 200). The relationships between the ALC and associated features of alcohol problems (e.g., consumption patterns, expectancies, maladaptive coping, and stress) were examined. The validity of the ALC for identifying clinically significant alcohol problems (assessed with the Structured Clinical Interview for the fourth edition ofthe Diagnostic and Statistical Manual of Mental Disorders) was also examined. The ALC was related to the associated features and was a valid indicator of alcohol problems. T scores of 80, 85, and 90 had superior hit rates for alcohol abuse; and scores of 80, 85, and 90 had superior hit rates for alcohol dependence.     

Moving Beyond Self‐Report: Implicit Associations about Death/Life Prospectively Predict Suicidal Behavior among Veterans

Reliance on self‐report limits clinicians' ability to accurately predict suicidal behavior. In this study the predictive validity of an objective measure, the death/suicide Implicit Association Test (d/sIAT), was tested among psychiatrically hospitalized veterans. Following acute stabilization, 176 participants completed the d/sIAT and traditional suicide risk assessments. Participants had similar d/sIAT scores regardless of whether they had recently attempted suicide. However, d/sIAT scores significantly predicted suicide attempts during the 6‐month follow‐up above and beyond other known risk factors for suicidal behavior (OR = 1.89; 95% CI: 1.15–3.12; based on 1SD increase). The d/sIAT may augment the accuracy of suicide risk assessment.     

Residual effects of emotion are reflected in enhanced visual activity after sleep

Research has investigated how sleep affects emotional memory and how emotion enhances visual processing, but these questions are typically asked by re-presenting an emotional stimulus at retrieval. For the first time, we investigate whether sleep affects neural activity during retrieval when the memory cue is a neutral context that was previously presented with either emotional or nonemotional content during encoding. Participants encoded scenes composed of a negative or neutral object on a neutral background either in the morning (preceding 12 hours awake; wake group) or evening (preceding 12 hours including a night of sleep; sleep group). At retrieval, participants viewed the backgrounds without their objects, distinguishing new backgrounds from those previously studied. Occipital activity was greater within the sleep group than the wake group specifically during the successful retrieval of neutral backgrounds that had been studied with negative (but not neutral) objects. Moreover, there was enhanced connectivity between the middle occipital gyrus and hippocampus following sleep. Within the sleep group, the percentage of REM sleep obtained correlated with activity in the middle occipital gyrus, lingual gyrus, and cuneus during the successful retrieval of neutral backgrounds previously paired with negative objects. These results confirm that emotion affects neural activity during retrieval even when the cues themselves are neutral, and demonstrate, for the first time, that this residual effect of emotion on visual activity is greater after sleep and may be maximized by REM sleep.