The associative-memory basis of cognitive skill learning: adult age differences

It has been established that memorizing common problems and their solutions underlies cognitive skill development, and that there are substantial age deficits in the rate of this learning. In a between-groups design, the authors compared learning rates for the same set of problems in skill (SK) training and paired-associate (PA) training. The authors found main effects due to condition (PA problems were acquired earlier) and to age (older adults' learning was delayed), but no condition-by-age interaction. The authors concluded that the age deficit in SK can be accounted for by the age deficit in associative memory; no further explanation is needed. The authors also analyzed fast and slow retrieves in SK and PA, and found that the frequency of fast retrieves did not differ in the two conditions. The overall advantage of PA was due to the occurrence of slow retrieves, which were absent in SK presumably because the skill algorithm displaces slow, explicit memory search in SK, but not fast, familiarity-based retrieval.     

Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure

We examined the ontogeny of the corticosterone response to (+)-methamphetamine in neonatal rats. In experiment-1, animals were injected with 10 mg/kg of (+)-methamphetamine or saline and plasma corticosterone levels were examined in separate groups 30 or 105 min later on postnatal day (P) 1, 3, 5, 7, 9, 11, 13, 15, 17, or 19. The adrenal response to methamphetamine was best described by a U-shaped function with the nadir of corticosterone release occurring between P7 and P13. Experiment-2 was similar except that the effect of four consecutive days of exposure to (+)-methamphetamine (four times daily at 2 h intervals with 10 mg/kg) was assessed with a single final dose early on the fifth day (i.e. P1-5, 3-7, 5-9, 7-11, 9-13, 11-15, 13-17, 15-19). The 30 min corticosterone response after multiple methamphetamine doses was augmented compared to single exposures, with the exception of the two earliest dosing intervals ending on P5 and P7, where the responses were lower. In addition, at 105 min, the levels of corticosterone were attenuated relative to a single drug administration. With the exception of animals receiving methamphetamine from P15 to P19, thymus weights were unaffected. The data demonstrate that (+)-methamphetamine is a robust activator of corticosterone release in developing animals and this release is extensively modified by age and previous drug exposure.     

Toward an Aesthetic Medicine: Developing a Core Medical Humanities Undergraduate Curriculum

The medical humanities are often implemented in the undergraduate medicine curriculum through injection of discrete option courses as compensation for an overdose of science. The medical humanities may be reformulated as process and perspective, rather than content, where the curriculum is viewed as an aesthetic text and learning as aesthetic and ethical identity formation. This article suggests that a "humanities" perspective may be inherent to the life sciences required for study of medicine. The medical humanities emerge as a revelation of value inherent to an aesthetic medicine taught and learned imaginatively.