Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processes

Between-study comparisons of benzodiazepine and anticholinergic drugs on working memory suggest that anticholinergics may produce greater impairment in maintenance processes, whereas benzodiazepines may produce greater impairment in manipulation processes. This study directly compared acute effects of the benzodiazepine lorazepam (1.0 and 2.0 mg/70 kg, orally administered) and the anticholinergic scopolamine (0.25 and 0.50 mg/ 70 kg, subcutaneously administered) on working memory maintenance (storage and rehearsal) and manipulation processes in a placebo-controlled, double-dummy, double-blind, crossover design in 20 healthy volunteers. Using a modified Sternberg paradigm, storage, rehearsal, and manipulation processes were parametrically manipulated by varying memory load, delay between stimulus presentation and test, and number of operations performed on the letter strings, respectively, while controlling for drug effects on nonmemory processes. As predicted, the results suggested greater impairment in maintenance processes (rehearsal) with scopolamine than with lorazepam and greater impairment in manipulation processes with lorazepam than with scopolamine. In addition, the results suggested greater overall slowing of working memory processes with lorazepam.     

Religious Identity and Cultural Diversity: Exploring the Relationships Between Religious Identity,Sexism, Homophobia,and Multicultural Competence

In this article, the authors present the results from a national study investigating the relationships between religious identity, sexism, homophobia, and multicultural competence. Participants were 111 randomly sampled counseling professionals and graduate students. The results indicated a relationship between religious identity and various aspects of valuing cultural diversity, including sexism, homophobia, and multicultural competence. Implications of the role of religion and religious identity in counseling are discussed, and suggestions for future research are provided.     

Can medicalization be good? Situating medicalization within bioethics

Medicalization has been a process articulated primarily by social scientists, historians, and cultural critics. Comparatively little is written about the role of bioethics in appraising medicalization as a social process. The authors consider what medicalization means, its definition, functions, and criteria for assessment. A series of brief case sketches illustrate how bioethics can contribute to the analysis and public policy discussion of medicalization.     

Youth Departing from Residential Care: A Gender Comparison

Although females represent almost half of all youth involved in residential care in the US, very little is known about this population. In order to examine differences in characteristics of male (n = 308) and female (n = 180) youth departing from residential care, data were collected on 488 youth from a large residential treatment facility in the Midwest. Gender differences were assessed on 16 variables measured at the time of departure across family, education, behavior, and departure domains. Overall, male and female youth departing from residential care were very similar for measures collected at the time of departure. Only three variables (GPA at departure, number of school referrals during the previous 8 weeks, and planned departure) were found to be significantly different between males and females. Implications for future research and the provision of aftercare services are discussed.     

Parents’ Autobiographical Narratives: Setting Events for Their Contemplation of Mindful Changes

The ability to tell a coherent and rich story about one’s personal life is an important marker of an individual’s capacity and willingness to contemplate personal change. We review research on correlations between the coherence of parents’ narrative accounts of life experiences and their responsiveness during interactions with their children. Based on this review, we explore ideas about the nature of narrative coherence, how parents might be taught to improve this structural feature when telling their stories, and why a well constructed story might enhance the parents’ objective study of the here and now. We discuss how the effects of narrative restructuring may enable parents to be more cognitively mindful of their interactions with their children. We present our speculations in the spirit of promoting discussion of new clinical strategies for parents and new research strategies aimed at experimental analyses of observed connections between parent narratives and their willingness to contemplate personal change.     

The narrow fellow in the grass: human infants associate snakes and fear

Why are snakes such a common target of fear? One current view is that snake fear is one of several innate fears that emerge spontaneously. Another is that humans have an evolved predisposition to learn to fear snakes. In the first study reported here, 9‐ to 10‐month‐old infants showed no differential spontaneous reaction to films of snakes versus other animals. In the second study, 7‐ to 18‐month‐old infants associated snakes with fear: As predicted, they looked longer at films of snakes while listening to a frightened human voice than while listening to a happy voice. In the third study, infants did not look differentially to still photos of snakes and other animals, indicating that movement is crucial to infants’ association of snakes with fear. These results offer support for the view that humans have a natural tendency to selectively associate snakes with fear.     

Tactile Enumeration and Embodied Numerosity Among the Deaf

Representations of the fingers are embodied in our cognition and influence performance in enumeration tasks. Among deaf signers, the fingers also serve as a tool for communication in sign language. Previous studies in normal hearing (NH) participants showed effects of embodiment (i.e., embodied numerosity) on tactile enumeration using the fingers of one hand. In this research, we examined the influence of extensive visuo-manual use on tactile enumeration among the deaf. We carried out four enumeration task experiments, using 1–5 stimuli, on a profoundly deaf group (n = 16) and a matching NH group (n = 15): (a) tactile enumeration using one hand, (b) tactile enumeration using two hands, (c) visual enumeration of finger signs, and (d) visual enumeration of dots. In the tactile tasks, we found salient embodied effects in the deaf group compared to the NH group. In the visual enumeration of finger signs task, we controlled the meanings of the stimuli presentation type (e.g., finger-counting habit, fingerspelled letters, both or neither). Interestingly, when comparing fingerspelled letters to neutrals (i.e., not letters or numerical finger-counting signs), an inhibition pattern was observed among the deaf. The findings uncover the influence of rich visuo-manual experiences and language on embodied representations. In addition, we propose that these influences can partially account for the lag in mathematical competencies in the deaf compared to NH peers. Lastly, we further discuss how our findings support a contemporary model for mental numerical representations and finger-counting habits.     

Cerebellar Contributions to Proactive and Reactive Control in the Stop Signal Task: A Systematic Review and Meta-Analysis of Functional Magnetic Resonance Imaging Studies

Neuropsychology Review - The cerebellum facilitates and modulates cognitive functions using forward and inverse internal models to predict and control behavior, respectively. Despite neuroimaging...