Differential effects of m1 and m2 receptor antagonists in perirhinal cortex on visual recognition memory in monkeys

Microinfusions of the nonselective muscarinic antagonist scopolamine into perirhinal cortex impairs performance on visual recognition tasks, indicating that muscarinic receptors in this region play a pivotal role in recognition memory. To assess the mnemonic effects of selective blockade in perirhinal cortex of muscarinic receptor subtypes, we locally infused either the m1-selective antagonist pirenzepine or the m2-selective antagonist methoctramine in animals performing one-trial visual recognition, and compared these scores with those following infusions of equivalent volumes of saline. Compared to these control infusions, injections of pirenzepine, but not of methoctramine, significantly impaired recognition accuracy. Further, similar doses of scopolamine and pirenzepine yielded similar deficits, suggesting that the deficits obtained earlier with scopolamine were due mainly, if not exclusively, to blockade of m1 receptors. The present findings indicate that m1 and m2 receptors have functionally dissociable roles, and that the formation of new visual memories is critically dependent on the cholinergic activation of m1 receptors located on perirhinal cells.     

Testing the effects of social anxiety disorder on friendship quality across gender and ethnicity

Previous research suggests that social anxiety disorder (SAD) has a specific relationship with impairment in friendship quality; however, potential moderators of this relationship have not been tested. The current study examines whether the specific effect of SAD on friendship quality is stable or varies across gender and ethnicity in a large epidemiological dataset. Results indicate that the underlying construct of friendship quality differed slightly but significantly between men and women; as a result, effects of SAD were tested in men and women separately. After partially constraining friendship quality across ethnic groups, our results indicated that the relationship between SAD and friendship quality remained robust in all groups. In addition to replicating the finding that SAD specifically relates to perceived friendship quality, the current study highlights the need to test whether underlying constructs such as friendship quality are consistent across the groups that make up heterogeneous samples.     

Derived Conditional Position Discrimination in Individuals without Naming Skills

The Psychological Record - Derived conditional discrimination was evaluated in 2 men with mental retardation whose language was limited to gestural requests. In each conditional-discrimination...     

Conditional discrimination in mentally retarded adults: the effect of training the component simple discriminations.

Two subjects with retardation who exhibited generalized identity matching, but who had extensive histories of failure to acquire arbitrary matching, were exposed to a series of conditions designed to train separately the components of a two-choice conditional discrimination. First, the successive discrimination between the sample stimuli was established by programming a different schedule of reinforcement in the presence of each sample stimulus. Schedule performance was acquired and maintained by both subjects, but neither acquired arbitrary matching. To train the simultaneous discrimination between the comparison stimuli, 1 subject was then exposed to a series of simple discrimination reversals and subsequently failed to acquire arbitrary matching. Both subjects acquired arbitrary matching under a procedure that maintained both the sample and the comparison discrimination by first presenting entire sessions composed of one sample-comparison relation and then gradually reducing the number of consecutive trials with the same sample until sample presentation was randomized (schedule performance was maintained). Removal of the schedule requirement had no effect on arbitrary matching accuracy. Both subjects subsequently demonstrated control by relations symmetric to the trained relations.     

Equivalence classes generated by sequence training

In Experiment 1, 3, adult females were taught with verbal instructions and contingencies to select, in sequence, three arbitrary visual stimuli from an array of five stimuli. After four different sequences were taught, match-to-sample tests assessed emergent conditional relations among all stimuli that had been selected in the same order in the sequences. Subjects' performances indicated development of four stimulus classes, three based on ordinal position and one based on nonselection. Next, match-to-sample training established conditional relations between each of four novel figures and one member of each of the ordinal stimulus classes. Tests confirmed that the classes were equivalence classes, each expanded by one new member. In subsequent sequence tests, the new stimuli were selected in a sequence that was consistent with ordinal class membership. Experiment 2 replicated Experiment 1 with 2 different adult females, but the verbal instructions were omitted. Results were similar to Experiment 1, except that extensive review and retesting were required before expansion of the ordinal classes with the novel figures was observed.     

Conditional discrimination in mentally retarded subjects: programming acquisition and learning set.

In Experiment 1, 3 subjects with retardation were exposed to two visual-visual arbitrary matching-to-sample problems each day. One conditional discrimination was presented under trial-and-error conditions, and the other was presented under a component training procedure. The latter began by establishing the comparison discrimination and its rapid reversal. The successive discrimination between the sample stimuli was established through differential naming. Then, sample naming was maintained in conditional discrimination sessions in which the same sample was presented in blocks of consecutive trials. Block size was decreased across sessions until sample presentation was randomized as in trial-and-error training (but with naming maintained). Two subjects initially learned only with component training. The performance of the 3rd subject was inconsistent across conditional discriminations. One of the successful subjects ultimately learned rapidly and consistently with trial-and-error procedures. Experiment 2 sought to demonstrate learning set in the other 2 subjects. Elements of the component training procedure were withdrawn over successive conditional discriminations. Ultimately, 1 subject nearly always learned under trial-and-error conditions, and the other learned under trial-and-error conditions combined with differential sample naming.     

The role of instructions in the transfer of ordinal functions through equivalence classes

In two experiments, adult subjects completed match-to-sample training and testing to establish four equivalence classes of four figures each. Then the subjects were taught one three-position sequence consisting of one stimulus from Class 1, one from Class 2, and one from Class 3. Inclusion of Class 4 stimuli in sequences was never reinforced, but two different stimuli from Class 4 appeared as distractors on each sequence trial. Tests assessed whether subjects would produce novel three-position sequences composed of members of Classes 1 through 3 that had not been used in sequence training. Three subjects in Experiment 1 received instructions about the match-to-sample and sequencing tasks, in addition to training contingencies. All 3 demonstrated equivalence class formation after match-to-sample training. After they were taught one sequence with one member of Classes 1 through 3, none of these subjects produced untrained sequences with other equivalence class members reliably. One additional sequence was trained directly; thereafter 1 subject showed some evidence of transfer of the trained ordinal functions across the remaining members of the equivalence classes, but the other 2 did not. Following a review of equivalence class training and testing and a review of the original sequence training, all 3 subjects produced most of the predicted, untrained sequences on tests. Experiment 2 replicated Experiment 1 with 2 adults but omitted all instructions except the minimal ones necessary to initiate responding. Unlike the subjects in Experiment 1, both of these subjects demonstrated virtually complete transfer of ordinal functions through the equivalence classes after direct training on just one sequence composed of one member of Classes 1 through 3.     

Attachment style, traumatic bonding, and developing relational capacities in a long-term trauma group for women.

Adults with histories of severe childhood abuse often experience considerable difficulties with interpersonal trust. At the same time, they may strongly desire to be less alone with the painful aftereffects of their traumatic pasts. Psychotherapy groups have often been recommended as important components of treatment for reducing survivors' feelings of isolation and shame. We propose that an understanding of attachment styles and of traumatic bonding helps to clarify the specific manifestations of interpersonal distrust as they may emerge in a survivors' group. In addition, we suggest guidelines for determining what kind of group may be appropriate for a given individual at a particular point in treatment.     

Tactile discrimination of competing sounds

Discriminably different sounds, concurrently presented from the left and right of the medial plane, were reduced in angular separation until subjects could no longer detect which sound was “left” and which was “right.” The procedure was repeated with hearing masked and judgments made on the basis of the tactile signals at two fingertip vibrators that received their inputs from two miniature microphones bilaterally located on the subject’s head. Auditory and tactile performance were compared under active (head movements permitted) and passive (head held still) conditions. Active and passive performance were not significantly different. Auditory and tactile performance became no better than chance at angular separations of 2.7° and 4.4°, respectively. Touch compared sufficiently well with audition to support arguments for the inclusion of sound localization information in devices which use the skin as a substitute for the ear. nt]mis|This research was conducted at the Smith-Kettlewell Institute of Visual Sciences, San Francisco, California. This institute provided the apparatus for the experiment. B. L. Richardson was on Staff Development Leave from the Applied Psychology Department of the Caulfield Institute of Technology, Melbourne, Australia.