Treatment of acute mania with ambient air anionization: variants of climactic heat stress and serotonin syndrome

High concentrations of ambient anions (O2-) were used to augment treatment for 20 acutely manic male patients. Anions were produced by an anion generator in a sealed room. A double-blind crossover design was used, and responses were evaluated with the Brief Psychiatric Rating Scale by 2 blinded raters. This produced a significant antimanic effect: total rating scores declined with anion treatment. Presham and postsham total scores for these 5 were 31.3 and 31.6, respectively. Pretreatment and posttreatment total scores were 31.6 and 26.3, respectively. Previous research indicates a role for serotonin in producing this antimanic effect.     

An analysis of calendar performance in two autistic calendar savants

We acquired large data sets of calendar performance from two autistic calendar savants, DG and RN. An analysis of their errors and reaction times revealed that (1) both individuals had knowledge of calendar information from a limited range of years; (2) there was no evidence for the use of memorized anchor dates that could, by virtue of counting away from the anchors, allow correct responses to questions about other dates; and (3) the two individuals differed in their calendar knowledge, as well as in their ability to perform secondary tasks in which calendar knowledge was assessed indirectly. In view of the fact that there are only 14 possible annual calendars, we suggest that both savants worked by memorizing these 14 possible calendar arrangements.     

Adaptation to sensory-motor temporal misalignment: instrumental or perceptual learning?

Sensory-motor delays vary over the course of development and under different environmental conditions. Previous research has shown that humans can compensate for the resulting temporal misalignment while performing sensory-motor tasks (e.g., Cunningham, Billock, & Tsou, 2001a), but remains silent on the question of whether perceptual learning-similar to that involved in adaptation to spatial misalignment (e.g., Redding & Wallace, 1993) and in adaptation to purely intersensory misalignment (e.g., Fujisaki, Shimojo, Kashino, & Nishida, 2004)-is also involved in this adaptive response. Following an attempted replication of Cunningham et al.'s (2001a) study in a preliminary experiment, we present in this paper two experiments that demonstrate that after-effects of adaptation to temporal misalignment do not spontaneously decay. The literature on adaptation to spatial misalignment suggests that, while instrumental learning spontaneously decays in the absence of reinforcement, perceptual learning persists. Therefore our results are consistent with adaptation being effected through perceptual learning.     

AGGRESSION AS POSITIVE REINFORCEMENT IN MICE UNDER VARIOUS RATIO‐ AND TIME‐BASED REINFORCEMENT SCHEDULES

There is evidence suggesting aggression may be a positive reinforcer in many species. However, only a few studies have examined the characteristics of aggression as a positive reinforcer in mice. Four types of reinforcement schedules were examined in the current experiment using male Swiss CFW albino mice in a resident—intruder model of aggression as a positive reinforcer. A nose poke response on an operant conditioning panel was reinforced under fixed‐ratio (FR 8), fixed‐interval (FI 5‐min), progressive ratio (PR 2), or differential reinforcement of low rate behavior reinforcement schedules (DRL 40‐s and DRL 80‐s). In the FR conditions, nose pokes were maintained by aggression and extinguished when the aggression contingency was removed. There were long postreinforcement pauses followed by bursts of responses with short interresponse times (IRTs). In the FI conditions, nose pokes were maintained by aggression, occurred more frequently as the interval elapsed, and extinguished when the contingency was removed. In the PR conditions, nose pokes were maintained by aggression, postreinforcement pauses increased as the ratio requirement increased, and responding was extinguished when the aggression contingency was removed. In the DRL conditions, the nose poke rate decreased, while the proportional distributions of IRTs and postreinforcement pauses shifted toward longer durations as the DRL interval increased. However, most responses occurred before the minimum IRT interval elapsed, suggesting weak temporal control of behavior. Overall, the findings suggest aggression can be a positive reinforcer for nose poke responses in mice on ratio‐ and time‐based reinforcement schedules.     

Relationship between manual preferences for object manipulation and pointing gestures in infants and toddlers

The aim of this study was to measure the pattern of hand preferences for pointing gestures as a function of object‐manipulation handedness in 123 infants and toddlers (10–40 months). The results showed that not only right‐handers but also left‐handers and ambidextrous participants tended to use their right hand for pointing. There was a significant correlation between manual preferences and pointing lateralization. Further analyses showed that the correlation between these two indexes was at its strongest during two key phases of language development (i.e. vocabulary spurt and syntax improvement) and weakened to become nonsignificant in the interim. These findings support the view that humans have a specialized area for communicative gestures and language in the left cerebral hemisphere that may be independent of the system controlling the purely motor functions of hand use.     

Parafoveal-on-foveal interactions in word recognition

An experiment is reported in which participants read sequences of five words, looking for items describing articles of clothing. The third and fourth words in critical sequences were defined as "foveal" and "parafoveal" words, respectively. The length and frequency of foveal words and the length, frequency, and initial-letter constraint of parafoveal words were manipulated. Gaze and refixation rate on the foveal word were measured as a function of properties of the parafoveal word. The results show that measured gaze on a given foveal word is systematically modulated by properties of an unfixated parafoveal word. It is suggested that apparent inconsistencies in previous studies of parafoveal-on-foveal effects relate to a failure to control for foveal word length and hence the visibility of parafoveal words. A serial-sequential attention-switching model of eye movement control cannot account for the pattern of obtained effects. The data are also incompatible with various forms of parallel-processing model. They are best accounted for by postulating a process-monitoring mechanism, sensitive to the simultaneous rate of acquisition of information from foveal and parafoveal sources.     

Reducing the serious behavior problems of people with developmental disabilities living in the community

Trends and issues regarding the community-based support of people with developmental disabilities who exhibit severe behavior problems are discussed. Living in the community provides a unique framework within which behavior change programs are developed, implemented, and monitored. Support models for people with challenging behavior need to: (a) program for diversity across people, settings, and activities; (b) plan for high levels of integration in community settings among typical community members; and (c) meet guidelines regarding restrictions in intervention typologies. Increasingly, behavior analysts are conducting analog and in vivo assessments prior to intervening in order to develop an understanding of why behavior problems are occurring. Along with the increase in assessing the functions of behavior, is a greater attention to the contexts in which interventions are applied. The rearranging of contexts, communication training, choice-making, matching people's competence to their settings, the use of novelty, and proactive programing reflect these concerns.