The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

Sentence processing: Evidence against the serial,independent stage assumption

The assumption that the processing stages involved in sentence comprehension are serially and independently executed was tested in two separate experiments using two new sentence types. One experiment was a sentence-picture verification task, the other was not. In Experiment I, subjects viewed sentences such as It's false that the dots are red and indicated, by pressing the appropriate response key, which of two colors would make the sentence true. In Experiment II, subjects verified sentences such as It isn't true that the dots aren't red against pictures of colored dots. On the strength of Sternberg's additive factor method, present findings challenge the validity of the serial, independent stage assumption, and results are alternatively discussed in terms of a capacity sharing model.This research was supported by PHS research grant MH 23401 to Sam Glucksberg, principal investigator.     

On the {↔, ∼} -reduct of the intuitionistic consequence operation

The intuitionistic consequence operation restricted to the language with (equivalence) and (negation) as the only connectives is axiomatized by means of a finite set of sequential rules of inference.To the memory of Professor Roman Suszko     

The development of discourse mapping processes: the on-line interpretation of anaphoric expressions

The present research focuses on how children integrate the antecedent of different kinds of anaphor into their on-going interpretation of an utterance, and on the kinds of cues they use to help them to do this. These issues were studied by examining the on-line processing of three types of anaphoric devices—repeated noun phrases, general terms and pronoun anaphors. The data showed that by the age of five, anaphoric mapping processes in general are well-mastered, although all age-groups (5, 7, 10 year olds and adults) found general term anaphors more difficult to interpret. The major developmental differences concerned the processing of anaphoric pronouns. For five year olds, pronouns were primarily interpreted as devices which maintained the thematic subject of the discourse, but when there was no thematic subject they relied primarily on pragmatic plausibility in their assignment of pronominal co-reference. As children get older, they are able to take advantage of the lexical properties of pronouns and all three sources of information—lexical, pragmatic inference and the thematic structure of the discourse—play contributory roles in the assignment of reference to a pronoun.     

Feedback interventions and driving speed: A parametric and comparative analysis

Five experiments were conducted to assess the effects of several variables on the efficacy of feedback in reducing driving speed. Experiment 1 systematically varied the criterion used to define speeding, and results showed that the use of a lenient criterion (20 km/hr over the speed limit), which allowed for the posting of high percentages of drivers not speeding, was more effective in reducing speeding than the use of a stringent criterion (10 km/hr over the speed limit). In Experiment 2 an analysis revealed that posting feedback reduced speeding on a limited access highway and the effects persisted to some degree up to 6 km. Experiments 3 and 4 compared the effectiveness of an unmanned parked police vehicle (Experiment 3) and a police air patrol speeding program (Experiment 4) with the feedback sign and determined whether the presence of either of these enforcement variables could potentiate the efficacy of the sign. The results of both experiments demonstrated that although the two enforcement programs initially produced larger effects than the feedback sign, the magnitude of their effect attenuated over time. Experiment 5 compared the effectiveness of a traditional enforcement program with a warning program which included handing out a flier providing feedback on the number and types of accidents occuring on the road during the past year. This experiment demonstrated that the warning program produced a marked reduction in speeding and the traditional enforcement program did not. Furthermore, the warning program and a feedback sign together produced an even greater reduction in speeding than either alone.     

Some theory and results for metrics for bounded response scales

In an earlier note, a new metric for bounded response scales (MBR) was introduced which resembles the city-block metric but is bounded above. It was suggested the MBR may be more appropriate than minkowski metrics for data obtained with bounded response scales. In this article, some formal properties of the MBR are investigated and it is shown that it is indeed a metric. Empirical predictions are then derived from the MBR and contrasted with those of a “monotonicity hypothesis,” which holds that dissimilarity judgements tend to be biased towards overestimation of larger distances, and with the predictions of the minkowski metrics, which imply additivity of collinear segments. Some empirical results are presented which contradict the monotonicity hypothesis and the minkowski metrics, and favor the MBR. Finally, the logic used to motivate the MBR is invoked to define a subadditive concatenation for bounded norms in the one-dimensional case, which may be useful in psychophysical work where the upper bounds are often real, rather than due to the response scale. This concatenation predicts understimation for doubling and overestimation for halving and middling tasks.     

Discrete dynamic choice: An extension of the choice models of thurstone and luce

The present paper deals with the extension of two well-known static discrete choice theories to the dynamic situation in which individuals make choices at several points in (continuous) time. A dynamic version of Luce's Axiom, “independence from irrelevant alternatives”, is proposed and some of its implications are derived. In the static case Yellott (J. Math. Psych. 1977, 15, 109–146) and others have demonstrated that an independent random utility model generated from the extreme value distribution exp(?e^?ax?b) becomes equivalent to Luce's Axiom. Yellott also introduced an axiom called “invariance under uniform expansions of the choice set”, and he proved that within the class of random utility models with independent identically distributed utilities (apart from a location shift) this axiom is equivalent to Luce's Axiom. These results are extended to the dynamic situation and it is shown that if the utility processes are expressed by so-called extremal processes the corresponding choice model is Markovian. A nonstationary generalization is proposed which is a substantial interest in applications where the parameters of the choice process are influenced by previous choice experience or by time-varying exogenous variables. In particular, it is demonstrated that the nonstationary model is Markovian if and only if the joint choice probabilities at two points in time have a particular form. Thus, the paper provides a rationale for applying a specific class of Markov models as the point of departure when modelling mobility processes that involve individual discrete decisions over time.     

Stimulus generalization and the peak shift with movement stimuli

Stimulus generalization is suggested as an alternative method for examination of the "novelty" problem in motor learning. These experiments demonstrated that stimulus generalization occurs using simple movements as stimuli. The phenomenon of the "peak shift" in post-discrimination generalization gradients was also examined. The first experiment demonstrated that a peak shift occurred using linear movements as stimuli and that the magnitude of the peak shift increased as the difference between the training stimuli decreased. The second experiment showed similar results when the stimuli consisted of a range of movements rather than single movement length. The final experiment provided evidence that perception of movement length is influenced by the magnitude of an immediately preceding movement. The relevance of these studies to current motor-learning theory is discussed.     

The effects of distributed training on retention of operant conditioning in human infants

Long-term retention of operant footkicking acquired in the mobile conjugate reinforcement paradigm was assessed as a function of the distribution of training time. In the first study, 3-month-old infants were trained for either one 18-min session or for two 9-min or three 6-min sessions separated by 24-hr intervals. All infants exhibited retention during a test administered immediately after training, but only those trained in a single session continued to perform the conditioned response during cued-recall tests 7 or 14 days later. Infants trained in three sessions showed no evidence of remembering the contingency even after a week. A warm-up decrement, seen in the day-to-day performance of infants in the distributed conditions, was eliminated in the second study by the interpolation of a nonreinforcement period at the outset of daily sessions. This procedure also enhanced long-term retention such that infants trained in three 6-min session now remembered the contingency for 14 days and did not differ from infants who had received a single 18-min session. Whether distributed training facilitates or impairs long-term retention appears to depend on the opportunity for infants to acquire a sufficient number (or kind) of effective retrieval cues during original learning.