Adverse childhood experiences and autonomic regulation in response to acute stress: the role of the sympathetic and parasympathetic nervous systems

Background and objectives: After a previous report demonstrated blunted heart rate (HR) reactivity in association with adverse childhood experiences (ACEs) [Voellmin, A., Winzeler, K., Hug, E., Wilhelm, F. H., Schaefer, V., Gaab, J.,?…?Bader, K. (2015). Blunted endocrine and cardiovascular reactivity in young healthy women reporting a history of childhood adversity. Psychoneuroendocrinology, 51, 58–67. doi:10.1016/j.psyneuen.2014.09.008], the present analysis aimed at clarifying the role of the sympathetic and parasympathetic branches of the autonomic nervous system in this relationship.

Design and Methods: One hundred eighteen healthy young women provided data on ACEs and underwent psychosocial stress testing. Systolic blood pressure (SBP) and respiratory sinus arrhythmia (RSA, quantified by high-frequency HR variability) were assessed as measures of sympathetic and parasympathetic cardiovascular activity, respectively. A mediation model was calculated to test the indirect effects of ACEs on HR via SBP and RSA.

Results: The effect of ACEs on HR reactivity was mediated by SBP reactivity but not by RSA reactivity. ACEs were associated with reduced SBP at rest.

Conclusions: ACEs were associated with down-regulation in a measure of sympathetic but no alteration in a measure of parasympathetic cardiovascular stress reactivity in adulthood. Future research will need to clarify whether this indicates risk or resilience.     

Observational Context of Mother-Child Interaction: Impact of a stress Context on Emotional Availability

Previous studies have found that a stressful observational context challenges the mother-child relationship, thus highlighting negative interactive behavior. However, the impact of observational context has only been investigated in infants and preschoolers without specifically using the Emotional Availability Scales. Nor have they explored whether the association of mother-child interaction with children’s emotional or behavioral problems depends on the observational context. We observed 140 mothers and their five to 12-year-old children in non-stressful free play and in a stressful task context. In general, dyads showed higher emotional availability in the task context compared to the free play. Specifically, mothers showed higher levels of Sensitivity, Structuring and Nonhostility, but lower levels of Nonintrusiveness during the task compared to the free play context; children showed higher levels of Responsiveness during the task than during free play. After controlling for dyadic stress, contextual effects decreased for all dimensions of emotional availability. The association of mother-child interaction with child problem behavior depended on the observational context. Specifically, we found maternal emotional availability during free play to be more strongly associated with child problem behavior than during the stressful task; however, emotional availability of the child was more strongly associated with problem behavior when obtained during the task. We conclude that context impacts on mother-child interactive behavior and also on the association of mother-child-interaction and child behavior. Stress is a relevant contextual factor influencing mother-child interactive behavior.     

Spatial specificity of tactile enhancement during reaching

Tactile signals on a hand that serves as movement goal are enhanced during movement planning and execution. Here, we examined how spatially specific tactile enhancement is when humans reach to their own static hand. Participants discriminated two brief and simultaneously presented tactile stimuli: a comparison stimulus on the left thumb or little finger from a reference stimulus on the sternum. Tactile stimuli were presented either during right-hand reaching towards the left thumb or little finger or while holding both hands still (baseline). Consistent with our previous findings, stimuli on the left hand were perceived stronger during movement than baseline. However, tactile enhancement was not stronger when the stimuli were presented on the digit that served as reach target, thus the perception across the whole hand was uniformly enhanced. In experiment 2, we also presented stimuli on the upper arm in half of the trials to reduce the expectation of the stimulus location. Tactile stimuli on the target hand, but not on the upper arm, were generally enhanced, supporting the idea of a spatial gradient of tactile enhancement. Overall, our findings argue for low spatial specificity of tactile enhancement at movement-relevant body parts, here the target hand.     

Mirror gazing in body dysmorphic disorder and healthy controls: effects of duration of gazing

Cognitive-behavioural models of body dysmorphic disorder (BDD) suggest that mirrors can act as a trigger for individuals with BDD, resulting in a specific mode of cognitive processing, characterised by an increase in self-focussed attention and associated distress. The aim of the current study was to investigate these factors experimentally by exposing participants with BDD (n = 25) and without BDD (n = 25) to a mirror in a controlled setting. An additional aim was to ascertain the role of duration of mirror gazing in the maintenance of distress and self-consciousness by manipulating the length of gazing (short check vs. long gazing). Findings demonstrated that contrary to what was predicted, not only participants with BDD, but also those without BDD experienced an increase in distress and self-focused attention upon exposure to the mirror. In addition, people without BDD, unlike those with BDD, experienced more distress when looking in the mirror for a long period of time as opposed to a short period of time. This lends some support to the idea that, for people with BDD, gazing in a mirror, regardless of duration, might act as an immediate trigger for an abnormal mode of processing and associated distress, and that this association has developed from past excessive mirror gazing. Further theoretical implications of these findings, as well as subsidiary research questions relating to additional cognitive factors are discussed.     

Neural correlates of metonymy resolution

Metonymies are exemplary models for complex semantic association processes at the sentence level. We investigated processing of metonymies using event-related functional magnetic resonance imaging (fMRI).During an 1.5 Tesla fMRI scan, 14 healthy subjects (12 female) read 124 short German sentences with either literal (like “Africa is arid”), metonymic (“Africa is hungry”), or nonsense (“Africa is woollen”) content. Sentences were constructed so that they obey certain grammatical, semantic, and plausibility conditions and were matched for word frequency, semantic association, length and syntactic structure. We concentrated on metonymies that were not yet fossilised; we also examined a wide variety of metonymic readings.Reading metonymies relative to literal sentences revealed signal changes in a predominantly left-lateralised fronto-temporal network with maxima in the left and right inferior frontal as well as left middle temporal gyri. Left inferior frontal activation may reflect both inference processes and access to world knowledge during metonymy resolution.     

Consciousness lost and found: subjective experiences in an unresponsive state

Anesthetic-induced changes in the neural activity of the brain have been recently utilized as a research model to investigate the neural mechanisms of phenomenal consciousness. However, the anesthesiologic definition of consciousness as “responsiveness to the environment” seems to sidestep the possibility that an unresponsive individual may have subjective experiences. The aim of the present study was to analyze subjective reports in sessions where sedation and the loss of responsiveness were induced by dexmedetomidine, propofol, sevoflurane or xenon in a nonsurgical experimental setting. After regaining responsiveness, participants recalled subjective experiences in almost 60% of sessions. During dexmedetomidine sessions, subjective experiences were associated with shallower “depth of sedation” as measured by an electroencephalography-derived anesthesia depth monitor. Results confirm that subjective experiences may occur during clinically defined unresponsiveness, and that studies aiming to investigate phenomenal consciousness under sedative and anesthetic effects should control the subjective state of unresponsive participants with post-recovery interviews.     

Cool and Hot Aspects of Executive Function in Childhood Obsessive-Compulsive Disorder

Aspects of executive functioning (EF) have been put forward as endophenotypes in obsessive- compulsive disorder (OCD) and meta-analyses support EF underperformance in adult samples. Childhood-onset OCD has been suggested to constitute a separate neurodevelopmental subtype of the disorder but studies on neuropsychological functioning in childhood OCD are limited. The aim of the present study was to investigate performance-based EF in pediatric OCD using observed and latent variable analyses. A case-control design was applied including 50 unmedicated children and adolescents with OCD aged 7–17 years of which 70% were female, 50 pairwise age and gender matched non-psychiatric controls (NP) and 38 children and adolescents with mixed anxiety disorders (MA). Participants underwent structured diagnostic interviews and assessment with a battery encompassing cool EF tasks of working memory, set shifting, inhibition, and planning, and hot EF tasks of decision making and dot probe paradigm affective interference. First, groups were compared on observed variables with multilevel mixed-effects linear regression and analysis of variance. Then the latent structure of cool EF was tested with confirmatory factor analysis (CFA) and groups were compared on the CFA scores. No significant differences between groups appeared on individual cool EF tasks. On the hot EF tasks the OCD group displayed significant interference effects on the dot probe paradigm OCD-specific stimuli relative to NP, but not compared to MA and no group differences emerged for decision making. In the CFA a one-factor solution showed best fit, but the groups did not differ significantly on the resulting latent variable. The present study does not support cool or hot EF impairments in childhood OCD.     

Effectiveness of a short audiovisual emotion recognition training program in adults

The ability to recognize emotions from others’ nonverbal behavior (emotion recognition ability, ERA) is crucial to successful social functioning. However, currently no self-administered ERA training for non-clinical adults covering multiple sensory channels exists. We conducted four studies in a lifespan sample of participants in the laboratory and online (total N?=?531) to examine the effectiveness of a short computer-based training for 14 different emotions using audiovisual clips of emotional expressions. Results showed that overall, young and middle-aged participants that had received the training scored significantly higher on facial, vocal, and audiovisual emotion recognition than the control groups. The training effect for audiovisual ERA persisted over 4 weeks. In older adults (59–90 years), however, the training had no effect. The new, brief training could be useful in applied settings such as professional training, at least for younger and middle-aged adults. In older adults, improving ERA might require a longer and more interactive intervention.     

‘Mr K’ – A successful case of analytic oriented therapy documented empirically: the role of the therapeutic relationship and reflexive self-awareness

A successful case of analytic treatment over the course of 250 sessions is described from different perspectives, including considerations from the two-year follow-up. The therapeutic alliance and the patient’s experiencing were evaluated. Pre-treatment diagnosis was validated via diagnostic interview. Symptoms and interpersonal problems were assessed at intervals. Data were analysed using two different time-series analyses. Aspects of agency with regard to mentalizing capacity were assessed with the Metacognitive Assessment Scale. We obtained the following main results: (1) Symptoms and interpersonal problems improved continuously until the end of treatment. Symptom severity fell to below the clinical cut-off. This successful outcome remained stable at the two-year follow-up. (2) The therapeutic relationship improved during the therapeutic process. (3) The patient’s capability for reflexive self-awareness, operationalized as experiencing, decreased. (4) The metacognitive mastery of the patient increased. The following conclusions were made after combining the empirical data with the clinical observations: (1) Mr K improved clinically in terms of symptoms, self-regulation and interpersonal problems as a result of his gaining affect control. (2) The patient’s experiencing does not capture a positive outcome in all cases. (3) Aspects of agency (i.e. metacognitive mastery) deserve further attention in psychoanalytic treatments.     

Reputation building: beyond our control? Inferences in consumers' ethical perception formation

• A company or brand's reputation is inherently linked to how ethically/unethically it is perceived to conduct its business. While it is generally assumed that consumers' ethical perceptions are either built on first‐hand experiences or other concrete information, this research demonstrates that reputation can be influenced by processes outside the company's direct control. The article is based on interviews with general consumers and presents the finding that, in the absence of concrete information or personal experience, consumers may infer ethical beliefs. Four distinct types of cues may instigate ethical inferences and act as surrogate indicators: product‐, company‐, category‐ and origin‐related cues. A framework that illustrates the hierarchical structure of the various cues depending on their level of specificity is presented. The results suggest that controlling corporate reputation becomes increasingly challenging. Implications for marketing practitioners and general managers are discussed and further research opportunities highlighted.

Copyright © 2010 John Wiley & Sons, Ltd.