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Different mechanisms of fear extinction dependent on length of time since fear acquisition
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Fear extinction is defined as a decline in conditioned fear responses (CRs) following nonreinforced exposure to a feared conditioned stimulus (CS). Behavioral evidence indicates that extinction is a form of inhibitory learning: Extinguished fear responses reappear with the passage of time (spontaneous recovery), a shift of context (renewal), and unsignaled presentations of the unconditioned stimulus (reinstatement). However, there also is evidence to suggest that extinction is an "unlearning" process corresponding to depotentiation of potentiated synapses within the amygdala. Because depotentiation is induced more readily at short intervals following LTP induction and is not inducible at all at a sufficient delay, it may be that extinction initiated shortly following fear acquisition preferentially engages depotentiation/"unlearning," whereas extinction initiated at longer delays recruits a different mechanism. We investigated this possibility through a series of behavioral experiments examining the recoverability of conditioned fear following extinction. Consistent with an inhibitory learning mechanism of extinction, rats extinguished 24-72 h following acquisition exhibited moderate to strong reinstatement, renewal, and spontaneous recovery. In contrast, and consistent with an erasure mechanism, rats extinguished 10 min to 1 h after acquisition exhibited little or no reinstatement, renewal, or spontaneous recovery. These data support a model in which different neural mechanisms are recruited depending on the temporal delay of fear extinction. 相似文献
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Environmental enrichment paradigms that incorporate cognitive stimulation, exercise, and motor learning benefit memory and synaptic plasticity across the rodent lifespan. However, the contribution each individual element of the enriched environment makes to enhancing memory and synaptic plasticity has yet to be delineated. Therefore, the current study tested the effects of three of these elements on memory and synaptic protein levels. Young female C57BL/6 mice were given 3h of daily exposure to either rodent toys (cognitive stimulation) or running wheels (exercise), or daily acrobatic training for 6 weeks prior to and throughout behavioral testing. Controls were group housed, but did not receive enrichment. Spatial working and reference memory were tested in a water-escape motivated radial arm maze. Levels of the presynaptic protein synaptophysin were then measured in frontoparietal cortex, hippocampus, striatum, and cerebellum. Exercise, but not cognitive stimulation or acrobat training, improved spatial working memory relative to controls, despite the fact that both exercise and cognitive stimulation increased synaptophysin levels in the neocortex and hippocampus. These data suggest that exercise alone is sufficient to improve working memory, and that enrichment-induced increases in synaptophysin levels may not be sufficient to improve working memory in young females. Spatial reference memory was unaffected by enrichment. Acrobat training had no effect on memory or synaptophysin levels, suggesting a minimal contribution of motor learning to the mnemonic and neuronal benefits of enrichment. These results provide the first evidence that different elements of the enriched environment have markedly distinct effects on spatial memory and synaptic alterations. 相似文献
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Rats' rates of leverpressing for low-concentration liquid-sucrose reinforcers in the first half of an experimental session increase when food pellet, rather than sucrose, reinforcers will be available in the second half. Experiment 1 determined that this induction effect was the outcome of food pellet reinforcement's increasing response rates, not of continued sucrose reinforcement's decreasing them. Experiments 2 and 3 showed that induction was primarily controlled by the conditions of reinforcement in the current session, not by those in the previous one. Experiment 4 showed little evidence that the induction was the outcome of Pavlovian processes. These results suggest that induction may occur because of processes operating at the level of the entire session. They also provide a link to a seemingly related area of study: contrast effects. Some of the results are consistent with what is known about contrast effects, but there are also several, yet unexplained differences. 相似文献
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Colonization has resulted in Maori occupying a vulnerable position in New Zealand society. Comparatively poor health, along with complex social and economic problems, is a reflection of this fundamental insecurity. This article aims to put forward a historical and developmental perspective for understanding some of the current health disparities experienced by Maori, by exploring the concepts of historical trauma, loss of land, and alternative theories of development from post-development theory. 相似文献
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Barriers to Mental Health Care: A 25‐Year Follow‐Up Study of the Orthodox Jewish Community
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Eliezer Schnall Solomon Kalkstein Ayelet Gottesman Karyn Feinberg Charles B. Schaeffer S. Shalom Feinberg 《Journal of multicultural counseling and development》2014,42(3):161-173
The current study is a 25‐year follow‐up to a mental health needs assessment in the often overlooked, but rapidly growing, Orthodox Jewish denomination. Results suggest increased acceptance of mental illness and its treatment and satisfaction with quality of care, along with decreased mistrust of the mental health field, belief that religion and psychiatry conflict, and tendency to attach stigmas to psychiatric problems. However, issues of stigma and affordability continue to be obstacles to treatment. El presente estudio es un seguimiento tras 25 años de una evaluación de necesidades de salud mental en la población frecuentemente ignorada, pero en crecimiento rápido, de individuos de denominación judía ortodoxa. Los resultados sugieren una mayor aceptación de enfermedades mentales y sus tratamientos, así como la satisfacción con la calidad de los cuidados, además de una reducción en la desconfianza hacia el campo de la salud mental, la creencia de que existe un conflicto entre religión y psiquiatría, y la tendencia a estigmatizar los problemas psiquiátricos. Sin embargo, problemas relacionados con la asequibilidad y el estigma continúan siendo obstáculos para el tratamiento. 相似文献
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Karyn Dayle Jones 《Journal of counseling and development : JCD》2010,88(2):220-226
In mental health, family, and community counseling settings, master's‐level counselors engage in unstructured clinical interviewing to develop diagnoses based on the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM‐IV‐TR; American Psychiatric Association, 2000). Although counselors receive education about diagnosis and the DSM classification system, the majority of them are not specifically trained in clinical interviewing. This article provides information about using the unstructured clinical interview to make a DSM‐IV‐TR diagnosis for adult clients with Axis I and Axis II disorders. 相似文献
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Laurie K. McLay Karyn G. France Jacqueline Knight Neville M. Blampied Brent Hastie 《Behavioral Interventions》2019,34(1):30-51
This study investigated the effectiveness of functional behavioral assessment (FBA)—informed interventions for sleep problems, particularly co‐sleeping, in children with autism spectrum disorder (ASD). Seven children, who exhibited multiple sleep problems including unwanted co‐sleeping, participated. FBA, based on information derived from interviews and parent‐recorded sleep diaries, was used to develop individualized case formulations upon which multicomponent, parent‐implemented interventions were based. These were evaluated using a single‐case, non‐concurrent multiple‐baseline‐across‐participants design. Improvements were observed across all sleep problems, including the elimination of co‐sleeping. Gains were maintained at follow‐up for five out of seven children, though two children did not complete intervention. Parents reported high levels of satisfaction with the program. FBA‐based interventions for sleep problems in children with ASD and their clinical implications are further discussed. 相似文献
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Karyn L. Wang Anya Johnson Helena Nguyen Robyn E. Goodwin Markus Groth 《Psychologie appliquee》2020,69(1):30-58
Opportunities to learn and apply new skills are generally considered a favourable job characteristic, but can there be too much of a good thing? In this paper, we draw on vitamin and resource perspectives to investigate a more nuanced perspective on where, when and why skill utilisation delivers value as a resource. Specifically, we examine whether skill utilisation exhibits non-linear relationships with job satisfaction and absenteeism in the presence of two different job demands: task workload, which captures the quantitative demands of work, and surface acting, which captures the qualitative demands of work. Using data from 278 hospital employees, we found that surface acting moderated the non-linear relationship between skill utilisation and absenteeism. Specifically, the relationship between skill utilisation and absenteeism became increasingly positive when surface acting was high, but not when surface acting was low. Interestingly, the linear relationship between skill utilisation and job satisfaction was less positive when surface acting was high. Task workload did not interact with skill utilisation to predict employee outcomes. Our findings highlight complexities in the relationship between job resources and demands and show that the value of skill utilisation changes under demanding conditions. 相似文献
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