Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits. Furthermore, several high-throughput screens have identified Gadd45b as a candidate plasticity-related gene. However, a direct demonstration of a link between Gadd45b and memory has not been established. The current studies first determined whether expression of the Gadd45 family of genes was affected by contextual fear conditioning. Gadd45b, and to a lesser extent Gadd45g, were up-regulated in the hippocampus following contextual fear conditioning, whereas Gadd45a was not. Next, Gadd45b knockout mice were tested for contextual and cued fear conditioning. Gadd45b knockout mice exhibited a significant deficit in long-term contextual fear conditioning; however, they displayed normal levels of short-term contextual fear conditioning. No differences between Gadd45b knockout and wild-type mice were observed in cued fear conditioning. Because cued fear conditioning is hippocampus independent, while contextual fear conditioning is hippocampus dependent, the current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage. Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders.     

Domestic dogs’ (Canis familiaris) choices in reference to agreement among human informants on location of food

When interacting with others, informants may offer conflicting information or information of varying accuracy. Recent research suggests that young children do not trust all informants equally and are selective in both whom they solicit for information and whose claims they support. We explored whether domestic dogs (Canis familiaris) are similarly sensitive to agreement among informants. To this end, we utilized a common human gesture, pointing, to which recent research suggests dogs are sensitive. We conducted two experiments in which an experimenter secretly hid food in one of two clear containers while the dog was distracted. Next, a small group moved to indicate the food's location using stationary points positioned above the containers. In Experiment 1, two experimenters moved to stand behind the non-baited container, while a third experimenter moved to stand behind the baited container. Then, all directed one static point at the container in front of them. Experiment 2 exactly resembled Experiment 1 with the exception that the single experimenter standing behind the baited container directed two static points at the container (one with each hand). Dogs chose the container indicated by the majority in Experiment 1 significantly more often than chance, but chose the container indicated by the minority in Experiment 2 significantly more often than chance. This suggests that the number of points, not the number of people, more strongly influenced dogs' choices.     

Xunzi on Moral Expertise

This paper is about two proposals endorsed by Xunzi. The first is that there is such a thing as a moral expert, whose moral advice we should adopt even when we cannot appreciate for ourselves the considerations in favor of it. The second is that certain political authorities should be treated as moral experts. I identify three fundamental questions about moral expertise that contemporary philosophy has yet to address in depth, explicate Xunzi??s answers to them, and then give an account of politically authorized moral expertise as Xunzi understands it. The three questions at the heart of this study are these: how should we distinguish between knowing the correct course of action on another??s authority and knowing it for oneself? What exactly are the underlying considerations that the expert grasps and the novice does not? Who are the experts and in what spheres of life can they legitimately claim expertise?     

Using PPT to account for randomness in perception

According to many theories of decision making, of which signal detection theory is the most prominent, randomness is the main factor responsible for imperfect performance. These theories imply that correcting for attenuation due to randomness should result in perfect scores as long as the participants use nonextreme decision criteria. On the basis of a recent advance termed potential performance theory (Trafimow & Rice, Psychological Review 115:447-462, 2008), we performed auditory and visual detection experiments and corrected the scores for attenuation. Most participants in both experiments tended to perform at a less-than-perfect level, even after their scores were corrected. The findings demonstrate that at least one systematic factor influences detection that is not included in signal detection theory.     

An Integration of Feminism into Experiential Psychotherapy

Abstract

Feminist therapy altered how marriage and family therapists conceptualized their clients’ realities and psychopathology. Upon an extensive search of the literature, there is a sparse amount of literature regarding the integration of feminist therapy with experiential therapy. The authors discuss feminist and experiential therapy models, propose a model of feminist-experiential therapy, and highlight the need and fit of these theories. A discussion on giving space to silenced voices, establishing an egalitarian relationship, expanding the definition of deviance, and exploring the importance of language will be done to aid the experiential therapist in their work and expand their client’s experience.     

Emotionally-focused therapy and treatment as usual comparison groups in decreasing depression: A clinical pilot study

Abstract

Decades of research have shown that depression can have deleterious effects on couple relationships. Emotionally-focused therapy (EFT; Johnson, 2004 Johnson, S. M. (2004). The practice of emotionally focused couple therapy: Creating connection. East Sussex, UK: Brunner-Routledge. [Google Scholar]) is an empirically validated form of couple therapy, which has shown effectiveness in reducing depressive symptoms in couples where the wife has depression. The aim of the current pilot study was to examine the extent to which EFT and the comparison treatment as usual (TAU) therapy group decrease depressive symptoms in distressed couples. Results show that both groups were effective in decreasing depressive symptoms, with EFT showing a clinically significant reduction. Clinical implications and future research are discussed.     

Expectancy bias mediates the link between social anxiety and memory bias for social evaluation

Social anxiety (SA) involves a multitude of cognitive symptoms related to fear of evaluation, including expectancy and memory biases. We examined whether memory biases are influenced by expectancy biases for social feedback in SA. We hypothesised that, faced with a socially evaluative event, people with higher SA would show a negative expectancy bias for future feedback. Furthermore, we predicted that memory bias for feedback in SA would be mediated by expectancy bias. Ninety-four undergraduate students (55 women, mean age = 19.76 years) underwent a two-visit task that measured expectations about (Visit 1) and memory of (Visit 2) feedback from unknown peers. Results showed that higher levels of SA were associated with negative expectancy bias. An indirect relationship was found between SA and memory bias that was mediated by expectancy bias. The results suggest that expectancy biases are in the causal path from SA to negative memory biases for social evaluation.