Metachromatic Leukodystrophy and Nonverbal Learning Disability: Neuropsychological and Neuroradiological Findings in Heterozygous Carriers

Metachromatic leukodystrophy (MLD) is an autosomal recessive neurodegenerative disorder due to deficiency of the enzyme arylsulfatase A that leads to progressive, diffuse demyelination. The syndrome of nonverbal learning disability has been attributed to white matter abnormality and has been reported in children with this disorder and in some healthy family member carriers of gene. We examined the neuropsychologic profiles and MRIs of eight members of the family of a 7-year-old girl with this disease, all of whom were heterozygous carriers of the mutation and five of whom were also carriers of the MLD pseudodeficiency gene. All had low normal levels of arylsulfatase A, and seven of the eight had average or better profiles across all assessed neuropsychological domains. The patient's younger sister had a profile with features of the syndrome of nonverbal learning disability despite a normal MRI, whereas two members with minor white matter findings did not. This family does not provide evidence for the syndrome of nonverbal learning disability in heterozygous carriers of the gene for MLD, even when associated with the MLD pseudodeficiency gene.     

Does Particularism Solve the Moral Problem?

Abstract

Moral cognitivism, internalism about moral judgements, and Humeanism about motivating reasons all possess attractions.Yet they cannot all be true.This is the so–called moral problem. Dancy offers an interesting particularist response to the moral problem. However, we argue that this response, first, provides an inadequate basis for the distinction between motivating states and states necessary for motivation although not themselves motivators; second, draws no support from considerations about weakness of the will; and third, involves an implausible account of desire.We conclude that particularism ú whatever other attractions it may have ú does not solve the moral problem.     

Cognitive Neurorehabilitation of HIV-associated Neurocognitive Disorders: A Qualitative Review and Call to Action

Despite significant advances in the virologic management of HIV infection over the last two decades, effective treatments for HIV-associated neurocognitive disorders (HAND) remain elusive. While pharmacological interventions have yielded some success in improving neurocognitive outcomes in HIV, there is a dearth of rigorous studies examining the efficacy of cognitive rehabilitation for remediating HIV-associated neurocognitive impairment. This qualitative review summarizes and critiques the emerging literature on cognitive and behavioral treatments for HAND, which provides many reasons for optimism, but also has major limitations that underscore the scope of the work that lies ahead. Considering the notable real-world consequences of HAND, the development, validation, and clinical deployment of cognitive neurorehabilitation interventions tailored to the needs of persons living with HIV infection is a priority for clinical neuroAIDS investigators. In describing potential future directions for this endeavor, particular attention was paid to the application of cognitive neuropsychological principles in developing theory-driven approaches to managing HAND, improving everyday functioning, and enhancing HIV health outcomes.     

Moral Clarity in Narratives Elicits Greater Cooperation than Moral Ambiguity

In disciplines such as moral psychology and media theory, investigations of moral clarity versus ambiguity in narratives are increasingly important. Untested mechanisms have been proposed for how moral clarity and ambiguity might affect audiences. Based on literature regarding joint action and coordinated experiences, we reason that morally clear narratives elicit coordinated responses across audience members, which should increase within-group cooperation. By contrast, we reason that morally ambiguous narratives elicit divergent, uncoordinated responses across audience members, and this experience decreases cooperation. We conducted three independent studies (one using short text narratives, one using feature-length films, and one using morally and emotionally neutral stimuli). Results indicate that moral clarity is indeed associated with subsequently higher levels of group cooperation than moral ambiguity, and the effect cannot be attributed to changes in affect or moral priming.     

Collected Stories: Play in Four Acts

This article evolved from a group process where members of a psychoanalytic institute were faced with planning workshops for a professional weekend around the theme of “play.” The workshop that evolved consisted of four vignettes of play taking place in the therapeutic sessions of a child, an adolescent, an adult, and an elderly woman. The discussion of these vignettes that began at the conference and then was developed for this article focuses on tracing the development of play from childhood into adulthood (Mayes & Cohen, 1996; Russ, 2004) and on the relationship between play and the development of reflective functioning (Fonagy & Target, 1996). One area of particular interest that was focused upon was the use of play with adults who are described as “concrete,” people who function, at times, at a level of differentiation more typical of a young child. Play is described as being particularly helpful in facilitating a more differentiated and, thus, more reflective mode of psychic functioning for this group of individuals as well as for people at all levels of development.     

Ethical social justice: Do the ends justify the means?

This article offers an ethical decision‐making model, informed by community psychology values, as a means for guiding psychologists when engaging in social justice‐oriented work. The applicability of this model is demonstrated through a case analysis elucidating how America's psychologists individually and collectively arrived at the decision to endorse torture—ostensibly as a means for preventing terrorism. Critics have wondered how the American Psychological Association succumbed to these involvements, and how to prevent such ethical lapses in the future. Unfortunately, the American Psychological Association's ethical codes fail to provide explicit guidance for psychologists' involvement in social justice work that impacts communities and systems. To address this gap, we present a values‐driven, ethical decision‐making framework that may be used to guide psychologists' future practices. This framework infuses fundamental community psychology values (i.e., caring and compassion; health; self‐determination and participation, human diversity, social justice; and critical reflexivity) into a 9‐step model.     

Trait anger moderates the impact of anger-associated rumination on social well-being

In this study, we examined whether people’s social well-being is influenced by hostile versus nonhostile goals that people report pursuing when experiencing anger-associated rumination. Moreover, we investigated the impact of trait anger and trait anger rumination on the relationship between anger rumination and perceived social well-being. Participants were 93 students who were equipped with hand-held computers for 28 days to assess anger-related rumination and its social consequences in daily life. Results showed that hostile goal pursuit per se did not affect perceived social well-being. However, impairment of social well-being following hostile rumination was moderated by trait anger. Findings are consistent with recent cognitive models of trait anger and anger rumination.     

Does latent deprivation lead to psychological distress? Investigating Jahoda's model in a four‐wave study

Unemployment has serious negative effects on psychological health, and yet the underlying mechanisms remain unknown. According to the latent deprivation model, it is the lack of latent benefits of work associated with unemployment, which leads to psychological distress. In a four‐wave study among employed persons, unemployed persons, and persons out of the labour force (OLF) (N_T1= 1,026), this assumption was tested cross‐sectionally as well as longitudinally. Multiple mediation analyses show the expected differences in distress between the employed, unemployed, and OLF persons and indicate that part of this difference can be explained by differential access to the latent benefits. Furthermore, cross‐lagged structural equation modelling confirms that a deprivation of latent benefits leads to a decrease in psychological health 6 months later. Findings regarding the different quality of the latent benefits in relation to each other and over time when predicting psychological health are discussed.     

Intrinsic Value and the Last Last Man

Even if you were the last person on Earth, you should not cut down all the trees—or so goes the Last Man thought experiment, which has been taken to show that nature has intrinsic value. But ‘Last Man’ is caught on a dilemma. If Last Man is too far inside the anthropocentric circle, so to speak, his actions cannot be indicative of intrinsic value (a Local problem). If Last Man is cast too far outside the anthropocentric circle, though, then value terms lose their cogency (a Global problem). The experiment must satisfy conditions in a seemingly impossible ‘goldilocks’ zone. To this end I propose a new version, the Ultramodal Last Man, which appeals to Routley's work in metaphysics and non‐classical logic. With this ‘Last Last Man’, I argue that the Local /Global dilemma is resolved: impossible equations balance in ultramodal space. For defenders and critics alike, this helps to clarify the demands of intrinsic value, and renews a role for non‐standard logics in value theory.