Active avoidance conditioning in zebrafish (Danio rerio)

The zebrafish represents a potentially useful organism for studying genes involved in learning and memory function in vertebrates, because a number of genetic techniques in zebrafish have been developed to produce a wide variety of genetic mutants. While zebrafish mutants are being developed, behavioral studies on learning and memory function in zebrafish are in urgent need. The present study investigated active avoidance conditioning in normal zebrafish. Zebrafish were trained to swim from a lighted (CS) compartment to a dark compartment to avoid an electrical body shock (US) in a shuttle-box that consisted of a water-filled tank separated by an opaque barrier into two equal compartments. By varying the number of trials per training session and the duration of the intertrial interval, Experiments 1 and 2 showed that, with the CS, US, and intertrial interval being 12s, zebrafish learned avoidance responses within a training session consisting of 30 trials and retained the avoidance responses. Experiment 3 showed that zebrafish learned avoidance responses following the association between the CS of light and the US of shock in the avoidance conditioning paradigm. Using the avoidance conditioning paradigm, Experiment 4 investigated the amnestic effects of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor L-NAME in zebrafish. Experiment 4 showed that post-training injection of L-NAME significantly impaired retention of avoidance responses while MK-801 did not, confirming previous results with other vertebrates. The results of the present study suggest the similar involvements of neurochemicals in learning and memory among vertebrates. Thus, future studies with zebrafish mutants may identify genes involved in learning and memory in vertebrates.     

The contributory role of worry in emotion generation and dysregulation in generalized anxiety disorder

The role of worry in generalized anxiety disorder (GAD) has been posited to serve as an avoidance of emotional experience, and emotion regulation deficits in GAD have been found in several previous studies. It remains unclear whether those with GAD experience more dysregulated emotions during periods of euthymia and positive affect or whether these deficits occur only during periods of worry. Individuals with GAD (with and without co-occurring dysphoria) and non-anxious controls were randomly assigned to receive a worry, neutral, or relaxation induction. Following the induction, all participants viewed a film clip documented to elicit sadness. Intensity of emotions and emotion regulation were examined following the induction period and film clip. The results revealed that, regardless of co-occurring dysphoria, individuals with GAD in the worry condition experienced more intense depressed affect than GAD participants in the other conditions and controls participants. In contrast, presence of worry appeared to have less impact on indices of emotion dysregulation, which were greater in participants with GAD compared to controls, but largely insensitive to contextual effects of worry or of relaxation. Following film viewing, both GAD participants with and without dysphoria displayed poorer understanding, acceptance, and management of emotions than did controls. However, acceptance and management deficits were most pronounced in individuals with both GAD and co-occurring dysphoria. Implications for the role of emotions in conceptualization and treatment of GAD are discussed.     

The Erotic Eucharist

Pope Benedict XVI's encyclical Deus Caritas Est continues the magisterium's twentieth‐century shift from an act‐oriented, procreative approach to sexual ethics to what I will term a heterosexually personalistic one. Situating a heterosexual anthropology within a heterosexual cosmology, Benedict argues that just as God loves humanity with heterosexual eros, so must human beings love each other heterosexually. Although Benedict depends upon the explanatory power of heterosexuality, he perhaps unwittingly ends up depicting God's love not as iconically heterosexual, but as queer. In casting God's love as queer, I do not, even analogously, impute to God a type of homosexuality as Benedict does a heterosexuality. Instead, by drawing attention to the discursive specificity and historical instability of both homosexuality and heterosexuality, I use “queer” to recognize God's love as beyond categorization and as strange; it cannot be corralled into or contained by the historically specific notions of heterosexual and homosexual. But this essay does not merely deconstruct Benedict's heterosexually personalistic cosmology. It uncovers in Benedict's Eucharistic transfiguration of marital love a new and promising way of situating discussions about the ethics of sex.     

The Role of Hostile and Benevolent Sexism in Women's and Men's Perceptions of the Menstruating Woman

Perceptions of menstruating women were studied in a sample of 244, predominantly European American, college freshmen. Both women and men rated the menstruating woman, as compared with the average woman, as higher on the Neuroticism factor from Lippa's (1991) measure of the Big Five personality factors. Men also rated her as lower on the Openness, Agreeableness, and Conscientiousness factors, and women rated her lower on the Extraversion factor. Women rated her as perceiving herself as less masculine and more feminine. Both women and men rated her as less "energized" and "sexy," but more "irritable,""sad," and "angry." In addition, men rated her as less "clean and fresh,""nurturing," and "reasonable," and more "spacey" and "annoying." Significant relationships were found between negative impressions of the menstruating woman and the Hostile Sexism Scale ( Glick & Fiske, 1996 ). Although most ratings by men and women were negative, women perceived the menstruating woman as more "maternal,""strong," and "trustworthy."     

Caring for Someone with Depression: Attitudes and Clinical Practices of Australian Mental Health Workers

Many people who support a person with depression report struggling with the carer role and being dissatisfied with the inclusivity and lack of support provided by clinicians. However, little is known about what influences the support provided to Australian carers of people with depression. To investigate this, 119 Australian mental health workers completed a self‐report questionnaire to gather information on their attitudes towards, barriers experienced and current clinical practices when working with carers of people with depression. Participants' attitudes towards family members and carers were generally positive. Reported inclusive clinical practices varied. Participants identified a number of barriers to inclusive practice that were predominantly organisational in nature. Participants who perceived more barriers reported providing more clinical interventions. Attitudes and barriers were associated with the inclusive clinical practice of participants who worked with mental health consumers, but not participants who worked with family members and carers. Even among this sample of self‐selecting clinicians, there was room for significant improvement in rates of carer inclusive practice. Further research should explore not only what inhibits but also what enables the participation of family members and carers in the care and treatment process for people with depression.     

Evaluating the Effectiveness of the Self‐Administered Interview© for Witnesses with Autism Spectrum Disorder

The widely used evidence‐based police interviewing technique, the Cognitive Interview, is not effective for witnesses with autism spectrum disorder (ASD). The present study examined whether a modification of the Cognitive Interview that removes the social element, the Self‐Administered Interview^©, is more useful in facilitating recall by ASD witnesses. One of the main components of the Cognitive Interview is context reinstatement, where the witness follows verbal instructions from the interviewer to mentally recreate the personal and physical context that they experienced during the event. The present findings showed that this procedure is not effective for witnesses with ASD in SAI format in which the social component of its administration is removed. However, the SAI sketch plan component did elicit more correct details from the ASD group, although to a lesser degree than for the comparison group. Theoretical and practical implications of the findings are discussed. Copyright © 2014 John Wiley & Sons, Ltd.     

RT distributional analysis of cognitive-control-related brain activity in first-episode schizophrenia

Impairments in cognitive control are a defining feature of schizophrenia. Aspects of cognitive control include proactive control—the maintenance of task rules or goals to bias attention and maintain preparedness—and reactive control—the engagement of attention in reaction to changing cognitive demands. Proactive control is thought to be particularly impaired in schizophrenia. We sought to examine proactive and reactive control in schizophrenia, as measured by reaction time (RT) variability, and especially long RTs, which are thought to represent lapses in proactive control, during the Stroop paradigm. Furthermore, we sought to examine the neural underpinnings of lapses in proactive control and the subsequent engagement of reactive control in those with schizophrenia, as compared to healthy controls, using fMRI. We found that patients with schizophrenia displayed greater RT variability and more extremely long RTs than controls suggesting that proactive control was weaker in the schizophrenia than in the control group. All of the subjects engaged regions of the cognitive control network during long RTs, consistent with an engagement of reactive control following a failure in proactive control on these trials. The schizophrenia group, however, displayed significantly diminished activity in these regions relative to controls. Our results suggest increased failures in proactive control, but also impaired reactive control, in schizophrenia as compared to healthy subjects.