Linguistic and nonlinguistic impairments in writing: a comparison of patients with focal and multifocal CNS disorders

The hypothesis that the language disorder in Alzheimer's disease (AD) depends on degenerative brain changes in classical left-hemisphere language zones was tested by comparing the written language performances of a group of AD patients with mild-moderate dementia and left-hemisphere stroke patients with equally severe naming and auditory comprehension deficits who were in varying stages of recovery from Wernicke's aphasia. The results indicated significant qualitative group differences in performances between tasks and in errors within tasks. The findings are consistent with hypothesized disruption of more diffusely organized neurolinguistic systems in AD. The hypothesis that the language disorder in AD represents an exaggeration of the pattern of language change in normal aging was also examined by comparing the performances of AD patients to the changes that occur with very advanced normal aging. The data indicate convergence between AD and very elderly healthy subjects in some aspects of written language production.     

Longitudinal neuropsychological report of aphasia following left-subcortical hemorrhage

The neuropsychological assessments of a patient with language disturbance following left thalamic-putaminal hemorrhage over a $\text{2}\text{1}\text{2}\text{-}\text{year}$ period are presented together with premorbid measures of performance. Findings indicate that behavioral deficits which are both linguistic and nonlinguistic in nature differ from cortical aphasic syndromes in symptomatology and recovery course. The deficit pattern is also unlike that in other reported cases of left-subcortical lesions. Persistent dysarthria with fluent speech, limitation of verbal span and repetition, agraphia and anomia, and disturbances in self-regulation of behavior were noted, in addition to recovery of an initially severe auditory comprehension deficit. A distinguishing feature of this case was the relative preservation of reading comprehension in all four assessments.     

When do professional psychologists need professional programmers’ tools?

It is fairly straightforward to write a small program for a small computer, even using a relatively slow and unstructured language such as BASIC. However, current experiments in psychopharmacology require the system integration and data management services provided by large programs running on 256K microcomputers, and the efficient development of such programs requires the use of structured languages such as Pascal.     

Feature distribution and background knowledge in category learning

Three experiments examined the interactions of category structure and prior knowledge in category learning.Experiment 1 examined the distribution of atypical or 'crossover' features in category learning. In real categories, crossover features may be unevenly distributed found primarily in very unusual examples of a category (like whales or ostriches). In contrast, in many psychology experiments, each item has exactly one crossover feature. Even versus uneven distribution of crossover features did not affect category learning when the features were neutral. However, when the features were connected by prior knowledge, it was much harder for subjects to learn the structure with the uneven distribution of crossover features. Experiments 2 and 3 found similar results with a slightly less uneven condition. We conclude that learning is a function of the interaction of category structure and prior knowledge rather than either one alone. Furthermore, knowledge benefits learning even when the category contains contradictions of the knowledge, so long as the contradictions are not very salient.     

Self-Attitudes and Suicidal Behavior

Findings are reported concerning the hypothesized relationship between adoption of suicidal responses (ideation, threats, attempts) and antecedent negative self-attitudes. Data were provided by junior high school student (N = 3,148) responses to questionnaires administered three times at annual intervals. Antecedent negative self-attitudes were measured by a seven-item self-derogation scale at the first testing. Adoption of suicidal responses was indicated by earlier denial and subsequent affirmation of the response (self-reports). Findings indicate that suicidal behaviors are responses (whether or not subsequently continued) to experiences of negative self-attitudes in the more recent past. However, whether or not suicidal behaviors are related to self-derogating feelings in the more remote past can be seen as a function of a sex-social-class-mode of suicidal response interaction.     

Controlling attention to gaze and arrows in childhood: an fMRI study of typical development and Autism Spectrum Disorders

Functional magnetic resonance imaging was used to examine functional anatomy of attention to social (eye gaze) and nonsocial (arrow) communicative stimuli in late childhood and in a disorder defined by atypical processing of social stimuli, Autism Spectrum Disorders (ASD). Children responded to a target word ('LEFT'/'RIGHT') in the context of a distracting arrow or averted gaze pointing in a direction that was congruent, incongruent, or neutral (bar without arrowheads, central gaze) relative to the target word. Despite being irrelevant to the target task, both arrow and averted gaze facilitated responses (Congruent vs. Neutral trials) to the same extent in the two groups and led to interference (Incongruent vs. Congruent trials), which was greater from arrows in ASD than control children. In the brain, interaction between group and distracter-domain was observed in frontal-temporal regions during facilitation and frontal-striatal regions during interference. During facilitation, regions associated with attention to gaze in control children (left superior temporal sulcus, premotor) were associated with attention to arrows in ASD children; gaze was associated with medial temporal involvement in ASD children. During interference, regions associated with arrows in control children (anterior cingulate, right caudate) were activated in response to gaze in ASD children; further, left dorsolateral prefrontal cortex, a region not observed in control children, was activated during gaze-interference in ASD children. Thus, functional anatomy was atypical in ASD children during spontaneous processing of social and nonsocial communicative cues.