PTSD易感性人格特质、工作记忆能力和创伤期间认知加工对模拟创伤闪回的影响

基于模拟创伤研究范式, 采用道路交通事故影片对159名健康大学生进行模拟创伤, 考察PTSD易感性人格特质(特质焦虑、特质分离和神经质)、工作记忆能力(注意控制和工作记忆容量)和创伤期间认知加工(数据驱动加工和概念加工)对模拟创伤后不同时段闪回的影响。运用结构方程模型分析数据, 结果发现：(1)数据驱动加工正向预测不同时段闪回(即时闪回、一周闪回和触发闪回)的数量、生动性、痛苦度以及一周侵入频率; (2)神经质正向预测触发闪回痛苦度, 注意控制和工作记忆容量负向预测一周侵入频率; (3)概念加工在注意控制与即时闪回痛苦度之间起中介作用。研究结果提示：数据驱动加工是创伤后不同时段闪回的主要影响因素; 概念加工主要作用于早期急性应激反应, 注意控制是其保护因素; 神经质和工作记忆能力对闪回具有较长期的影响, 且工作记忆能力具有一定的保护作用。     

Psychiatric Distress and Suicidal Tendencies in Adult Cancer Survivors: Verifying the Validity of the Brief Symptom Inventory-18 for Identifying Suicidal Ideation in the Hospitalized Population of Mainland China

The Brief Symptom Inventory-18 (BSI-18) is widely used to assess psychiatric distress but has not been verified in the Chinese population. From March to April 2019, 293 hospitalized cancer patients, aged 20–87, completed the cross-sectional survey with demographics questionnaire, BSI-18, and PHQ-9. We analyzed the single suicide-related item of PHQ-9 with the full score clinical outpoint for BSI-18 and PHQ-9 using SPSS 22.0 and R 2.15, including Pearson's χ² test and ROC curve analyses. A Pearson's χ² test was carried out to compare the three different methods with the gold screening criteria. The p-value was correspondingly to .006, .066, .838. When the PHQ-9?≥?10 criteria for the BSI-18, receiver operating characteristic analysis revealed that AUC values were 0.839, optimal cut-off points for both BSI-18?≥?50, the sensitivity of 85.8%, and 62.5%, respectively. The BSI-18 is suitable for a screening tool for psychological distress and could also be used in clinical settings for preliminary screening of hospitalized cancer patients.

     

Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling

Xamoterol, a partial β(1)-adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats. In contrast, xamoterol restores memory retrieval in gene-targeted mice lacking norepinephrine (NE) and in a transgenic mouse model of Down syndrome in which NE levels are reduced. Restoration of retrieval by xamoterol in these two models complements the observation that NE and β(1) signaling are required for hippocampus-dependent retrieval of contextual and spatial reference memory in wild-type mice and rats. Additional evidence indicates that cAMP-mediated PKA and Epac signaling are required for the retrieval of hippocampus-dependent memory. As a result, we hypothesized that xamoterol has effects in addition to the stimulation of β(1) receptors that, at higher doses, act to counter the effects of β(1) signaling. Here we report that xamoterol-induced disruption of memory retrieval depends on β(2)-adrenergic receptor signaling. Interestingly, the impairment of memory retrieval by xamoterol is blocked by pretreatment with pertussis toxin, an uncoupling agent for G(i/o) signaling, suggesting that β(2) signaling opposes β(1) signaling during memory retrieval at the level of G protein and cAMP signaling. Finally, similar to the time-dependent roles for NE, β(1), and cAMP signaling in hippocampus-dependent memory retrieval, xamoterol only impairs retrieval for several days after training, indicating that its effects are also limited by the age of the memory. We conclude that the disruption of memory retrieval by xamoterol is mediated by G(i/o)-coupled β(2) signaling, which opposes the G(s)-coupled β(1) signaling that is transiently required for hippocampus-dependent emotional memory retrieval.     

略论邹衍对鲁学与齐学的融通

鲁国与齐国由于地理环境、经济发展状况以及统治政策的不同,造成了鲁学与齐学在诸多方面存在差异。但是到了战国中后期,阴阳家邹衍对鲁学与齐学进行了兼采,形成了独具特色的阴阳五行学说。特别是其五德终始说,既对稷下的学术著作《黄帝四经》、《管子》有所借鉴,又对鲁学的主体儒学的仁义思想、经世致用理论有所吸收,进而使鲁学与齐学达到了初步的融通。     

A twin study of spatial and non-spatial delayed response performance in middle age

Delayed alternation and object alternation are classic spatial and non-spatial delayed response tasks. We tested 632 middle-aged male veteran twins on variants of these tasks in order to compare test difficulty, measure their inter-correlation, test order effects, and estimate heritabilities (proportion of observed variance due to genetic influences). Non-spatial alternation (NSA), which may involve greater reliance on processing of subgoals, was significantly more difficult than spatial alternation (SA). Despite their similarities, NSA and SA scores were uncorrelated. NSA performance was worse when administered second; there was no SA order effect. NSA scores were modestly heritable (h(2)=.25; 26); SA was not. There was shared genetic variance between NSA scores and general intellectual ability (r(g)=.55; .67), but this also suggests genetic influences specific to NSA. Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples.     

An attentional blink for nontargets?

In a typical attentional blink experiment, viewers try to detect two target items among distractors in a Rapid Serial Visual Presentation (RSVP): processing of the first target impairs participants' ability to recall a subsequent target at short stimulus onset asynchronies (SOAs). However, little is known about whether target detection interferes with memory for nontarget items. To answer this question, in two experiments, we employed a novel dual-task procedure: participants searched for a word target (e.g., "a four-footed animal") and then were tested for recognition of nontarget words. Detection of the target word, which was present on half the trials, produced a standard attentional blink effect on memory for nontarget words, with lag 1 sparing followed by an attentional blink at longer lags. This result shows that target processing has a generalized effect on processing of later events, not only other targets.     

Font size modulates saccade-target selection in Chinese reading

In alphabetic writing systems, saccade amplitude (a close correlate of reading speed) is independent of font size, presumably because an increase in the angular size of letters is compensated for by a decrease of visual acuity with eccentricity. We propose that this invariance may (also) be due to the presence of spaces between words, guiding the eyes across a large range of font sizes. Here, we test whether saccade amplitude is also invariant against manipulations of font size during reading Chinese, a character-based writing system without spaces as explicit word boundaries for saccade-target selection. In contrast to word-spaced alphabetic writing systems, saccade amplitude decreased significantly with increased font size, leading to an increase in the number of fixations at the beginning of words and in the number of refixations. These results are consistent with a model which assumes that word beginning (rather than word center) is the default saccade target if the length of the parafoveal word is not available.     

Emotion-cognition interaction in people at familial high risk for schizophrenia: the impact of sex differences

Cognitive deficits are fundamental to schizophrenia, and research suggests that negative emotion abnormally interferes with certain cognitive processes in those with the illness. To a lesser extent, cognitive impairment is found in persons at risk for schizophrenia, but there is limited research on the impact of emotion on cognitive processing in at-risk groups. It is unknown whether interference of negative emotion precedes illness and contributes to vulnerability for the disorder. We studied the extent to which negative emotional information interferes with working memory in 21 adolescent and young adult first-degree relatives of people with schizophrenia and 22 community controls. Groups were comparable in age, sex, education, ethnicity, and socioeconomic status. Primary measures were n-back tasks varying in cognitive load (1-back, 2-back, 3-back) with emotional faces (neutral, happy, fearful) as stimuli. The control group's response times (RTs) and the women's RTs, regardless of group, differed depending on the emotion condition. In contrast, the RTs of the relatives and of the men, regardless of group, did not differ by emotion. This study is the first to examine emotion-cognition interactions in relatives of individuals with schizophrenia. Reduced efficiency in processing emotional information may contribute to a greater vulnerability for schizophrenia that may be heightened in men. Additional research with larger samples of men and women is needed to test these preliminary findings.     

A Concise History of Chinese Psychology of Religion

The history of religious thought and the history of human thought are closely interrelated, so the study of Chinese psychology of religion should pay attention to the study of Chinese history. In this paper, we summarize the history of Han Chinese psychology of religion in three stages from the perspectives of the history of Chinese thought, the history of Chinese religion, and the history of Chinese psychology. In the accumulation stage during the Spring and Autumn and Warring States periods, debates about “human nature” were central to a psychology of religion. We hope that this will be helpful for the further study of Chinese psychology of religion.     

HBV相关肝细胞癌综合治疗中抗病毒的作用

分析抗病毒治疗在乙型肝炎病毒相关肝细胞癌的综合治疗中所起的作用.随着肝细胞癌治疗模式的转变,目前认为抗HBV治疗是HCC综合治疗的重要组成部分,应针对患者进行个体化、优化的多学科综合治疗,选择合适的高效、低耐药、低副作用的抗病毒药物,才能达到提高患者生活质量和延长生存时间的目的.