The Views of Pakistani Doctors Regarding Genetic Counseling Services – Is there a Future?

Pakistan is a densely populated country in South Asia with a high burden of genetic disease. A dearth of medical genetic services exists and master’s level trained genetic counselors (GCs) are currently not a part of the healthcare system. This study is the first to determine the views of Pakistani medical doctors (MDs) towards genetic counseling services in Pakistan, including what manner a master’s level genetic counselor might be incorporated into the healthcare system. Fifty-one MDs practicing in the city of Karachi completed a self-administered survey of twenty questions. Of the 49 respondents who answered a specific question, 100 % (49/49) felt that they would refer at least some, if not all, of their relevant patients to a genetic’s clinic if one existed in Karachi. Overall, the respondents showed a positive attitude towards the provision of genetic counseling services as a part of the healthcare system of Pakistan. Some of the proposed roles identified specifically for GCs included: explaining how Down syndrome occurs (66.1 %), discussing genes associated with breast cancer (77.4 %), and explaining the inheritance pattern of β-thalassemia (65.5 %). In contrast, the review of medical and family history and discussion of medical procedures such as ultrasound and amniocentesis were typically seen as the role of a physician. A majority of the respondents (98 %) were in favor of premarital carrier screening for thalassemia and would refer patients to a GC to describe the importance of carrier screening (84.3 %) and to help explain carrier screening results (94.1 %). Many respondents selected GCs as the ideal provider of education and support for people with inherited conditions (43.8 %), followed by specialist MDs (26 %) and general physicians (22.9 %). Considering the high burden of genetic disease in the country, we encourage the development of genetic counseling services in Pakistan.     

Parental Depression and Economic Disadvantage: The Role of Parenting in Associations with Internalizing and Externalizing Symptoms in Children and Adolescents

This study examined the effects of parental depression symptoms, economic disadvantage, and parenting behaviors in 180 children and adolescents of depressed parents (ages 9–15 years-old). Analyses revealed that while parental depression symptoms, economic disadvantage, and disrupted parenting behaviors were related to children’s internalizing and externalizing symptoms, disrupted parenting (e.g., intrusive, neglectful parenting) accounted for the association of parental depressive symptoms and economic disadvantage with children’s symptoms. This study provides evidence that disrupted parenting may be a common or shared process through which both parental depression and economic disadvantage are associated with children’s internalizing and externalizing problems.     

Verbal Sexual Coercion Experiences,Sexual Risk,and Substance Use in Women

Research has linked sexual assault, substance use, and sexually transmitted infection (STI) risk in women. Sexual assault by means of verbal sexual coercion (VSC) is more common than sexual assault by means of physical tactics, but VSC is rarely assessed independently. In addition, past work has established global connections among substance use, sexual assault history, and STI risk; however, assessing substance use during sexual behavior is less common. This study examined the relations among VSC, STI risk behavior, and substance use and attitudes. We hypothesized that women with larger numbers of VSC experiences would report more frequent sexual risk behaviors and substance use and attitudes. Participants with larger numbers of VSC experiences reported larger numbers of anal sex partners, more frequent penile–vaginal sex and sexual activity after substance use, and stronger sex-related alcohol expectancies. These findings suggest that VSC is associated with higher levels of STI risk in women.     

Word-List-Learning Performance in Younger and Older Adults: Intra-Individual Performance Variability and False Memory

ABSTRACT

We investigated the word-list-learning performance of younger and older adults over 4 consecutive days at different times of day to study age-related differences in consistency of performance over time and the influence of circadian variation on performance. Eighteen younger (M age, 23.4 years) and 18 older (M age, 73.3 years) men and women participated. The start time of testing alternated between morning and early evening across the 4 days of testing. On each test day, participants learned a different list of 15 unrelated words over four learning trials. As expected, younger adults performed better than older adults on immediate recall, delayed recall, and recognition. Contrary to our expectations, time of day did not significantly influence recall or recognition performance in either the older or younger adults. Older adults did show a greater incidence of false memory (i.e., previously learned list intrusions in free recall and false alarms in recognition) than younger adults. Older adults also exhibited greater intra-individual performance variability on the measures of false memory across test days. This variability was not related to circadian variation. False memory and variability of performance have both been linked to frontal systems dysfunction. The findings presented here are consistent with the notion that changes in cognition with aging in part reflect age-related decline in frontal lobe function.     

Attentional biases and memory for emotional stimuli in men and male rhesus monkeys

We examined attentional biases for social and non-social emotional stimuli in young adult men and compared the results to those of male rhesus monkeys (Macaca mulatta) previously tested in a similar dot-probe task (King et al. in Psychoneuroendocrinology 37(3):396–409, 2012). Recognition memory for these stimuli was also analyzed in each species, using a recognition memory task in humans and a delayed non-matching-to-sample task in monkeys. We found that both humans and monkeys displayed a similar pattern of attentional biases toward threatening facial expressions of conspecifics. The bias was significant in monkeys and of marginal significance in humans. In addition, humans, but not monkeys, exhibited an attentional bias away from negative non-social images. Attentional biases for social and non-social threat differed significantly, with both species showing a pattern of vigilance toward negative social images and avoidance of negative non-social images. Positive stimuli did not elicit significant attentional biases for either species. In humans, emotional content facilitated the recognition of non-social images, but no effect of emotion was found for the recognition of social images. Recognition accuracy was not affected by emotion in monkeys, but response times were faster for negative relative to positive images. Altogether, these results suggest shared mechanisms of social attention in humans and monkeys, with both species showing a pattern of selective attention toward threatening faces of conspecifics. These data are consistent with the view that selective vigilance to social threat is the result of evolutionary constraints. Yet, selective attention to threat was weaker in humans than in monkeys, suggesting that regulatory mechanisms enable non-anxious humans to reduce sensitivity to social threat in this paradigm, likely through enhanced prefrontal control and reduced amygdala activation. In addition, the findings emphasize important differences in attentional biases to social versus non-social threat in both species. Differences in the impact of emotional stimuli on recognition memory between monkeys and humans will require further study, as methodological differences in the recognition tasks may have affected the results.     

Reducing Implicit Prejudice

Implicit prejudices are social preferences that exist outside of conscious awareness or control. In this review, we summarize evidence for three mechanisms that influence the expression of implicit prejudice: associative change, contextual change, and change in control over implicit prejudice. We then review the evidence (or lack thereof) for answers to five open issues in implicit prejudice reduction research: (1) what shows effectiveness in real‐world application; (2) what doesn't work for implicit prejudice reduction; (3) what interventions produce long‐term changes in implicit prejudice; (4) measurement diversity in implicit prejudice reduction research; and (5) the relationship between implicit prejudice and behavior. Addressing these issues provides an agenda for clarifying the conditions and implications of reducing implicit prejudice.     

The Growth and Significance of Daily Variations in Infant Behavior

The authors asked 55 second-generation Chinese American adolescents (M age = 16.8 years) and 58 European American adolescents (M age = 17.0 years) to complete self-report measures of stress levels, use of coping strategies, psychological outcomes, and grades. Chinese American adolescents reported higher levels of everyday life event stress (e.g., stress from schoolwork), more depression, and higher grade point averages. Problem-focused and avoidance-coping behaviors moderated the effect of stress on negative adjustment for Chinese American youth but not for European American youth. Path analysis showed that avoidance coping behavior partially mediated the stress-to-negative adjustment relationship for Chinese American youth but not for European American youth. Stress was associated with lower grades in Chinese American youth, but the authors found no association for European American youth.     

Effects of Gradual Versus Sudden Training on the Cognitive Demand Required While Learning a Novel Locomotor Task

The cognitive demand required for a range of locomotor tasks has been described for a variety of populations. However, the effect of different training strategies on the cognitive demand required while learning novel locomotor tasks is not well understood and may inform physical rehabilitation. The authors examined whether two training strategies, gradual and sudden training, influenced the cognitive demand required while practicing a novel locomotor task, asymmetric split-belt treadmill walking. Simple reaction times and whole-body kinematics were recorded throughout practice. Gradual training resulted in significantly lower reaction times during much of training, suggesting that gradual training is less cognitively demanding than sudden training, possibly due to a reduction in error feedback or movement planning demands.     

Interventional Use of the Parent–Child Interaction Assessment–II Enactments: Modifying an Abused Mother's Attributions to Her Son

I. It was hypothesized that male Ss will project more on situations pertaining to the lives of men than on situations pertaining to the lives of women and that female Ss will project more on situations pertaining to the lives of women than on situations pertaining to the lives of men.

II. It was further hypothesized that male Ss and female Ss will not differ with regard to the amount of projection elicited by male and female pictorial figures. Transcendence Indices were used as measures of the amount of projection. Ss were 30 male college students and their wives. Hypothesis I was confirmed for men only. Hypothesis II was confirmed for men and for women.