Acoustically evoked brain stem potential in Wilson disease

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.     

Retinal locus and the letter-span error function

The effect of retinal locus on the letter-span error function was investigated by requiring Ss to fixate at the left, middle, or right of lines of letters presented for 100 msec. Stimulus presentations consisted of lines of eight letters presented across the visual field, and lines of four letters presented alternately in the left and right visual hemifields. Locus of fixation and relative letter position were found to be significantly related to whether or not a letter was correctly localized. A significant interaction between locus of fixation and letter position was observed.     

Generalization gradients and stimulus control in delayed matching-to-sample

Neurological patients were subjects in delayed visual matching-to-sample. The sample and choice stimuli were ellipses of varying size. By measuring the difference in size between the sample on a given trial and the ellipse the subject chose on that trial, gradients of differences between samples and choice stimuli could be plotted. These difference gradients broadened with increasing delays. Sharp gradients were controlled by the samples. Flat gradients were controlled by features of the choice display, independently of the samples. Intermediate gradients reflected combined control by the samples and by the choice displays.     

Several methods for teaching serial position sequences to monkeys

Three keys were available for monkeys to press. The objective was to teach the animals to press the keys in sequences up to 10 members in length. With fading procedures, a light that cued the correct key at a given serial member of the sequence faded out slightly each time the animal selected it, and became slightly brighter after the animal made an error at that sequence member. The correct keys were faded out, starting from the end of the sequence and proceeding toward the beginning. With control procedures, the cue lights were turned off suddenly, rather than being faded gradually. In almost every instance, the animals learned a longer series of unlighted key positions with the fading procedures than they did when each key-light was turned off suddenly. Also, requiring the animals to press a series of keys cued by lights before they could reach the sequence members they were to learn hampered them in learning the later serial members. By using several different sequences, it was possible to replicate these findings within the individual animal.     

Training of fast tapping with reduction of kinaesthetic, tactile, visual and auditory sensations

Five subjects were trained to tap on a light Morse-key during nerve compression block. The training sessions lasted for 40 sec., with a 5 sec. rest after the first 20 sec. work period. The group learning curve reached 89.5 per cent. level of normal performance by the eighth training session. In the ninth, the testing session, subjects tapped with visual and auditory sense reduction superimposed on the kinaesthetic and tactile impariment of the training condition. Performance in the testing session reached 40.9 per cent. of normal.

The sixth subject was trained in the same task as the other five subjects, but the training condition included elimination of cues from all four sensory channels. He reached 79.09 per cent. of his normal tapping performance in the seventh session.

These results show that the motor skill of tapping can be relearned in the absence of kinaesthetic cues. Furthermore when the subject has no conscious knowledge of any peripheral sensory cues connected with the ongoing motor activity, learning can nevertheless take place. These findings lead to the hypothesis, that skilled motor activity can be monitored by central processes alone.

During the training sessions subjects showed a tendency of tapping in groups of gradually increasing length. It is hypothesized that increased number of taps forming a group gives an indication to the possible mode of action of these central processes.