从神经可塑性的视角看压力与疾病的关系

压力致病是一个复杂的过程,涉及到与多种致病因素的相互作用、多个器官系统的激活和反馈、不同发育阶段对疾病的易感性等。这个过程中,神经可塑性起着重要的调节作用。本文以神经可塑性为切入点,阐述了压力、发育阶段、个人发展、疾病发生之间的关系。     

主体与自我——记北京大学纪念胡塞尔诞辰150周年哲学讨论会

2009年4月18日在北京大学举行了以“主体与自我”为主题的纪念胡塞尔诞辰150周年哲学讨论会。围绕大会的主题,学者们对胡塞尔的现象学展开了深入的探讨。     

Spatial updating in superimposed real and virtual environments

Wang (2004) showed that people do not always simultaneously update their relationships to real and imagined environments in a dual-environment situation. Employing the same paradigm, we examined whether spatial updating operates on virtual reality as it does on a real or fictitious environment. Participants learned target locations in a real room and a virtual kitchen. Then they turned to face targets either in the room or in the kitchen, while blindfolded, and pointed to the targets before and after turning. Participants kept track of their orientation in both environments equally efficiently, regardless of explicit instructions. In contrast, when the real environment was described verbally but not directly perceived, participants automatically updated the virtual kitchen but not the room. These results suggest that people automatically update a virtual environment as they do a real one when the two environments are superimposed. The automaticity of spatial updating is discussed.     

医务社会工作对疾病治疗康复的介入思考

医务社会工作是适应新医学模式为病人提供专业化服务的一种职业,在疾病的治疗与康复工作中有着重要功能和角色作用,对顺利实现治疗康复目标、缓解生理痛苦、提供心理支持,延长生命或提高生活质量,努力回归社会均发挥着不可替代的促进作用.随着我国医学和社会的发展,新医学模式下的医务社会工作介入,必将成为普遍趋势.     

学习困难的ERP研究

事件相关脑电位（Event—related potentials,ERPs）是研究心理学和认知神经科学的重要技术手段,将该技术用于学习困难的脑机制的研究,有助于发现学习困难的神经机制。研究表明,学习困难者的P300波幅较小,潜伏期较长。学习困难者的MMN波幅比控制组小,在信息的自动加工方面存在缺陷。在单词命名任务中,学习困难者的N400较小,而且不同类型学习困难者的波幅和潜伏期存在明显差异。     

从卡介苗成功治疗膀胱癌论肿瘤的免疫治疗

卡介苗(BCG)膀胱内灌注是治疗浅表性膀胱癌一种最有效的方法。通过对治疗后的监测发现,卡介苗灌注后可引发肿瘤部位显著的固有免疫和适应性免疫细胞反应,体内大多数的抗肿瘤免疫效应细胞参与这一反应过程。这一结果表明,有效的肿瘤免疫治疗必须由固有免疫和适应性免疫细胞协同作用才能完成。     

On the study of foreign philosophy in Chinese cultural construction and its future

Since the “Conference on Foreign Philosophy” held in Wuhu in October 1978, the study of foreign philosophy in China has undergone a prosperous stage. This article discusses the significance of the study of foreign philosophy in the context of renovation, transformation and remolding of Chinese contemporary culture, explores the role of the discipline in the context of Chinese cultural construction, and anticipates the future of this discipline. A cross-cultural perspective is needed for a proper understanding of the significance of the learning and study of foreign philosophy in Chinese cultural construction; otherwise we might fall into cultural conservationism. Secondly, to make philosophy and social sciences prosperous is also a task for foreign philosophy studies, and whether or not foreign philosophy can be well studied should be a mark of the prosperousness of the construction of Chinese culture. Finally, philosophy is a product of human beings and should eventually serve human beings. Chinese culture should open itself up to the world and so should foreign philosophy studies in China. __________ Translated from Jiangxi Shehui Kexue 江西社会科学 (Jiangxi Social Sciences), 2005 (2) by Chen Yuehua & Ma Minghui     

Decreased approach motivation in depression

The present study examined relations between choice preference and reaction time to emotionally valenced words, dysphoric symptoms (BDI), and dysfunctional attitudes (DAS) in clinically depressed (CD; n= 61), previously depressed (PD; n= 42), and never depressed controls (ND; n= 46). The results showed: (1) NDs and PDs exhibited a choice preference for the relatively more positive words and differed significantly from CDs; (2) PDs and CDs exhibited longer reaction time and differed significantly from NDs; and (3) BDI and DAS were positively associated with reaction time to positively valenced words, whereas no associations were found for reaction time to negatively valenced words. The increased reaction time, in PDs and CDs, is discussed as a possible vulnerability factor to depression, which may be related to decreased approach motivation.     

Updating egocentric representations in human navigation

Seven experiments tested whether human navigation depends on enduring representations, or on momentary egocentric representations that are updated as one moves. Human subjects pointed to unseen targets, either while remaining oriented or after they had been disoriented by self-rotation. Disorientation reduced not only the absolute accuracy of pointing to all objects ('heading error') but also the relative accuracy of pointing to different objects ('configuration error'). A single light providing a directional cue reduced both heading and configuration errors if it was present throughout the experiment. If the light was present during learning and test but absent during the disorientation procedure, however, subjects showed low heading errors (indicating that they reoriented by the light) but high configuration errors (indicating that they failed to retrieve an accurate cognitive map of their surroundings). These findings provide evidence that object locations are represented egocentrically. Nevertheless, disorientation had little effect on the coherence of pointing to different room corners, suggesting both (a) that the disorientation effect on representations of object locations is not due to the experimental paradigm and (b) that room geometry is captured by an enduring representation. These findings cast doubt on the view that accurate navigation depends primarily on an enduring, observer-free cognitive map, for humans construct such a representation of extended surfaces but not of objects. Like insects, humans represent the egocentric distances and directions of objects and continuously update these representations as they move. The principal evolutionary advance in animal navigation may concern the number of unseen targets whose egocentric directions and distances can be represented and updated simultaneously, rather than a qualitative shift in navigation toward reliance on an allocentric map.     

管仲生年考

本文从民间传说入手,对照史籍,探求管仲生年。