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81.
Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
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Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation. This effect could not be blocked by antagonists of the mineralocorticoid receptor and glucocorticoid receptor (spironolactone and RU 38486, respectively). These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes. 相似文献
82.
Successful treatment of many childhood diseases once considered terminal has resulted in the emergence of long-term effects of the disease or consequences of treatment that were previously unrecognized. Many of these long-term effects involve the central nervous system (CNS) and are developmental in the way that they emerge over time. Because we are now able to observe the natural history of childhood diseases such as sickle cell anemia or HIV, or the consequences of treatment of disease such as leukemia, brain tumors, or kidney disease, we are also able to study a number of biological mechanisms that result in long-term neurocognitive impairment. While some of the neurodevelopmental outcomes can be directly linked to structural damage of the CNS, other systems (e.g., hematologic, immunologic, pulmonary) appear to play crucial indirect roles in the development of the CNS and neurocognitive abilities because of the way that they affect the course of brain development and activity of the brain across time. Important interactions between acute disease factors, biological mechanisms, age at the time of disease or treatment effect, and disruptions in patterns of development after successful treatment or management all provide support for a neurodevelopmental model of childhood chronic illness. Testing this model may make it possible to more accurately predict the timing and degree of severity of long-term neurodevelopmental consequences, provide guidance for improved treatment and prevention, and offer better understanding of neurodevelopmental disruptions that occur in other non-chronic illness related disabilities. 相似文献
83.
Natural scenes contain far more information than can be processed simultaneously. Thus, our visually guided behavior depends crucially on the capacity to attend to relevant stimuli. Past studies have provided compelling evidence of functional overlap of the neural mechanisms that control spatial attention and saccadic eye movements. Recent neurophysiological work demonstrates that the neural circuits involved in the preparation of saccades also play a causal role in directing covert spatial attention. At the same time, other studies have identified separable neural populations that contribute uniquely to visual and oculomotor selection. Taken together, all of the recent work suggests how visual and oculomotor signals are integrated to simultaneously select the visual attributes of targets and the saccades needed to fixate them. 相似文献
84.
520 college students from a public university in the southwest were questioned to examine correlations between having a tattoo and the presence of tattoos among their family and friends. Tattoos among both friends and family were positively correlated with respondents' having a tattoo. The magnitude of friends' influence was about double the influence of family. 相似文献
85.
What information is used for sorting pictures of complex stimuli into categories? We applied a reverse correlation method to reveal the visual features mediating categorization in humans and baboons. Two baboons and 6 humans were trained to sort, by species, pictures of human and baboon faces on which random visual noise was superimposed. On ambiguous probe trials, a human-baboon morph was presented, eliciting "human" responses on some trials and "baboon" responses on others. The difference between the noise patterns that induced the two responses made explicit the information mediating the classification. Unlike the humans, the baboons based their categorization on information that closely matched that used by a theoretical observer responding solely on the basis of the pixel similarities between the probe and training images. We show that the classification-image technique and principal components analysis provide a method to make explicit the differences in the information mediating categorization in humans and animals. 相似文献
86.
87.
Dialectical Behavior Therapy for Binge Eating Disorder (DBT-BED) aims to reduce binge eating by improving adaptive emotion-regulation skills. Preliminary findings have been promising but have only compared DBT-BED to a wait-list. To control for the hypothesized specific effects of DBT-BED, the present study compared DBT-BED to an active comparison group therapy (ACGT). Men and women (n = 101) meeting DSM-IV BED research criteria were randomly assigned to 20 group sessions of DBT-BED (n = 50) or ACGT (n = 51). DBT-BED had a significantly lower dropout rate (4%) than ACGT (33.3%). Linear Mixed Models revealed that posttreatment binge abstinence and reductions in binge frequency were achieved more quickly for DBT-BED than for ACGT (posttreatment abstinence rate = 64% for DBT-BED vs. 36% for ACGT) though differences did not persist over the 3-, 6-, and 12-month follow-up assessments (e.g., 12-month follow-up abstinence rate = 64% for DBT-BED vs. 56% for ACGT). Secondary outcome measures revealed no sustained impact on emotion regulation. Although both DBT-BED and ACGT reduced binge eating, DBT-BED showed significantly fewer dropouts and greater initial efficacy (e.g., at posttreatment) than ACGT. The lack of differential findings over follow-up suggests that the hypothesized specific effects of DBT-BED do not show long-term impact beyond those attributable to nonspecific common therapeutic factors. 相似文献
88.
Jordan P. LaBouff Wade C. Rowatt Megan K. Johnson Michelle Thedford Jo‐Ann Tsang 《Journal for the scientific study of religion》2010,49(3):439-455
An implicit measure of religiousness‐spirituality (RS) was constructed and used in two studies. In Study 1, undergraduates completed a Religiousness‐Spirituality Implicit Association Test (RS‐IAT) and several self‐report measures of RS and related constructs (e.g., religious fundamentalism, authoritarianism). Informants rated the participants’ RS. The RS‐IAT was internally consistent. Implicit RS correlated positively with self‐reported RS, spiritual transcendence, spiritual experiences, religious fundamentalism, and intrinsic religiousness. Informant ratings correlated positively with participants’ self‐reported religiousness but not implicit RS. In Study 2, implicit RS accounted for unique variability in self‐reported attitudes toward gay men and lesbian women when controlling for self‐reported religiousness and right‐wing authoritarianism. These findings demonstrate that an implicit measure of trait RS explains some variability in attitudes that self‐report measures do not. An implicit measure of RS could advance the scientific study of religion beyond what is known from self‐report measures. 相似文献
89.
Swami V Furnham A Chamorro-Premuzic T Akbar K Gordon N Harris T Finch J Tovée MJ 《The Journal of social psychology》2010,150(6):628-647
This study examined the influence of personality information on perceptions of the physical attractiveness of a range of female body sizes. A sample of 2,157 male university students were randomly assigned to one of 10 groups in which they received personality information about women they were rating, or a control group in which they received no personality information. Controlling for participants' age and body mass index, results showed no significant between-group differences in the body size that participants found most attractive. However, participants provided with positive personality information perceived a wider range of body sizes as physically attractive compared with the control group, whereas participants provided with negative personality information perceived a narrower range of body sizes as attractive. Correlations showed that participants' own Extraversion was associated with their body size ratings. These results suggest that non-physical cues have an influence on the perception of physical beauty. 相似文献
90.
ABSTRACT. Predicting behavior has been a main challenge in human movement science. An important step within the theory of coordination dynamics is to find out the rules that govern human behavior by defining order parameters and control parameters that support mathematical models to predict the behavior of a system. Models to describe human coordination have been focused on interlimb coordination and on interpersonal coordination in affiliative tasks but not on competitive tasks. This article aims to present a formal model with two attractors to describe the interactive behavior on a 2v1 system in rugby union. Interpersonal distance and relative velocity critical values were empirically identified and were included as task constraints that define the attractor landscape. It is shown that using relative velocity as a control parameter the model offers reasonable prediction concerning the decision-making process. The model has the plasticity to adapt to other settings where interpersonal distances and relative velocities amongst system components act as significant task constraints. 相似文献