Emerging therapeutics for Alzheimer's disease: an avenue of hope

Emerging therapies for Alzheimer's disease offer hope to patients and their caregivers. Future treatments will probably include combination approaches with agents that modify amyloid processing, deposition, and clearance. One example, the AD vaccine, reduced amyloid burden and changed behavior in animal models of AD, but the human trial was halted when several subjects developed brain inflammation. Anti-inflammatory agents have epidemiologic support, but clinical trials have been disappointing, possibly related to inadequate study with anti-inflammatory agents that modify amyloid processing. Agents that target known cardiovascular risk factors, such as hypercholesterolemia, hypertension, and insulin resistance, have epidemiologic, preclinical, and clinical evidence to warrant further investigation. Heavy metal chelators, antioxidants, neurotrophic factors, glutaminergic modulators, and agents that modify hyperphosphorylation of Tau are other approaches in research and development.     

Happy affect and smiling: is their relation moderated by interpersonal power?

Three studies examined the hypothesis that the relation between self-rated happy affect and overall smiling during dyadic interactions is moderated by one's relative power. In all 3 studies, interpersonal power was experimentally manipulated, and smiling and self-reported happy affect were measured during and after the interaction, respectively. Happy affect was positively correlated with overall smiling for both low-power and high-power participants. Moreover, the correlations for both low- and high-power participants were comparable to those found when power roles were not unequal or made salient, based on analysis of the present studies as well as comparison with the previously published literature. Happy affect and overall smiling had a positive relation that was not moderated by interpersonal power.     

Embodiment: An Introduction

Theoretical Medicine and Bioethics -     

Can the Media Create Public Opinion? A Social-Identity Approach

The media remains a powerful presence in U.S. culture. It gives people news of world and local events, it entertains, and it may even function as a companion to children. Because it functions as a window to the outside world, what appears across its landscape actually may become people's reality. Thus, the potential for distorting their view of that world is high if the picture provided is unrepresentative of actual events. For example, the prevalence of violent acts on television has been linked to increased aggression and escalating impressions of a dangerous world, and the overrepresentation of youth and beauty may be a causal factor of eating disorders. In this article, we explore the possibility that the media may also serve as a powerful creator of the very public opinions it seeks to reflect in its news. Subtle nonverbal cues of newscasters have been shown to influence voting behavior, and the media's overrepresentation of the proportion of blacks in poverty may decrease whites' support of welfare. By portraying a world in which people's opinions are based on their ethnic or demographic group membership, the media may also subtly but powerfully create the very opinions they seek to reflect.     

Theoretical Medicine and Bioethics Index to Volume 20

Volume Contents

heoretical Medicine and Bioethics Index to Volume 20     

Images of God and the imaginary in the face of loss: a quantitative research on Vietnamese immigrants living in Canada

ABSTRACT

This study examines the relationships between images of God, the imaginary and experiences of loss among Vietnamese immigrants living in Canada. One hundred twenty-nine participants completed four sets of questionnaires: a demographic questionnaire, a Questionnaire on God Image, the Brief Symptom Inventory, the Davidson Trauma Scale. In the second phase, 32 participants were administered the AT.9 test (an archetypal test with nine elements). In this test, participants are asked to draw, using nine symbolic elements, and then write a story based on their drawing. Results showed that a positive perception of God negatively correlated with somatisation, anxiety and hostility, whereas negative God image was significantly related to high levels of emotional distress. Results also showed that the synthetic categories of the imaginary were associated with a positive perception of God; and were negatively associated with somatisation, intrusion and hyper-vigilance. Further discussions on the main findings will address cultural implications in the fields of Mental Health, Religion and Culture.     

Adaptation and vulnerability in high-risk adolescents: An examination of environmental mediators

The relationship of characteristics of the social environment to the adaptation of adolescents from high-risk predisposing environments was examined. Specifically, the degree to which adolescents' perceptions of various dimensions of their family and school environment as well as sources of social support related to differential levels of personal well-being and academic adjustment was explored. Multiple regression analyses revealed differences in the salience of the dimensions of the social environment as a function of the particular sphere of functioning under consideration. Implications of the findings for developing a model for understanding the relative vulnerability of individuals at risk as well as of the design of preventive interventions are discussed.     

Book reviews

Weiskrantz, L. (1986). Blindsight: A case study and implications. Oxford University Press. Pp. 187. ISBN 0-19-852129-4. £19.50.

Humphreys, G. W. & Riddoch, M. J. (1987). to see but not to see: A case study of visual agnosia. Hove and London: Lawrence Erlbaum Associates Ltd. Pp. 124. ISBN 0-83677-064-9. £12.95.

Downing, J. A. (1988). Advances in psychology: Cognitive psychology and reading in the USSR. Amsterdam: North Holland; Elsevier Science Publishers. Pp. 471. ISBN 0-444-70374-8. $108.00.

John Beech & Ann Colley (Eds.) (1987). Cognitive approaches to reading. Chichester: John Wiley. Pp. xii + 315.

James Wertsch (Ed.) (1985). Culture, communication and cognition: Vygotskian perspectives. Cambridge: Cambridge University Press. Pp. 379. ISBN 0-521-25214-8. £27.50 (Hardback).

Fodor, J. A. (1987). Psychosemantics: The problem of meaning in the philosophy of mind. Cambridge, MA: M.I.T. Press. Pp. xiii, 1-171. ISBN 0-262-06106-6.

Richardson, K. (1988). Understanding Psychology. Milton Keynes: The Open University Press. Pp. 114. ISBN 0-335-09842-8. Paperback £7.95.

Stanovich, Keith E. (Ed.) (1988). Children's reading and the development of phonological awareness. Detroit: Wayne State University Press. Pp. 177. ISBN 0-8143-1909-2. $20.00.

Allport, A., MacKay, D.G., Prinz, W., & Scheerer, E. (Eds.), (1987). Language perception and production: Relationships between listening, speaking, reading, and writing. London: Academic Press. Pp. xiii + 497. ISBN 0-12-052750-2. £32.00

Light, L. L. & Burke, D. M. (eds.) (1988). Language, Memory and Aging. Cambridge: Cambridge University Press. Pp. 280. ISBN-0-521-32942-6. £27.50

Friedman, S.L., Scholnick, E.F., and Cocking, R. R. (1987). Bleuprints for thinking: The role of planing in cognitive development. Cambridge: Cambridge University Press. Pp. xv + 559. ISBN 0-521-25605-4. £40.00.