Topiramate in the preventive treatment of episodic migraine: a combined analysis from pilot,double-blind,placebo-controlled trials

The safety and efficacy of medications for preventive treatment of migraine is the subject of current concern and investigation in health care. Two single-center, double-blind, placebo-controlled studies were conducted to evaluate the efficacy and safety of topiramate for migraine prophylaxis. Seventy patients with a diagnosis of migraine were randomly assigned to topiramate-treated and placebo groups. The studies consisted of a 4-week baseline phase, a 6-8 week titration, and 8-12 weeks of maintenance. Topiramate was titrated from an initial dose of 25 mg/day to a target dose of 100 mg BID. The primary efficacy measure, the mean 28-day migraine frequency, was lower in topiramate-treated patients than in the placebo group (3.2 versus 3.8, P=.001). Similarly, topiramate treatment resulted in a significantly greater mean reduction in migraine frequency than did placebo (1.55 versus 0.47, P=.001) and a significantly higher responder rate (35.3% versus 8.3%, P=.008). Paresthesia was the most common side effect reported with topiramate treatment. Other topiramate-associated adverse events included altered taste, memory impairment, diarrhea, and appetite suppression/weight loss. The rates of discontinuation were similar for the topiramate group (n=10) and the placebo group (n=8). These results suggest that topiramate is effective and well tolerated in the preventive treatment of migraine headaches.     

Computerizing reading training: Evaluation of a latent semantic analysis space for science text

The effectiveness of a domain-specific latent semantic analysis (LSA) in assessing reading strategies was examined. Students were given self-explanation reading training (SERT) and asked to think aloud after each sentence in a science text. Novice and expert human raters and two LSA spaces (general reading, science) rated the similarity of each think-aloud protocol to benchmarks representing three different reading strategies (minimal, local, and global). The science LSA space correlated highly with human judgments, and more highly than did the general reading space. Also, cosines from the science LSA spaces can distinguish between different levels of semantic similarity, but may have trouble in distinguishing local processing protocols. Thus, a domain-specific LSA space is advantageous regardless of the size of the space. The results are discussedin the context of applying the science LSA to a computer-based version of SERT that gives online feedback based on LSA cosines.     

Concurrent validity of the Peabody Picture Vocabulary Test-Third Edition as an intelligence and achievement screener for low SES African American children

Authors tested the validity of the Peabody Picture Vocabulary Test-Third Edition (PPVT-III) as a screening measure for intelligence and achievement. The PPVT-III and Kaufman Assessment Battery for Children (KABC) were administered to 416 African American children of low socioeconomic status in a counterbalanced design. Results indicated that the PPVT-III correlated .58 with the KABC Mental Processing Composite (MPC) score; however, participants scored significantly lower (M = 8.3 points) on the PPVT-III than on the MPC. Although receiver operating characteristic (ROC) analyses supported the use of the PPVT-III as a valid intellectual and achievement screener, the selection of a single cutoff score for the PPVT-III was problematic. The purpose of the screening program should guide selection of a cutoff score for the PPVT-III.     

Coincidence timing of finger, arm, and whole body movements

Two experiments investigated the effects of different types of movement responses on coincidence timing skill. The view was taken that the sensory-motor integration of the movement responses would be reflected in the accuracy and consistency of anticipation timing. A Bassin anticipation timer provided a light stimulus velocity of 3 mph for both experiments and the movements studied included a simple key press using a finger, an arm movement to a key press, and whole body movements culminating with a kick or step to a target. The experiments were modelled closely on the seminal study by Grose (1967). The results of Exp. 1 supported our prediction by demonstrating superiority of the finger task over the two larger movements for all measures of coincidence timing ability. The purpose of Exp. 2 was to compare the slightly different versions of the whole body task-that used in the first experiment and that used by Grose (1967). The results confirmed the close similarity of the two movement tasks and re-affirmed the results of Exp. 1. Exp. 2 also investigated sex effects on coincidence timing ability and, in contrast to previous evidence indicating that females perform with less accuracy and consistency than do males, no significant differences were found. Analysis of practice effects showed that, although there were no significant improvements over trial blocks in Exp. 1, there were significant improvements in Exp. 2. Comparisons with other research suggests that repeated practice in solving a coincident timing problem using whole body movements can lead to improved performance. In general, the findings are consistent with the constructs of action theory and emphasize the roles perceptual and movement variables have in defining situational constraints. Also, findings indicate that proficiency in coincidence anticipation appears to be influenced by the planning and organisation required for movement execution.     

The use of diagrams in analogical problem solving

In four experiments, we examined the impact of perceptual properties on the effectiveness of diagrams in analogical problem solving, using variants of convergence diagrams as source analogues for the radiation problem. Static diagrams representing the initial problematic state (one large line directed at a target) and the final state for a convergence solution (multiple converging lines) were not accessed spontaneously but were often used successfully once a hint to consider the diagram had been provided. The inaccessibility of static diagrams was not alleviated by adding additional diagrams to represent intermediate states (Experiment 1), but spontaneous access was improved by augmenting static diagrams with a verbal statement of the convergence principle (Experiment 3). Spontaneous retrieval and noticing were increased markedly by animating displays representing converging forces and thereby encouraging encoding of the lines as indicating motion toward a target (Experiments 3 and 4). However, neither static nor animated diagrams were effective when the arrows were reversed to imply divergence rather than convergence (Experiment 2). The results indicate that when animation encourages the interpretation of a diagram as a helpful source analogue, it can greatly enhance analogical transfer.     

Global context effects on processing lexically ambiguous words: Evidence from eye fixations

Readers' eye movements were monitored as they read biased ambiguous target words in the context of a short paragraph. Two aspects of context were manipulated. The global context was presented in the topic sentence of the paragraph and instantiated either the dominant or the subordinate meaning of biased ambiguous target words (those with highly dominant meanings). Local contextual information either preceded or followed the target word and was always consistent with the subordinate interpretation. Consistent with prior research, we obtained a subordinate bias effect wherein readers looked longer at the ambiguous words than control words when the preceding context instantiated the subordinate meaning. More importantly, the magnitude of the subordinate bias effect was the same when global context alone, local context alone, or local and global context combined were consistent with the subordinate meaning of the ambiguous word. The results of this study indicate that global contextual information (1) has an immediate impact on lexical ambiguity resolution when no local disambiguating information is available, (2) has no additional effect when it is consistent with local information, but (3) does have a slightly delayed effect when inconsistent with local information.     

The importance of monitoring and self-regulation during multitrial learning

Theory suggests that accuracy of metacognitive monitoring and self-regulation of study will affect test performance, but there is little empirical evidence linking these variables. I examined the relation among these variables in a multitrial learning task. Regression analyses showed that monitoring accuracy and self-regulation were reliably related to test performance--greater monitoring accuracy and more effective self-regulation were associated with greater test performance. These analyses were contrasted with analyses typically conducted in previous research, to show the importance of using a multitrial learning task and of attending to the theoretically based causal relation among variables when evaluating how monitoring accuracy and self-regulation are related to test performance. The results of this investigation may help to explain why previous research has failed to link these variables.     

Does contextual strength modulate the subordinate bias effect? A reply to Kellas and Vu

In their reply to Binder and Rayner (1998), Kellas and Vu (1999) raised questions about the criteria we used to exclude items from the Kellas, Martin, Yehling, Herman, and Vu (1995) stimulus set. In this reply, we further document these criteria and also address the issue of local versus published norms. We continue to believe that the stimulus set used by Kellas et al. (1995) was problematic. We also address the issue of strength of context, a concept used in earlier research that dealt with the subordinate bias effect. We argue that the contexts used by Kellas et al. (1995) were no stronger than the contexts previously used that established this effect. Therefore, we continue to think that our finding that context does not eliminate the subordinate bias effect is valid.     

A Comparative Study of Educational and Cultural Determinants of Adolescent Values

This article compares the results of three surveys in adolescent values. The subjects comprise young people with a modal age of 15 years from three countries‐‐England, Saudi Arabia and the United States. The contrasting educational systems of these countries are described with particular reference to the place of religious education within their curricula. An open‐ended questionnaire, designed to prompt statements from young people about their values, is introduced and its provenance is described. Similarities but also significant differences are found in the values expressed across the three cultures. Most marked is the high value placed on parents and friendship by the English young people, the importance attached to being well adjusted and feeling good about oneself in the American group and the prominence given to Islam by the Saudi Arabian adolescents.