Verb Comprehension Deficits in Probable Alzheimer's Disease

Studies of lexical comprehension in probable Alzheimer's disease (pAD) have focused almost exclusively on nouns. In the following preliminary study, we examined whether lexical comprehension for verbs is also impaired in 25 pAD patients. The semantic meaning of motion verbs, cognition verbs, and perception verbs was assessed with a triadic comparison task. Structural meaning associated with these verbs was evaluated by asking the patients to judge the coherence of sentence frames that accept these verbs naturally or awkwardly. We found that pAD patients are significantly impaired at identifying semantic relations among verbs. pAD patients also encountered significantly more difficulty judging the coherence of sentences than control subjects. Correlation and regression analyses demonstrated that semantic characteristics of verbs are projected from the verbs' sentence frames in control subjects, but there was minimal evidence for such a structural–semantic relationship in pAD. We consider several possible explanations for our preliminary observations of an impairment that has consequences for processing both semantic and structural aspects of verb meaning.     

Progressive changes in articulatory patterns in verbal apraxia: A longitudinal case study

This research reports findings in a 10-year study of an apraxic adult, who was one of five subjects described by Shankweiler and Harris, (Cortex, ,2 277–292, 1966). Confusion matrices and feature analysis were used to compare 1965 and 1975 performances. Results indicate that over the 10-year period, errors of place, manner, and omission were markedly reduced. Voicing errors, however, while reduced in total number, still constituted a significant percentage of the patient's residual errors. Implications of these findings are discussed.     

The effect of modification of expressive displays on vicarious emotional arousal

Several recent experiments have demonstrated that modulation of the facial expressive response is accompanied by changes in autonomic arousal and subjective response to painful stimuli. The present study asked whether facial self-regulation may also bring about changes in covert vicarious emotional experience. Three groups of subjects were exposed to a videotaped model displaying intermittent pain to shock in a differential vicarious autonomic conditioning paradigm. Subjects in the inhibit and amplify groups were asked, respectively, (a) to inhibit their facial muscles or (b) to pose a facial response of pain when the model was shocked. It was predicted that the inhibit group would show less autonomic arousal to the model's expressive display (empathy) and less conditioning (as measured by skin conductance and heart rate change), and the amplify group more empathy and conditioning, than a third group who was given no facial instruction. In fact, the amplify group showed more skin conductance arousal, heart rate acceleration, and activity in response to the model's expressive display of pain than did the other two groups (which were not different from each other), but no more autonomic or facial conditioning. The overall pattern of physiological data is interpreted as generally supportive of a facial feedback theory of emotion: where significant between-groups' differences were obtained in facial activity, as in vicarious instigation, autonomic arousal differences also emerged; where no expressive differences were obtained, as in vicarious conditioning, no differences in autonomic arousal were found.     

Tolerance to and residual effects of cocaine in squirrel monkeys depend on reinforcement-schedule parameter.

Lever pressing by 4 squirrel monkeys was maintained under a three-component multiple fixed-ratio schedule of food presentation; components differed with respect to ratio size. For each monkey, acute administration of cocaine (0.03 to 1.3 mg/kg, i.m.) produced dose-dependent decreases in overall response rate in each component. During repeated daily administration of 1.0 mg/kg of cocaine, tolerance developed to the rate-decreasing effects under each of the ratio contingencies, but developed to a greater extent and was evident in earlier parts of sessions for performance under the smaller ratios. Response rates of 2 monkeys increased above nondrug control levels despite the putative reinforcer not being consumed during the session. When saline or a smaller dose of cocaine was substituted for 1.0 mg/kg, response rates often were suppressed below nondrug control-level responding. This suppressive effect was observed in each monkey and was more likely to be observed and/or to be of greater magnitude in large-ratio components for 3 of the 4 monkeys. When saline was administered chronically at the end of the chronic-drug phase, response rates remained suppressed in the large-ratio component for 2 of the monkeys. There was, therefore, a schedule-dependent dissociation between behavioral tolerance and the residual effects: Tolerance was greater when small ratios were arranged, whereas the residual effects were more pronounced when larger ratios were arranged.