社会认知的神经基础

人类的社会技能高于其它任何动物,能够形成对社会环境的高级表征,并能利用这些表征进行十分灵活的推理判断。但是社会认知的神经基础目前仍不十分明了。来自于人类和其它灵长类动物的研究已经发现有一些脑结构（如杏仁核、前额叶、颞上沟、扣带前回等）在社会认知中起着特殊重要的作用。此外,越来越多的研究表明其它一些脑区结构（如右侧躯体体感区、岛叶、基底节、白质等）也共同参与社会认知加工过程。文章对近年来关于社会认知的神经基础研究做了较为详细的综述。     

Psychometric evaluation and experimental validation of the statistics anxiety rating scale

The Statistics Anxiety Rating Scale (STARS) was adapted into German to examine its psychometric properties (n = 400). Two validation studies (n = 66, n = 96) were conducted to examine its criterion-related validity. The psychometric properties of the questionnaire were very similar to those previously reported for the original English version in various countries and other language versions. Confirmatory factor analysis indicated 2 second-order factors: One was more closely related to anxiety and the other was more closely related to negative attitudes toward statistics. Predictive validity of the STARS was shown both in an experimental exam-like situation in the laboratory and during a real examination situation. Taken together, the findings indicate that statistics anxiety as assessed by the STARS is a useful construct that is more than just an expression of a more general disposition to anxiety.     

Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout

The synaptic Ras/Rap-GTPase-activating protein (SynGAP1) plays a unique role in regulating specific downstream intracellular events in response to N-methyl-D-aspartate receptor (NMDAR) activation. Constitutive heterozygous loss of SynGAP1 disrupts NMDAR-mediated physiological and behavioral processes, but the disruptions might be of developmental origin. Therefore, the precise role of SynGAP1 in the adult brain, including its relative functional significance within specific brain regions, remains unexplored. The present study constitutes the first attempt in achieving adult hippocampal-specific SynGAP1 knockout using the Cre/loxP approach. Here, we report that this manipulation led to a significant numerical increase in both small and large GluA1 and NR1 immunoreactive clusters, many of which were non-opposed to presynaptic terminals. In parallel, the observed marked decline in the amplitude of spontaneous excitatory currents (sEPSCs) and inter-event intervals supported the impression that SynGAP1 loss might facilitate the accumulation of extrasynaptic glutamatergic receptors. In addition, SynGAP1-mediated signaling appears to be critical for the proper integration and survival of newborn neurons. The manipulation impaired reversal learning in the probe test of the water maze and induced a delay-dependent impairment in spatial recognition memory. It did not significantly affect anxiety or reference memory acquisition but induced a substantial elevation in spontaneous locomotor activity in the open field test. Thus, the present study demonstrates the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR and hippocampal integrity.     

随机临床试验中伦理问题的探讨

随着我国的药物临床试验过程逐渐完善,药物临床试验水平不断提高,但伦理学方面并不十分完善.临床研究者和受试者应该明确自己的权益和义务,并在药物随机临床试验中,使受试者的权益得到更好的保护.本文论述并总结了药物临床试验中出现的问题,并提出了改进措施.     

记忆编码策略对心境一致性记忆的调节作用

情绪对记忆的影响会受记忆编码策略的调节。本研究通过2个实验探讨编码策略对心境一致性记忆的调节作用。实验1和实验2均采用2（编码策略：提取练习策略、重复学习策略）×2（词性：消极词、中性词）的实验设计,分别探讨了不同记忆编码策略对普通大学生（实验1）和非临床抑郁大学生（实验2）心境一致性记忆的影响。结果发现：无论是被成功诱导出抑郁情绪的普通大学生,还是非临床抑郁倾向大学生,使用重复学习策略时回忆出的消极词均显著多于中性词,表现出显著的心境一致性记忆,而使用提取练习策略时回忆出的消极词和中性词没有显著性差异,未表现出心境一致性记忆。实验结果表明,记忆编码策略对心境一致性记忆具有调节作用,提取练习策略能够抑制心境一致性记忆。研究结果指明了心境一致性记忆的边界条件,并对非临床抑郁个体的学习与记忆具有重要的启示。     

Analysis of individual variations in the classical horizontal-vertical illusion

In the horizontal-vertical illusion (HVI), the length of the vertical line is overestimated, whereas in the bisection illusion (BI), the horizontal bisecting line is expected to be overestimated. Here, only half of our 22 observers showed the expected BI, whereas the other half underestimated the bisecting line. Observers also differed in their judgments of the strength of the HVI: The HVI was stronger for observers showing the classical bisection effect, and weaker or absent for those underestimating the bisecting line. To account for these results, we used a linear model to individually estimate the strength of two putative factors underlying both illusions. Whereas the strength of the HVI and BI were highly correlated, the estimated factors were uncorrelated. Therefore, in two control experiments, we then measured the pure horizontal-vertical (pHVI) and bisection (pBI) illusions. A significant correlation between the estimated factors and the measured illusion variants was found. Results were robust against variations of contrast, repetitive presentations, and choice of adjusted line. Thus, the classical HVI as an additive combination of two independent factors was confirmed, but we found considerable interindividual variations in the strength of the illusions. The results stress the importance of analyzing individual data rather than taking sample means for understanding these illusions.     

Knocking on the Outgroup's Door: Seeking Outgroup Help Under Conditions of Task or Relational Conflict

Three studies investigated the willingness to seek help from another group in situations where collaborative goals are undermined by task or relational conflicts between the groups. Compared to task conflict, relational conflict was argued to trigger a striving for more autonomy. The results from three experiments (N = 82, N = 65, and N = 62) supported the prediction that relational conflict, compared to task conflict, promotes more help avoidance, in particular avoidance of dependency-oriented help (a full solution). As expected, no difference was found for the willingness to seek autonomy-oriented help (a hint) from the other group.     

Altered topological patterns of large-scale brain functional networks during passive hyperthermia

In this study, we simulated environmental heat exposure to 18 participants, and obtained functional magnetic resonance image (fMRI) data during resting state. Brain functional networks were constructed over a wide range of sparsity threshold according to a prior atlas dividing the whole cerebrum into 90 regions. Results of graph theoretical approaches showed that although brain networks in both normal and hyperthermia conditions exhibited economical small-world property, significant alterations in both global and nodal network metrics were demonstrated during hyperthermia. Specifically, a lower clustering coefficient, maintained shortest path length, a lower small-worldness, a lower mean local efficiency were found, indicating a tendency shift to a randomized network. Additionally, significant alterations in nodal efficiency were found in bilateral gyrus rectus, bilateral parahippocampal gyrus, bilateral insula, right caudate nucleus, bilateral putamen, left temporal pole of middle temporal gyrus, right inferior temporal gyrus. In consideration of physiological system changes, we found that the alterations of normalized clustering coefficient, small-worldness, mean normalized local efficiency were significantly correlated with the rectal temperature alteration, but failed to obtain significant correlations with the weight loss. More importantly, behavioral attention network test (ANT) after MRI scanning showed that the ANT effects were altered and correlated with the alterations of some global metrics (normalized shortest path length and normalized global efficiency) and prefrontal nodal efficiency (right dorsolateral superior frontal gyrus, right middle frontal gyrus and left orbital inferior frontal gyrus), implying behavioral deficits in executive control effects and maintained alerting and orienting effects during passive hyperthermia. The present study provided the first evidence for human brain functional disorder during passive hyperthermia according to graph theoretical analysis using resting-state fMRI.     

Toward a liberal socialist cosmopolitan nationalism

I explicate and defend a form of liberal socialist nationalism. It is also a nationalism which is cosmopolitan. Explication and explanation are crucially in order here, for it is not unreasonable to believe that ‘cosmopolitan nationalism’ and ‘liberal socialist nationalism’ and even ‘liberal nationalism’ are oxymoronic. Against that I argue that there is a straightforward understanding of these concepts and their relations to each other that does not have inconsistencies or even paradoxes. Liberal socialism properly understood goes well with cosmopolitanism (both moral and institutional), and there are plausible and attractive forms of both liberalism and socialism that go together. Moreover, the only candidate for a nationalism that would survive careful reflective inquiry is a liberal nationalism: a nationalism which is neither ethnic nor civic. It is widely believed, however, that even a liberal nationalism is incompatible with cosmopolitanism. I contend in a series of arguments that in contexts where nationalism is rightly on the agenda the form that it should take is that of a liberal nationalism, and it is further argued that to be viable, nationalism requires cosmopolitanism.     

An un‐Rortyan defence of Rorty's pragmatism

An identification is made of the core metaphilosophical, philosophical, and intellectual history theses in Richard Rorty's pragmatism. Their rationale is displayed and it is argued that his metaphilosophical theses are very much dependent on certain of his non‐metaphilosophical philosophical theses, most centrally his anti‐representationalism. Questions emerge about the status and justification of these theses. Rorty, in his programmatic pronouncements, resists providing a vindication of them. Seeking to avoid what has been called performative contradictions, he regards it as sufficient to provide the best narrative going of what is to be said here. It is argued that a more straightforward defence can be provided that does not depart from his holism or his historicism with its setting aside of claims of necessity.