Involvement of BDNF receptor TrkB in spatial memory formation

The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several tyrosine kinases including a Src-family tyrosine kinase Fyn. Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which also enhances hippocampal synaptic transmission and efficacy by increasing NMDA receptor activity. Here, we show that Fyn is a key molecule linking the BDNF receptor TrkB with NMDA receptors, which play an important role in spatial memory formation in a radial arm maze. Spatial learning induced phosphorylation of TrkB, Fyn, and NR2B, but not NR2A, in the hippocampus. Fyn was coimmunoprecipitated with TrkB and NR2B, and this association was increased in well-trained rats compared with control animals. Continuous intracerebroventricular infusion of PP2, a tyrosine kinase inhibitor, in rats delayed memory acquisition in the radial arm maze, but PP2-treated animals reached the same level of learning as the controls. The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus.     

Holistic thinking is not the whole story: alternative or adjunct approaches for increasing the accuracy of legal evaluations

There are a number of very helpful, but often underutilized, principles and procedures that can augment decision making in clinical and legal settings. Psychologists often restrict their range of decision-making strategies and options--at the cost of maximizing diagnostic and predictive accuracy--in part as the result of "ontological-epistemological one-worldedness" (O-E O-W). However, no philosophical, logical, or scientific necessity demands strict consistency between views regarding the nature of psychological phenomena and views about how to best assess or learn about those phenomena. Relaxing this unnecessary and largely psychologically-based O-E O-W may promote greater comfort with and utilization of the methods that are discussed in this article for increasing judgmental accuracy.     

The abbreviated multidimensional acculturation scale: empirical validation with two Latino/Latina samples

Two studies were conducted to develop and examine internal consistencies and validate the Abbreviated Multidimensional Acculturation Scale. Study 1 participants were 156 Latino/Latina college students. Findings indicated good internal reliabilities for all 3 subscales. Adequate concurrent validity was established with length of residence in the United States. The scale also showed adequate convergent and discriminant validity. Study 2 participants were 90 Latino/Latina community members. The subscales were also reliable and showed adequate concurrent validity with length of residence in the United States. Convergent and discriminant validity were also adequate. Construct validity was further demonstrated through factorial analyses of the combined samples (N = 246). Three separate factors emerged: cultural identity, language competence, and cultural competence.     

Love and space in the nursing home

Nursing homes and other institutionsdesigned for persons with impairments are not,in fact, designed for persons with impairments.They are typically designed for theimpairments, not the persons, and therebybecome a part of the problem by reinforcingphysical and cultural manifestations of theimpairments. In the essay that follows, Idescribe an architectural design project inwhich students were asked to make changes to anexisting nursing home for the persons who livedthere. This requires not only becoming familiarwith the spaces, but with the personsthemselves and designing space to helparticulate their voices and being. This revised version was published online in June 2006 with corrections to the Cover Date.     

A Capuchin monkey (<Emphasis Type="Italic">Cebus apella</Emphasis>) recognizes when people do and do not know the location of food

In a previous study, Kuroshima and colleagues demonstrated that capuchin monkeys (Cebus apella) learned to discriminate between a "knower" who inspected a box for food, and a "guesser" who did not. The aim of the present study was to specify whether the subjects learned a simple conditional discrimination or a causal relationship that seeing leads to knowing. In experiment 1, we introduced five types of novel containers to two subjects. Each container was of different shape and color. The subjects gradually learned to reach toward the container the knower suggested. In experiment 2, we diversified the behavior of the knower and the guesser. In experiment 3, in order to eliminate the possibility of discrimination based on differences in the magnitude and the complexity of two trainers, we equated their behaviors. One subject adapted to the novel behaviors of the knower and the guesser, successfully discriminating the two trainers. Thus this monkey clearly learned to use the inspecting action of the knower and the non-inspecting action of the guesser as a discriminative cue to recognize the baited container. This result suggests that one capuchin monkey learned to recognize the relationship between seeing and knowing.