Pharmacological treatment effects on eye movement control

The increasing use of eye movement paradigms to assess the functional integrity of brain systems involved in sensorimotor and cognitive processing in clinical disorders requires greater attention to effects of pharmacological treatments on these systems. This is needed to better differentiate disease and medication effects in clinical samples, to learn about neurochemical systems relevant for identified disturbances, and to facilitate identification of oculomotor biomarkers of pharmacological effects. In this review, studies of pharmacologic treatment effects on eye movements in healthy individuals are summarized and the sensitivity of eye movements to a variety of pharmacological manipulations is established. Primary findings from these studies of healthy individuals involving mainly acute effects indicate that: (i) the most consistent finding across several classes of drugs, including benzodiazepines, first- and second- generation antipsychotics, anticholinergic agents, and anticonvulsant/mood stabilizing medications is a decrease in saccade and smooth pursuit velocity (or increase in saccades during pursuit); (ii) these oculomotor effects largely reflect the general sedating effects of these medications on central nervous system functioning and are often dose-dependent; (iii) in many cases changes in oculomotor functioning are more sensitive indicators of pharmacological effects than other measures; and (iv) other agents, including the antidepressant class of serotonergic reuptake inhibitors, direct serotonergic agonists, and stimulants including amphetamine and nicotine, do not appear to adversely impact oculomotor functions in healthy individuals and may well enhance aspects of saccade and pursuit performance. Pharmacological treatment effects on eye movements across several clinical disorders including schizophrenia, affective disorders, attention deficit hyperactivity disorder, Parkinson’s disease, and Huntington’s disease are also reviewed. While greater recognition and investigation into pharmacological treatment effects in these disorders is needed, both beneficial and adverse drug effects are identified. This raises the important caveat for oculomotor studies of neuropsychiatric disorders that performance differences from healthy individuals cannot be attributed to illness effects alone. In final sections of this review, studies are presented that illustrate the utility of eye movements for use as potential biomarkers in pharmacodynamic and pharmacogenetic studies. While more systematic studies are needed, we conclude that eye movement measurements hold significant promise as tools to investigate treatment effects on cognitive and sensorimotor processes in clinical populations and that their use may be helpful in speeding the drug development pathway for drugs targeting specific neural systems and in individualizing pharmacological treatments.     

The role of global top-down factors in local eye-movement control in reading

Although the development of the field of reading has been impressive, there are a number of issues that still require much more attention. One of these concerns the variability of skilled reading within the individual. This paper explores the topic in three ways: (1) it quantifies the extent to which, two factors, the specific reading task (comprehension vs. word verification) and the format of reading material (sentence vs. passage) influence the temporal aspects of reading as expressed in word-viewing durations; (2) it examines whether they also affect visuomotor aspects of eye-movement control; and (3) determine whether they can modulate local lexical processing. The results reveal reading as a dynamic, interactive process involving semi-autonomous modules, with top-down influences clearly evident in the eye-movement record.     

A Work-Life Identity Model of Well-Being: Towards a Research Agenda Linking Quality-of-Work-Life (QWL) Programs with Quality of Life (QOL)

QWL is conceptualized in terms of the interface between employee role identities and work resources. QWL programs serve to enhance QOL by (1) providing appropriate work resources to meet the expectations of employee role identities, (2) reducing role conflict in work and non-work life, (3) enhancing multiple role identities, (4) reducing role demands, (5) reducing stress related to work and non-work role identities, and (6) increasing the value of the role identity. We describe a variety of QWL programs related to work life (decentralized organization structures, teamwork, parallel structures, ethical corporate mission and culture, the organization work schedule, etc.) and non-work life (work at home, flextime, compressed work week, part-time work arrangements, job sharing, etc.) and show how they serve to enhance QOL using the language of work-life identity. Doing so helps develop a research agenda based on the work-life identify model.     

University psychology clinics in Australia: Their place in professional training

Abstract: There is universal recognition of the need for developmentally appropriate supervised clinical experience in professional psychology training. University clinics were established to provide a bridging function for postgraduate clinical psychology students, assisting the integration of psychological theory and research into real‐world clinical applications and professional identity development. The aim of training in university clinics is to provide opportunities for clinical practice and high‐quality supervision to monitor and shape clinical skills. The experiences gained in external practicum settings complement this initial training but cannot replace it. The recent introduction of Medicare rebates for psychology services has threatened the survival of university clinics because low‐cost psychological treatment is now available from experienced practitioners. This paper provides data on Australian university clinics collected before the introduction of Medicare. Concerted efforts are needed to protect university clinics in order to maintain standards required for accreditation of clinical psychology training programs. The potential impact of the loss of university training clinics is discussed and strategies to ensure their survival are suggested.     

The effects of attributions of intent and apology on forgiveness: When saying sorry may not help the story

Despite the oft-cited positive effects of an apology on forgiveness, forgiveness does not always follow. In three studies we tested the ironic notion that, following an interpersonal transgression, an apology following an attribution of intent might further hinder, rather than benefit, the forgiveness process. The findings of three studies were systematically replicated and supported our primary prediction that, following attributions of intent, saying sorry does not always lead to forgiveness. When offenders intentionally committed a transgression, forgiveness was less likely following an apology. However, when offenses were unintentional, forgiveness was more likely following an apology. We also showed that these effects were explained by participants’ impression of the transgressor.     

Detecting the snake in the grass: attention to fear-relevant stimuli by adults and young children

Snakes are among the most common targets of fears and phobias. In visual detection tasks, adults detect their presence more rapidly than the presence of other kinds of visual stimuli. We report evidence that very young children share this attentional bias. In three experiments, preschool children and adults were asked to find a single target picture among an array of eight distractors. Both the children and the adults detected snakes more rapidly than three types of nonthreatening stimuli (flowers, frogs, and caterpillars). These results provide the first evidence of enhanced visual detection of evolutionarily relevant threat stimuli in young children.     

Formal distinctiveness of high- and low-imageability nouns: analyses and theoretical implications

Words associated with perceptually salient, highly imageable concepts are learned earlier in life, more accurately recalled, and more rapidly named than abstract words (R. W. Brown, 1976; Walker & Hulme, 1999). Theories accounting for this concreteness effect have focused exclusively on semantic properties of word referents. A novel possibility is that word structure may also contribute to the effect. We report a corpus-based analysis of the phonological and morphological structures of a large set of nouns with imageability ratings (N = 2,023). High- and low-imageability nouns differed by length, etymology, prosody, affixation, phonological neighborhood density, and rates of consonant clustering. On average, nouns denoting abstract concepts were longer, more derivationally complex, and emerged in English from a different distribution of languages than did concrete nouns. We address implications for interactivity of word form and meaning as pertain to theories of word concreteness, lexical acquisition, and word processing.     

Trait Stability and Continuity in Childhood: Relating Sociability and Hostility to the Five-Factor Model of Personality

We investigated the continuity of personality constructs in the Oregon Youth Substance Use Project, a cohort-sequential study encompassing development from early childhood to adolescence with five annual or biennial assessments. Sociability and Hostility, assessed by teachers' ratings of children's behaviors at each assessment, were related to the traits comprising the Five-Factor model assessed by teachers' ratings at the fifth assessment. Confirmatory factor analysis demonstrated that Sociability and Hostility were reliably measured at each assessment, and these constructs were relatively stable over time (mean rank-order stability coefficients over intervals of 1-5 years were .50 and .43, respectively). Sociability was most strongly associated (positively) with Extraversion, and Hostility was most strongly associated (negatively) with Conscientiousness and Emotional Stability. No differences were found for younger versus older children. Implications for measuring childhood personality traits using teachers' reports of early childhood behavior are discussed.