The relationship between underpredicted pain and escape

Escape and avoidance that are disproportional to the danger of the pertinent stimulus are important clinical problems that are often related to inaccurate (catastrophic) expectations. One possible source of such expectations is a prior, underestimated aversive experience. In the present experiment the hypotheses that underestimated pain leads to escape and that it leads to avoidance were tested. In order to control for the effect of the intensity of the pain stimulus, a control group that received 20 pain stimuli of high intensity was formed. Subjects in the experimental condition received 17 pain stimuli of low intensity and 3 of (unexpectedly) high intensity (experimentally induced underprediction). Underprediction of the high intensity stimulus was significantly related to escape, but not to avoidance. The results suggest that the way in which avoidance was operationalized accounts for this. The strong support of the hypothesized relationship between underpredicted pain and escape is an important finding, however.     

Medical expertise asa function of task difficulty

This paper is concerned with factors that disrupt the pattern of forward reasoning characteristic of experts with accurate performance. Two experiments are described. In the first, the performances of cardiologists, psychiatrists, and surgeons in diagnostic explanation of a clinical problem in cardiology were examined. In the second, the performances of cardiologists and endocrinologists in diagnostic explanation of clinical problems within and outside their domains of expertise were examined. The performances of researchers and practicing physicians are also compared. The results of Experiment 1 replicated earlier results regarding the relationship between forward reasoning and accurate diagnosis. There were no differences in recall as a function of expertise. Experts did not show any bias toward using specific knowledge from their own areas of expertise. The results of Experiment 2 showed that the breakdown of forward reasoning was related to the structure of the task. In particular, nonsalient cues induced some backward reasoning even in subjects with accurate diagnoses. Some differences were also found between the types of explanation used by researchers and practitioners. The practitioners referred more to clinical components in their explanations, whereas the researchers focused more on the biomedical components.     

Bilingual language processing after a lesion in the left thalamic and temporal regions. A case report with early childhood onset.

This case study concerns an 18-year-old bilingual girl who suffered a radiation lesion in the left (dominant) thalamic and temporal region when she was 4 years old. Language and memory assessment revealed deficits in auditory short-term memory, auditory word comprehension, nonword repetition, syntactic processing, word fluency, and confrontation naming tasks. Both languages (English and Dutch) were found to be affected in a similar manner, despite the fact that one language (English) was acquired before and the other (Dutch) after the period of lesion onset. Most of the deficits appear to be related to verbal (short-term) memory dysfunction. Several hypotheses of subcortical involvement in memory processes are discussed with reference to existing theories in this area.     

Transparent layer constancy

Perceived transparency was studied as a constancy problem. In the episcotister (E-) model of scission, luminances are partitioned into layer and background components; four luminances determine values of two layer parameters that specify constancy of a transparent layer on different backgrounds. The E-model was tested in an experiment in which 12 Ss matched 24 pairs of four-luminance patterns by adjusting two luminances of the comparison pattern. Both the standard and the comparison were perceived as a transparent layer on a checkerboard. The E-model predicts matches when layer values are identical in the two patterns. One parameter was constant, constraining the adjustment along the second dimension. Obtained values corresponded well with E-predictions. Alternative models based on local luminance or average contrast ratios accounted for less variability. Results indicate that transparency models should utilize luminance, not reflectance, as the independent variable.     

Effects of Level of Processing on Implicit and Explicit Memory in Depressed Mood

Recently, several studies have addressed the question of whether depression affects priming in implicit memory tasks. The main aim of this experiment was to assess the presence of a bias for negative information in explicit memory (free recall) and implicit memory (word-stem completion) tasks among subclinically depressed subjects compared to nondepressed subjects, using the typical levels of processing manipulation. The results of this study show the existence of a mood-congruent memory bias for both implicit and explicit memory in depressed subjects. The theoretical implications of these findings for implicit and explicit memory biases associated with depressed mood are discussed.     

TheP system: A scheme for organizing Pavlovian procedures

The present paper introduces theP system as a scheme for organizing Pavlovian procedures in an orderly and comprehensive manner. The system is defined by three temporal variables and three restrictions on their possible values. It can be used to define all standard temporal variables—namely, stimulus duration, interstimulus interval, trace interval, and intertrial interval—as well as variables C and T of scalar expectancy theory. The system also permits the definition of new independent variables through combinations of the basic temporal parameters. We exemplify this possibility by defining two ratios of temporal intervals. These ratios lead to a space where traditional Pavlovian arrangements (viz., simultaneous, forward-trace, forward-delay, backward) become points on a continuum, and optimal conditions across different experimental preparations become equivalent. Finally, the system can be used to define contingency variables such asp(US/CS),p(US/～CS), and the phi coefficient (φ). In this manner, an organization of different kinds of Pavlovian procedures is achieved on the basis of a single parametric scheme. Such an organization facilitates establishing procedural and theoretical relationships between temporal and contingency variables. The paper concludes with a discussion of certain limitations of the system and other related issues     

Mini-Review; Stress Genes: An Introductory Overview

Molecular sequence data, made available in the last 15 years or so, have led to the classification of living cells into three phylogenetic domains: Bacteria, Archaea, and Eucarya. All the organisms that have been tested belonging to either domain were capable of mounting a stress response with essentially the same characteristics, regardless of the stressor. The protagonists in the cell's stress response are the stress genes and their protein products. Some of the latter are molecular chaperones. Under physiological conditions, these chaperones aid other cellular proteins to fold properly and achieve a native -functional- configuration, and to translocate from the place of synthesis to the cell's locale in which they will operate. In a stressed cell, the stress proteins that are chaperones protect other molecules from denaturation and help those partially damaged to regain a functional configuration. Thus, cell death is avoided and recovery is enhanced. The study of stress genes and proteins has progressed considerably in organisms belonging to the domains Bacteria and Eucarya. Less is known about the archaeal stress genes. Here, research with an organism from the Archaea is discussed, focusing on the stress genes of the hsp70 (dnaK) locus. Future perspectives for basic and applied research within the health sciences and biotechnology industries are presented.