Does Symptom Linkage Density Predict Outcomes in Cognitive Therapy for Recurrent Depression?

Journal of Psychopathology and Behavioral Assessment - Acute-phase cognitive therapy (CT) is an efficacious treatment for major depressive disorder (MDD), but how CT helps patients is incompletely...     

Striatal sensitivity to personal responsibility in a regret-based decision-making task

Regret and relief are complex emotional states associated with the counterfactual processing of nonobtained outcomes in a decision-making situation. In the “actor effect,” a sense of agency and personal responsibility is thought to heighten these emotions. Using fMRI, we scanned volunteers (n = 22) as they played a task involving choices between two wheel-of-fortune gambles. We examined how neural responses to counterfactual outcomes were modulated by giving subjects the opportunity to change their minds, as a manipulation of personal responsibility. Satisfaction ratings to the outcomes were highly sensitive to the difference between the obtained and nonobtained outcome, and ratings following losses were lower on trials with the opportunity to change one’s mind. Outcome-related activity in the striatum and orbitofrontal cortex was positively related to the satisfaction ratings. The striatal response was modulated by the agency manipulation: Following losses, the striatal signal was significantly lower when the subject had the opportunity to change his/her mind. These results support the involvement of frontostriatal mechanisms in counterfactual thinking and highlight the sensitivity of the striatum to the effects of personal responsibility.     

Effects of concreteness and semantic relatedness on composite imagery ratings and cued recall

Day and Bellezza (1983) rejected a dual coding imagery explanation for the superior recall of concrete words because unrelated concrete pairs were rated lower in composite imagery but were still remembered better than related abstract pairs. We show that dual coding theory explains their results and our new findings using the same paradigm. In Experiment 1, 120 subjects rated imagery or relatedness for 108 pairs that varied in concreteness, pair relatedness, and associative strength. Incidental cued recall followed. Relatedness and strength affected imagery ratings, as did concreteness, and very low relatedness partly accounted for the low composite imagery ratings for unrelated concrete pairs. Concreteness and relatedness also affected recall, and suporior recall for unrelated concrete pairs occurred consistently under imagery but not under relatedness instructions. In Experiment 2, 40 subjects rated imagery value and recalled 24 pairs. Subsequent questioning indicated that composite images were retrieved better given stimuli from unrelated concrete than from related abstract pairs. These findings and Day and Bellezza’s original results are explained in terms of (1) imaginal and verbal associative processes, which jointly influence composite imagery ratings and recall, and (2) the critical role of stimulus concreteness during image retrieval and recall (i.e., the conceptual peg hypothesis).     

Salience network response to changes in emotional expressions of others is heightened during early adolescence: relevance for social functioning

Adolescence is a unique developmental period when the salience of social and emotional information becomes particularly pronounced. Although this increased sensitivity to social and emotional information has frequently been considered with respect to risk behaviors and psychopathology, evidence suggests that increased adolescent sensitivity to social and emotional cues may confer advantages. For example, greater sensitivity to shifts in the emotions of others is likely to promote flexible and adaptive social behavior. In this study, a sample of 54 children and adolescents (age 8–19 years) performed a delayed match‐to‐sample task for emotional faces while undergoing fMRI scanning. Recruitment of the anterior cingulate and anterior insula when the emotion of the probe face did not match the emotion held in memory followed a quadratic developmental pattern that peaked during early adolescence. These findings indicate meaningful developmental variation in the neural mechanisms underlying sensitivity to changes in the emotional expressions. Across all participants, greater activation of this network for changes in emotional expression was associated with less social anxiety and fewer social problems. These results suggest that the heightened salience of social and emotional information during adolescence may confer important advantages for social behavior, providing sensitivity to others’ emotions that facilitates flexible social responding.     

Are Deaf Dating Scripts Really Different from Those of Their Hearing Peers?

An initial study found that Deaf participants have a different definition of a date than the Traditional Sex Script (TSS). In the TSS, the man is viewed as the initiator who pushes for sex and the woman is expected to limit sex if they do not want to have intercourse; neither of these ideas were included in Deaf participants’ responses when asked what happens on a typical date. These findings may relate to early experiences in childhood. At an early age, hearing children are exposed to the TSS through popular culture. Deaf children are not exposed to these cues at the same level because of their lack of communication access. Here we compare Deaf college students to hearing college students to further investigate these issues using a more quantitative design.     

A nice surprise? Predictive processing and the active pursuit of novelty

Recent work in cognitive and computational neuroscience depicts human brains as devices that minimize prediction error signals: signals that encode the difference between actual and expected sensory stimulations. This raises a series of puzzles whose common theme concerns a potential misfit between this bedrock informationtheoretic vision and familiar facts about the attractions of the unexpected. We humans often seem to actively seek out surprising events, deliberately harvesting novel and exciting streams of sensory stimulation. Conversely, we often experience some wellexpected sensations as unpleasant and to-be-avoided. In this paper, I explore several core and variant forms of this puzzle, using them to display multiple interacting elements that together deliver a satisfying solution. That solution requires us to go beyond the discussion of simple information-theoretic imperatives (such as 'minimize long-term prediction error') and to recognize the essential role of species-specific prestructuring, epistemic foraging, and cultural practices in shaping the restless, curious, novelty-seeking human mind.     

Does Traumatic Brain Injury Attenuate the Exposure Therapy Process?

Research indicates that exposure therapy is efficacious for combat-related posttraumatic stress disorder (PTSD) comorbid with traumatic brain injury (TBI) as is shown by reduced PTSD treatment outcome scores. What is unknown, however, is whether the process of fear extinction is attenuated in veterans with TBI history. Increased PTSD symptomatology and possible cognitive deficits associated with TBI sequelae may indicate additional or longer exposure sessions to achieve habituation and extinction comparable to individuals without TBI history. As such, a more extensive course of treatment may be necessary to achieve comparable PTSD treatment outcome scores for individuals with TBI history. Using a sample of veterans with combat-related PTSD, some of whom were comorbid for TBI, this study compared process variables considered relevant to successful treatment outcome in exposure therapy. Individuals with and without TBI demonstrated similar rates of fear activation, length and number of exposure sessions, within-session habituation, between-session habituation, and extinction rate; results remained consistent when controlling for differential PTSD symptomatology. Furthermore, results indicated that self-perception of executive dysfunction did not impact the exposure process. Results suggest that individuals with PTSD and TBI history engage successfully and no differently in the exposure therapy process as compared to individuals with PTSD alone. Findings further support exposure therapy as a first-line treatment for combat-related PTSD regardless of TBI history.