Immediate as well as delayed post learning sleep but not wakefulness enhances declarative memory consolidation in children

While there is mounting evidence for the importance of sleep for declarative memory consolidation in adults, so far this issue has not been investigated in children despite considerable differences in sleep duration and sleep architecture between children and adults. Here, 27 children (aged between 9 and 12yr) were examined on two conditions: on the Sleep-Wake condition, subjects learned word pairs in the evening and delayed recall was tested first in the next morning after sleep and then again in the following evening after daytime wakefulness. On the Wake-Sleep condition, learning took place in the morning and delayed recall was tested in the evening of the same day and again in the next morning after sleep. In both conditions retention of declarative memory was significantly increased only after an interval of sleep that either followed immediately after learning (as in the Sleep-Wake condition) or that followed after daytime wakefulness (as in the Wake-Sleep condition), respectively. The results support the hypothesis that sleep plays an active role in declarative memory consolidation even if delayed and further show for the first time the importance of sleep for declarative memory consolidation during childhood.     

Developmental Changes In Switching Between Mental Task Sets: The Influence Of Verbal Labeling In Childhood

Age-related changes in the use of verbal processes for the efficient switching between tasks were investigated in 5-year-old children (N = 32, M age = 5.9 years) and 9-year-old children (N = 32, M age = 9.4 years). Task switching was assessed by means of a cued switching paradigm to examine two switching components: (a) to maintain and select and (b) to switch between task sets. The aim of this study is to determine (a) developmental changes in both switching components during childhood, (b) whether age-related changes in these components are influenced by verbalizations in terms of “thinking aloud” (Ericsson & Simon, 1993) during task performance, and (c) age changes in the content of the self-verbalizations. Results show an age-related impairment of the 5-year-old group on the level of task-set maintenance and selection. Children mainly verbalized the response labels. However, whereas 5-year-olds more often labeled their perceptions (Zelazo, 1999), 9-year-olds used language to maintain the currently relevant task set. Both age groups relied on the same verbal strategy facilitating task switching, supporting the view that language can be used to plan and guide actions (Luria, 1969).     

Cognitive and neural consequences of memory suppression in major depressive disorder

Negative biases in cognition have been documented consistently in major depressive disorder (MDD), including difficulties in the ability to control the processing of negative material. Although negative information-processing biases have been studied using both behavioral and neuroimaging paradigms, relatively little research has been conducted examining the difficulties of depressed persons with inhibiting the retrieval of negative information from long-term memory. In this study, we used the think/no-think paradigm and functional magnetic resonance imaging to assess the cognitive and neural consequences of memory suppression in individuals diagnosed with depression and in healthy controls. The participants showed typical behavioral forgetting effects, but contrary to our hypotheses, there were no differences between the depressed and nondepressed participants or between neutral and negative memories. Relative to controls, depressed individuals exhibited greater activity in right middle frontal gyrus during memory suppression, regardless of the valence of the suppressed stimuli, and differential activity in the amygdala and hippocampus during memory suppression involving negatively valenced stimuli. These findings indicate that depressed individuals are characterized by neural anomalies during the suppression of long-term memories, increasing our understanding of the brain bases of negative cognitive biases in MDD.     

Gravitational lensing and Hacking's extragalactic irreality

In Extragalactic Reality: The Case of Gravitational Lensing Hacking resumes the discussion of scientific realism from the last chapter of Representing and Intervening. Since the criterion of manipulability cannot be applied to astronomical objects, experimental entity realism seems to be restricted to terrestrial entities. In fact, Hacking explicitly argues against astronomical realism. The case at issue is the existence of gravitational lenses. In this paper, I question Hacking's chief witness for astronomical antirealism: the gravitational lens system “0957+ 561”. It will be shown that Hacking's argumentation is misleading. Discussing astronomical realism as theory realism, Hacking focuses on the question of how to infer the existence of gravitational lenses from the truth of gravitational lens theory. But neither the reconstruction of gravitational lensing in terms of inference to the best explanation (IBE) nor the argument of underdetermination are tenable under closer inspection. My thesis is that a realist account of gravitational lensing can be given by relying on observation, causal capacities and home truths.     

Methylphenidate slows reactions of children with attention deficit disorder during and after an error

A Sternberg memory search task was administered under placebo and methylphenidate to 42 children with cross-situational attention deficit disorder (ADD), 31 children with cross-situational ADD plus oppositional features, and 25 patients with marginal ADD. Overall, stimulant medication enhanced accuracy and speed. In addition, patients reacted faster on correct responses not preceded by an error than on errors (especially false alarms) or on correct responses following an error. The slowness during error reactions may reflect decreased confidence or confusion during stimulus classification. This uncertainty may also lead subjects to respond with greater caution, hence more slowly, on correct responses following errors. Notably, methylphenidate increased the slowing of reactions on error trials as well as on correct reactions following an error. Stimulant medication may augment subjects' persistence when they are uncertain or confused, thereby heightening caution and promoting accuracy on succeeding trials. Consistent with previous reports of the generality of enhancement of performance by stimulant medication, the impact of methylphenidate was comparable for the three subtypes of ADD studied.Jaine Strauss is at Macalester College.This research was supported by National Institute of Mental Health Grants MH32103 and MH38118. We thank Rachel Avery, Christine Carriuolo, Lawrence Ota, the late Helen Pollock, and the University of Rochester's Strong Memorial Hospital Pharmacy for their assistance.     

Cognitive inhibition in depression

Cognitive inhibition is a key mechanism in the regulation of emotion. There is emerging evidence that depression is characterized by deficits in the inhibition of mood-congruent material. These deficits could result in prolonged processing of negative, goal-irrelevant aspects of presented information thereby hindering recovery from negative mood and leading to the sustained negative affect that characterizes depressive episodes. Indeed, it has been suggested that deficits in cognitive inhibition lie at the heart of memory and attention biases in depression, and set the stage for ruminative responses to negative events and negative mood states. A ruminative response style results in a heightened vulnerability to experience episodes of major depression. Recent research has demonstrated that deficient inhibition of negative material is associated with heightened rumination. In this article, we review the depression literature with a focus on studies that investigate cognitive inhibition in depressed participants and in participants who report a history of major depressive episodes. In addition, we summarize neurobiological findings that indicate a strong relation between depression and deficits in inhibition and we take a closer look at the relation of inhibition, rumination and mood regulation.     

Testing problem-solving capacities: differences between individual testing and social group setting

Testing animals individually in problem-solving tasks limits distractions of the subjects during the test, so that they can fully concentrate on the problem. However, such individual performance may not indicate the problem-solving capacity that is commonly employed in the wild when individuals are faced with a novel problem in their social groups, where the presence of a conspecific influences an individual’s behaviour. To assess the validity of data gathered from parrots when tested individually, we compared the performance on patterned-string tasks among parrots tested singly and parrots tested in social context. We tested two captive groups of orange-winged amazons (Amazona amazonica) with several patterned-string tasks. Despite the differences in the testing environment (singly vs. social context), parrots from both groups performed similarly. However, we found that the willingness to participate in the tasks was significantly higher for the individuals tested in social context. The study provides further evidence for the crucial influence of social context on individual’s response to a challenging situation such as a problem-solving test.