肿瘤疫苗治疗肿瘤的前景

肿瘤疫苗的发展已经历了一个多世纪,20世纪50年代,人们开始了自体肿瘤疫苗的研究.使肿瘤疫苗(主动性免疫治疗)成为继手术、放疗、化疗之后的肿瘤治疗方法.肿瘤疫苗作为主动特异性免疫治疗,在临床中起到越来越重要的作用,人们开始尝试利用多种方法制备肿瘤疫苗并利用其促进机体免疫应答,从整体细胞,分子水平调控机体对肿瘤的免疫.目前肿瘤疫苗的研制已取得很大进展,给人类战胜肿瘤提供很大希望。     

小学生快速阅读的眼动研究

用自然实验和实验室实验考察了对小学四年级学生进行快速阅读训练的有效性,结果发现：（1）快速阅读训练可以显著地提高小学生的有效读速;（2）快速阅读训练可以显著减少注视次数、注视点平均持续时间;（3）快速阅读训练可以显著扩大眼跳距离。     

关于学习环模式的研究综述

学习环模式是一种有效的科学学习与教学模式。西方科学教育工作者对此做了大量研究,取得了丰硕成果。本文综述了学习环模式的理论基础、基本结构与发展。这一模式对于我国当前中小学科学课程设计和探究性学习的开展有一定的借鉴意义。     

家校合作研究述评

近30年来．国内外研究者在家校合作的研究和实践上取得了一些卓有成效的研究成果。本文从家校合作分类、家校合作模式及实践、家校合作的理论基础三个方面介绍了家校合作研究的进展,并分析了我国家校合作研究存在的问题以及未来的研究走向。     

事件性前瞻记忆的加工机制：来自ERP的证据

采用事件相关电位技术,对前瞻记忆的加工机制——主要是执行前的加工机制进行研究。控制条件为单纯的背景任务,实验条件为背景任务含前瞻记忆任务,对两种条件下非靶线索的行为数据进行比较,结果表明实验条件下被试的反应时显著长于控制条件,可能说明两种条件的认知过程存在差异,这种差异在ERPs上主要体现为刺激呈现200ms以后,两种条件的波形和脑地形图存在显著差异。结果支持预备注意加工和记忆加工理论,也部分支持多重加工理论     

Latent variable models for analyzing children's processing ability

In this paper, we develop a latent processing ability model to analyze the speed of processing ability data. Our approach can not only effectively evaluate the effects of covariates on the latent processing ability, but also estimate the latent trait of each child by calculating its posterior mean. In addition, we derive the correlations structure of latent traits among different age groups. Simulations are conducted to evaluate the performance of our proposed model. The results indicated that the estimation of model parameters is satisfactory overall. The method is evaluated using real data from children aged 4–7 years in Changchun, China.     

Moderation Analysis Using a Two-Level Regression Model

Moderation analysis is widely used in social and behavioral research. The most commonly used model for moderation analysis is moderated multiple regression (MMR) in which the explanatory variables of the regression model include product terms, and the model is typically estimated by least squares (LS). This paper argues for a two-level regression model in which the regression coefficients of a criterion variable on predictors are further regressed on moderator variables. An algorithm for estimating the parameters of the two-level model by normal-distribution-based maximum likelihood (NML) is developed. Formulas for the standard errors (SEs) of the parameter estimates are provided and studied. Results indicate that, when heteroscedasticity exists, NML with the two-level model gives more efficient and more accurate parameter estimates than the LS analysis of the MMR model. When error variances are homoscedastic, NML with the two-level model leads to essentially the same results as LS with the MMR model. Most importantly, the two-level regression model permits estimating the percentage of variance of each regression coefficient that is due to moderator variables. When applied to data from General Social Surveys 1991, NML with the two-level model identified a significant moderation effect of race on the regression of job prestige on years of education while LS with the MMR model did not. An R package is also developed and documented to facilitate the application of the two-level model.     

Development and validation of a Christian-based Grief Recovery Scale

The purpose of this study was to develop and validate a Christian-based Grief Recovery Scale (CGRS) which was used to measure Christians recovering from grief after a significant loss. Taiwanese Christian participants were recruited from churches and a comprehensive university in northern Taiwan. They were affected by both the Christian faith and Chinese cultural beliefs. The CGRS is developed through replicated factor analyses in three stages. The final version of the CGRS retains 35 Likert-type items and consists of six factors: spiritual well-being; recovering meaning and sense of control; ongoing physical and emotional responses; reassuring faith; strongly missing a deceased loved one; and life disturbance. The evidence for CGRS reliability and validity is highlighted. Implications for research and counselling practice are suggested.     

Effects of Three Sources of Social Support on Survivors' Posttraumatic Stress After the Wenchuan Earthquake

This study investigated the relationship between social support and symptoms of posttraumatic stress among adolescents who were exposed to the 2008 Wenchuan earthquake in China. The results showed that three sources of social support—support from family, support from friends, and support from significant others—have significant main effects on posttraumatic stress disorder (PTSD). Buffering effects of social support were not supported. Gender and residency were also associated with PTSD, with female adolescents and adolescents from rural areas demonstrating higher levels of PTSD than their male counterparts and adolescents from urban and township areas.