Interactions between the dorsal and the ventral pathways in mental rotation: An fMRI study

In this fMRI study, we examined the relationship between activations in the inferotemporal region (ventral pathway) and the parietal region (dorsal pathway), as well as in the prefrontal cortex (associated with working memory), in a modified mental rotation task. We manipulated figural complexity (simple vs. complex) to affect the figure recognition process (associated with the ventral pathway) and the amount of rotation (0° vs. 90°), typically associated with the dorsal pathway. The pattern of activation not only showed that both streams are affected by both manipulations, but also showed an overadditive interaction. The effect of figural complexity was greater for 90° rotation than for 0° in multiple regions, including the ventral, dorsal, and prefrontal regions. In addition, functional connectivity analyses on the correlations across the time courses of activation between regions of interest showed increased synchronization among multiple brain areas as task demand increased. The results indicate that both the dorsal and the ventral pathways show interactive effects of object and spatial processing, and they suggest that multiple regions interact to perform mental rotation.     

Patterns of personality pathology in patients with generalized anxiety disorder, panic disorder with and without agoraphobia, and social phobia

The relationship between co-occurring personality disorders and anxiety disorders (panic disorder with or without agoraphobia, social phobia, and generalized anxiety disorder) was examined, taking into account the effect of major depression. This article describes findings for 622 participants in the Harvard/Brown Anxiety Research Project, a longitudinal follow-up study of DSM-III-R-defined anxiety disorders. A total of 24% of participants had at least one personality disorder, with avoidant, obsessive compulsive, dependent, and borderline most common. Generalized anxiety disorder, social phobia, and major depression were positively associated with the occurrence of one or more personality disorders, whereas panic disorder with agoraphobia was not associated. Major depression was associated in particular with dependent, borderline, histrionic, and obsessive compulsive personality disorders and social phobia was associated with avoidant personality disorder. Whereas some of our findings confirm results from earlier studies, others are somewhat inconsistent with previous results and indicate the need for further investigation.     

Marriage and family therapy education: Emerging trends and issues

The field of marriage and family therapy has enjoyed unparalleled growth during the last decade. This rapid growth has been the catalyst for several emerging educational trends that warrant close attention. This paper examines nine emerging trends in MFT education with attention devoted to a number of critical issues.     

The study of reciprocal influences through experimental modification of social interaction between functional adult-child pairs

Studies using the Functional Pairs Approach to the study of socialization processes are reviewed, and its strengths and weaknesses are discussed. By staging social encounters between children and biologically unrelated adults, this approach can achieve excellent isolation of causal effects involving a wide range of behaviors. Its main limitation concerns the extent to which the results obtained from staged interactions between unfamiliar children and adults generalize to real parent-child relations. Through careful construction of experimental situations, this limitation can be partially overcome. Ultimately, the choice of a method will depend on several considerations, including the complexity of the behavior to be manipulated and the relative importance of generalizability versus clear isolation of effects. The decisions involved in investigating causal influences between parents and children are summarized in a flow chart.     

Self-motion sensation influenced by visual fixation

Subjects were exposed to angular decelerations of between 1 and 50 deg/sec’ (1) in total darkness, (2) in view of a dim subject-stationary fixation light, or (3) inside an illuminated subject-stationary striped cylinder (conflict stimulation). Vestibularly induced eye movements led to the oculogyral illusion of object motion. This phenomenon can be distinguished from that of the sensation of self-rotation. At the end of deceleration, the initial velocity of self-rotation sensation is similar during all three stimulus conditions, but is reduced in duration with the conflict stimulus. Differences of interpretation in the literature concerning these phenomena can be explained on the basis of the failure to distinguish between the oculogyral illusion and sensation of self-motion and the inability to fully suppress vestibular eye movements.     

Neuropsychological differentiation of depression and anxiety

The high comorbidity of depression and anxiety is well established empirically but not well understood conceptually, in terms of either psychological or biological mechanisms. A neuropsychological model of regional brain activity in emotion provides contrasting hypotheses for depression and anxiety, with depression associated with a relative decrease and anxiety with a relative increase in right-posterior activity. These hypotheses received support in a comparison of individuals diagnosed with depression and community controls, and also in a separate study of nonpatients administered a measure of perceptual asymmetry. Hierarchical regressions revealed that depression and anxiety were uniquely and jointly associated with perceptual asymmetry. In light of consistent empirical support for the model, implications for conceptualizations of the comorbidity of depression and anxiety are discussed.     

Genetic Knowledge Among Participants in the Coriell Personalized Medicine Collaborative

Genetic literacy is essential for the effective integration of genomic information into healthcare; yet few recent studies have been conducted to assess the current state of this knowledge base. Participants in the Coriell Personalized Medicine Collaborative (CPMC), a prospective study assessing the impact of personalized genetic risk reports for complex diseases and drug response on behavior and health outcomes, completed genetic knowledge questionnaires and other surveys through an online portal. To assess the association between genetic knowledge and genetic education background, multivariate linear regression was performed. 4 062 participants completed a genetic knowledge and genetic education background questionnaire. Most were older (mean age: 50), Caucasian (90 %), female (59 %), highly educated (69 % bachelor’s or higher), with annual household income over $100 000 (49 %). Mean percent correct was 76 %. Controlling for demographics revealed that health care providers, participants previously exposed to genetics, and participants with ‘better than most’ self-rated knowledge were significantly more likely to have a higher knowledge score (p?<?0.001). Overall, genetic knowledge was high with previous genetic education experience predictive of higher genetic knowledge score. Education is likely to improve genetic literacy, an important component to expanded use of genomics in personalized medicine.