The influence of height and key on the perceptual similarity of transposed melodies

In two experiments, the perceptual similarity between a strong tonal melody and various transpositions was investigated using a paradigm in which listeners compared the perceptual similarity of a melody and its transposition with that of the same melody and another transposition. The paradigm has the advantage that it provides a direct judgment regarding the similarity of transposed melodies. The experimental results indicate that the perceptual similarity of a strong tonal melody and its transposition is mainly determined by two factors: (1) the distance on the height dimension between the original melody and its transposition (pitch distance), and (2) the distance between keys as inferred from the circle of fifths (key distance). The major part of the variance is explained by the factor pitch distance, whereas key distance explains only a small part.     

Propionibacterium granulosum KP-45 in the treatment of subacute sclerosing panencephalitis

3 groups of patients, who suffered on SSPE (without treatment, with isoprinosine therapy, combined treatment with propionibacterium granulosum and isoprinosine) are compared. The results show a favourable effect of the combined treatment in a part of the patients. They are discussed in detail.     

Phonetic analysis of speech and memory codes in beginning readers

Two experimental tasks, a speech segmentation and a short-term memory task, were presented to children who began to learn to read following either the “phonic” or the “wholeword” method. The segmentation task required the child to reverse two segments (either two phones or two syllables) in an utterance. The phonic group performed significantly better than the whole-word group in the “phonic reversal” task, but no difference appeared in the “syllable reversal” task. This indicated (1) that most children by the age of 6 years are ready to discover that speech consists of a sequence of phones and (2) that the moment at which they do it is influenced by the way they are taught to read. In the memory task, the children recalled series of visually presented items whose names either rhymed or did not. The difference in performance for the rhyming and nonrhyming series was significant in both groups. It was no greater for the phonic than for the whole-word group and was uncorrelated with the “phonic reversal” task. These results are discussed in connection with the distinction between ways of lexical access and ways of representing verbal information in short-term memory.     

How Not to Individuate Destiny: a Critique of Segun Ogungbemi’s Conception of Destiny

Philosophia - The social nature of human beings and individualistic characterizing destiny of individuals is contradictory and call for philosophical interrogation. Segun Ogungbemi has...     

The Conception of Synthetic Entities from a Personalist Perspective

Science and Engineering Ethics - Synthetic biology opens up the possibility of producing new entities not found in nature, whose classification as organisms or machines has been debated. In this...     

Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation

Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an impairment of brain cholinergic transmission. One such deficit, representative of all others, is an impairment of memory consolidation, clearly observable in a one-trial inhibitory avoidance task. Recent data suggest a role of brain histaminergic systems in the regulation of behavior, particularly inhibitory avoidance learning. Here we investigate whether histamine itself, its analog SKF-91844, or various receptor-selective histamine agonists and antagonists given into the CA1 region of the hippocampus immediately post-training can affect retention of one-trial inhibitory avoidance in rats submitted to early postnatal maternal deprivation. We found that histamine, SKF-91844 and the H2 receptor agonist, dimaprit enhance consolidation on their own and reverse the consolidation deficit induced by maternal deprivation. The enhancing effect of histamine was blocked by the H2 receptor antagonist, ranitidine, but not by the H1 receptor antagonist pyrilamine or by the H3 antagonist thioperamide given into CA1 at doses known to have other behavioral actions, without altering locomotor and exploratory activity or the anxiety state of the animals. The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus.