LTP induction modifies functional relationship among hippocampal neurons

To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered 'functional connectivity,' as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity.     

The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice

Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-maze testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.     

Morphological changes in dendritic spines of Purkinje cells associated with motor learning

Experience-dependent changes of spine structure and number may contribute to long-term memory storage. Although several studies demonstrated structural spine plasticity following associative learning, there is limited evidence associating motor learning with alteration of spine morphology. Here, we investigated this issue in the cerebellar Purkinje cells using high voltage electron microscopy (HVEM). Adult rats were trained in an obstacle course, demanding significant motor coordination to complete. Control animals either traversed an obstacle-free runway or remained sedentary. Quantitative analysis of spine morphology showed that the density and length of dendritic spines along the distal dendrites of Purkinje cells were significantly increased in the rats that learned complex motor skills compared to active or inactive controls. Classification of spines into shape categories indicated that the increased spine density and length after motor learning was mainly attributable to an increase in thin spines. These findings suggest that motor learning induces structural spine plasticity in the cerebellar Purkinje neurons, which may play a crucial role in acquiring complex motor skills.     

图片和汉字的激活水平及知觉干扰效应的比较

研究使用8个残缺水平下的图片及其中文名（汉字双字词）为实验材料．试图比较图片与汉字双字词识别激活水平的差异,接着比较二者产生知觉于扰效应的条件,并把二者产生知觉于扰的条件与英文单词产生知觉于扰的条件进行比较。实验一结果发现,在材料较清晰的条件下,汉字双字词的命名成绩高于图片,表明汉字双字词的激活水平不比图片低,但在材料很残缺的条件下,汉字双字词的命名成绩低于图片。实验二发现双字词和图片在没有事先学习情况下都产生知觉干扰效应,已有研究表明单个汉字无需事先学习也可以产生干扰效应,而英文单词需要事先学习。因此,图片和汉字的干扰效应与英文单词的差别跟图片、汉字的激活水平比英文单词高有关。     

在亲／反社会情境下儿童对说谎的理解及其道德评价的研究

本研究比较了幼儿及小学儿童在亲社会与反社会情境下对说谎/说真话的理解及幼儿对其所作的道德评价上的年龄差异.结果表明自4岁开始儿童能够明确地理解说谎/说真话,并作出相应的道德判断.但3岁幼儿无论是对说谎/说真话概念的判断,还是道德评价,不能对行为与言语作明确的区别.习俗性特征对说谎概念判断的影响始于9岁.     

来自基层医生的呼吁：重视社区医疗—《行医日记》选载

《行医日记》用行医实践说明了社区医疗的作用、地位、服务方式、服务内容以及社区医疗的诸多困难,社区医疗应该有其特定的社会地位和学术地位,以下几篇内容是根据日常所做、所想、所感而作的总结。对基层医疗的社区服务性质应该有个全新的认识。     

情绪调节策略对推理的影响

研究使用两种推理题作为实验材料.比较了负性情绪诱发状态下情绪调节策略使用与否以及不同情绪调节策略对推理的影响.结果发现,认知重评组的成绩好于表达抑制组和无调节组,存在显著差异;表达抑制组与无调节组之间不存在差异.此外,在表达抑制组上,男生的图形推理成绩好于女生,存在显著的性别差异.因此,个体不同推理任务的成绩与是否使用调节策略、使用什么策略及性别有关.     

影响学生学业求助的因素及其有效策略探析

越来越多的学者认为,学业求助是一种重要的自我调控学习策略,对学生的学习具有重要的意义。本文总结了与学业求助有关的影响因素,包括成就目标、自我效能、班级环境和任务难度,并在此基础上探讨了激发学生有效求助的学习策略。     

An Integrative Review of School-Based Mental Health Interventions for Elementary Students: Implications for Occupational Therapy

Occupational therapy for children and youth experiencing mental health conditions is often overlooked in current school-based services, as the traditional role within the system is often limited to physical health issues. The purpose of this integrative review is to investigate current psychosocial interventions within school settings to understand the effects of services provided and to determine potential roles for school-based occupational therapists. The findings of this review support occupational therapists in facilitating interventions that target mental health in school settings. Psychotherapy presented the strongest evidence for reducing psychosocial symptoms in school settings.