Severity of dysfluency correlates with basal ganglia activity in persistent developmental stuttering

Previous studies suggest that anatomical anomalies [Foundas, A. L., Bollich, A. M., Corey, D. M., Hurley, M., & Heilman, K. M. (2001). Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering. Neurology, 57, 207-215; Foundas, A. L., Corey, D. M., Angeles, V., Bollich, A. M., Crabtree-Hartman, E., & Heilman, K. M. (2003). Atypical cerebral laterality in adults with persistent developmental stuttering. Neurology, 61, 1378-1385; Foundas, A. L., Bollich, A. M., Feldman, J., Corey, D. M., Hurley, M., & Lemen, L. C. et al., (2004). Aberrant auditory processing and atypical planum temporale in developmental stuttering. Neurology, 63, 1640-1646; Jancke, L., Hanggi, J., & Steinmetz, H. (2004). Morphological brain differences between adult stutterers and non-stutterers. BMC Neurology, 4, 23], in particular a reduction of the white matter anisotropy underlying the left sensorimotor cortex [Sommer, M., Koch, M. A., Paulus, W., Weiller, C., & Buchel, C. (2002). Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet, 360, 380-383] could be at the origin of persistent developmental stuttering (PDS). Because neural connections between the motor cortex and basal ganglia are implicated in speech motor functions, PDS could also be associated with a dysfunction in basal ganglia activity [Alm, P. (2004). Stuttering and the basal ganglia circuits: a critical review of possible relations. Journal of Communication Disorders, 37, 325-369]. This fMRI study reports a correlation between severity of stuttering and activity in the basal ganglia and shows that this activity is modified by fluency shaping therapy through long-term therapy effects that reflect speech production improvement. A model of dysfunction in stuttering and possible repair modes is proposed that accommodates the data presented here and observations previously made by us and by others.     

Nature against nurture: calcification in the right thalamus in a young man with anorexia nervosa and obsessive-compulsive personality disorder

This report describes the case of a young man with a large calcification in the right thalamus that was first diagnosed at 9 years of age. Case history reveals specific eating rituals and other obsessive-compulsive personality traits during the patient's childhood and adolescence, fulfilling diagnostic criteria of obsessive-compulsive personality disorder. After a critical life event the patient develops anorexia nervosa. We suggest that our case and further literature provide evidence for an involvement of specific thalamic structures, such as the dorsomedial nucleus, in the development of anorexia nervosa. Furthermore, the treatment of the patient by a combined psychotherapeutic and pharmacotherapeutic approach is described. We focus on the beneficial effect of the atypical antipsychotic olanzapine, which can induce weight gain by an increase of leptin levels.     

The Art of Becoming Human: Morality in Kant and Confucius

Kant and Confucius maintain that the art of becoming human is synonymous with the unending process of becoming moral. According to Kant, I must imagine a world in which the universality of my maxims were possible, while realizing that if such a world existed, then morality would disappear. Morality is an impossible possibility because it always meets resistance in our encounter with nature. According to Confucius, human beings become moral by integrating themselves into the already meaningful natural order that is tian 天. Like Kant, he upholds the dignity of human beings. For Kant this dignity rests on the autonomy of each human being’s reason, while for Confucius it is dependent upon our interconnection with each other, demanding ongoing self-extension. Despite these differences, the two thinkers would concur that our efforts at humanization are unceasing and that we may never fully live up to our human potential.     

The Effects of Adult Suggestion and Child Consistency on Young Children's Reports1

The purpose of the present study was to contrast the effects of children's response consistency and adult leading questions in a structured memory interview. Children (N = 70) who viewed a 2‐min video clip were asked 3 questions (leading, misleading, and neutral) related to the video. Children's responses (assent vs. deny) were predicted by the type of question asked by the adult (neutral, leading, and misleading), but not by the previous response given by the child or the child's age in months. Specifically, children assented the least often to misleading questions. Accuracy was predicted by both question type and in the last question–answer pair, children's previous response accuracy. These findings are discussed with relation to interview dynamics.     

Diagnostik in der Verhaltenstherapie

After an introduction, a short historical review of the development of behaviour therapy and the importance of categorical classification of mental disorders is given. We present different assessment approaches that are important in behaviour therapy. They comprise anamnesis, categorical classification, somatic differential diagnosis, psychometric methods, ratings scales, and diaries. As the core assessment strategy in cognitive behaviour therapy, functional behavioural analysis is introduced in detail, in which methods of horizontal analysis of behaviour (SORKC model proposed by Kanfer) and the vertical analysis of behaviour are explained. The importance of computer-based assessment and specific approaches of assessment within behaviour therapy for children and adolescents are presented. By way of conclusion, the prospects of possible new developments of assessment in behaviour therapy are outlined.     

Relationship commitment and its implications for unprotected sex among impoverished women living in shelters and low-income housing in Los Angeles County.

OBJECTIVE: To examine how relationship commitment among impoverished women is associated with their frequency of unprotected sex. DESIGN: Cross-sectional analyses were conducted on survey data from a probability sample of 445 women initially sampled from shelters and low-income housing in Los Angeles County. MAIN OUTCOME MEASURE: Frequency of unprotected sex in a typical month was derived as the product of 2 items: how often the woman had sex with her partner in a typical month and how often a male condom was used. RESULTS: For both sheltered and housed women, relationship commitment predicted more frequent engagement in unprotected sex with their partner, even after controlling for the type of relationship (primary vs. casual). However, this association could not be accounted for by perceived partner monogamy, ability to refuse unwanted sex, perceived HIV susceptibility, and condom use self-efficacy. Among housed women only, never asking the partner to use a condom partially accounted for more frequent engagement in unprotected sex among women with stronger relationship commitment. CONCLUSION: Results emphasize the importance of relationship commitment issues in HIV prevention interventions with impoverished women, and the need for a better understanding of relationship commitment and its influence on condom use in this population.     

Hypothetical and real consequences in experimental auctions for insurance against low-probability risks

Laboratory experiments have provided useful information about how people behave in risky situations. In particular, such experiments have allowed for the observation of many deviations from the predictions of expected utility theory. There is some dispute, however, over the effect of the use of real versus hypothetical money in these experiments and over the impact of experience. In this paper we describe auction experiments in which subjects faced a low-probability risk with either hypothetical or real-money consequences and varying amounts of experience. Using hypothetical payoffs resulted in behavior that provides a reasonable qualitative prediction of behavior with real consequences, but that seems to indicate a less diligent altitude toward spending the money as well as less concern about the risk.     

Psychiatry and psychotherapy in the many-sided contributions of Alexander Mette

Appreciating the personality and work of Alexander Mette, who founded together with Karl Bonhoeffer this journal, especially his psychiatric and psychotherapeutic inclinations as well as his influences on the development of our discipline are taken into consideration in the frame of his many-sided activities as a man of letters and cultural policy.     

Dynamic aspects of stimulus-response correspondence: evidence for two mechanisms involved in the Simon effect

It has been recently proposed that the time course of the Simon effect may vary across tasks, which might reflect different types of stimulus-response (S-R) transmissions (E. Wascher, U. Schatz, T. Kuder, & R. Verleger, 2001). The authors tested this notion in 4 experiments by comparing Simon effects evoked by horizontal and vertical S-R arrangements. The temporal properties of the effect, as well as lateralized readiness potential-difference waves, indicated a fast and transient influence of the horizontal, but a slow and sustained influence of the vertical spatial stimulus feature on performance. Additional evidence for this temporal dissociation was obtained in experiments that induced a shortening or lengthening of the mean response time. Thus, the data strongly indicate that there are 2 temporally dissociable mechanisms involved in generating the Simon effect for horizontal and vertical S-R relations.