Genetic Counseling Considerations in the Evaluation of Families for Lynch Syndrome��A Review

Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition.     

Epistemological and ethical assessment of obesity bias in industrialized countries

Bernard Lonergan's cognitive theory challenges us to raise questions about both the cognitive process through which obesity is perceived as a behaviour change issue and the objectivity of such a moral judgment. Lonergan's theory provides the theoretical tools to affirm that anti-fat discrimination, in the United States of America and in many industrialized countries, is the result of both a group bias that resists insights into the good of other groups and a general bias of anti-intellectualism that tends to set common sense against insights that require any thorough scientific analyses. While general bias diverts the public's attention away from the true aetiology of obesity, group bias sustains an anti-fat culture that subtly legitimates discriminatory practices and policies against obese people. Although anti-discrimination laws may seem to be a reasonable way of protecting obese and overweight individuals from discrimination, obesity bias can be best addressed by reframing the obesity debate from an environmental perspective from which tools and strategies to address both the social and individual determinants of obesity can be developed. Attention should not be concentrated on individuals' behaviour as it is related to lifestyle choices, without giving due consideration to the all-encompassing constraining factors which challenge the social and rational blindness of obesity bias.     

Holding a manual response sequence in memory can disrupt vocal responses that share semantic features with the manual response

Holding an action plan in memory for later execution can delay execution of another action if the actions share a similar (compatible) feature. This compatibility interference (CI) occurs for actions that share the same response modality (e.g., manual response). We investigated whether CI can generalize to actions that utilize different response modalities (manual and vocal). In three experiments, participants planned and withheld a sequence of key-presses with the left- or right-hand based on the visual identity of the first stimulus, and then immediately executed a speeded, vocal response (‘left’ or ‘right’) to a second visual stimulus. The vocal response was based on discriminating stimulus color (Experiment 1), reading a written word (Experiment 2), or reporting the antonym of a written word (Experiment 3). Results showed that CI occurred when the manual response hand (e.g., left) was compatible with the identity of the vocal response (e.g., ‘left’) in Experiment 1 and 3, but not in Experiment 2. This suggests that partial overlap of semantic codes is sufficient to obtain CI unless the intervening action can be accessed automatically (Experiment 2). These findings are consistent with the code occupation hypothesis and the general framework of the theory of event coding (Behav Brain Sci 24:849–878, 2001a; Behav Brain Sci 24:910–937, 2001b).     

Ambivalence toward mothers who kill: an examination of 45 U.S. cases of maternal neonaticide

Public opinion about neonaticide (the killing of a newborn within the first 24 hours of life) has varied across time and cultures. Some nations have passed legislation on behalf of maternal offenders with the assumption that childbirth, a time of unique biological change, may lead to mental disturbance. The United States, however, makes no such distinction; offenders are prosecuted under general homicide laws. Nevertheless, U.S. courts often consider a mother's emotional and physical condition prior to and during delivery. This study includes 44 female offenders and 45 infant deaths and highlights society's ambivalence toward neonaticide offenders. The authors suggest that this ambivalence may be attributed to: (1) the perception that an offender's emotional and physical turmoil during the birth and homicide reduces her culpability; (2) the sentiment that neonaticide offenders are more "redeemable" than other offenders; and (3) the uncertainty about the personhood of a fetus or newborn.     

Women, piety and practice: A study of women and religious practice in Malaysia

While the definition of religion in sociology has been highly contentious, we define religion in this article as simply the acts of piety that are conducted within the religious sphere. The point of this definition is to draw attention to practice and away from belief. This approach to religion appears to be especially useful in the case of contemporary Islam, where female piety has become a significant aspect of religious renewal. The idea of a religious sphere is taken from the work of Luc Boltanski and his colleagues who have coined the expression ‘the inspirational city’. Religion thus consists of acts of piety within the inspirational city, where this space is seen to be in tension with the secular city. The measurement of piety in everyday life sharply differentiates the profane world from religion. These ideas are explored in this article through qualitative data that are drawn from a small sample of pious women in contemporary Malaysia. We explore three aspects of female piety: veiling, polygamy and child-rearing. The article attempts to understand the terms in which piety is measured within the broader context of the Islamization of public life in Malaysia.     

Risk factors associated with suicide attempts and other self-injury among Hong Kong adolescents

This study examined 1,361 Chinese adolescents who reported self-injurious behaviors. Groups A and B both acknowledged deliberate self-injury, but only Group A had made a suicide attempt. Group C reported accidental self-injury. Deliberate self-injurers (Groups A and B) were more frequently girls, older, and with more suicidal ideation. Group A had more psychopathology, environmental and suicide-related risk factors than group B and C. Group C had higher depressive symptoms than noninjured controls. The study clarifies differences among self-injurious behavior groups based on expressed deliberate self-injury and self-reported suicide attempt. These three groups appear to present a continuum of risk.     

Hands-free versus hand-held cell phone conversation on a braking response by young drivers

As some states allow motorists to use hands-free cell phones only while driving, this study was done to examine some braking responses to see if conversing on these two types of cell phones affects quick responding. College-age drivers (n=25) completed reaction time trials in go/no-go situations under three conditions: control (no cell phone or conversation), and conversing on hands-free and hand-held cell phones. Their task involved moving the right foot from one pedal to another as quickly as possible in response to a visual signal in a lab setting. Significantly slower reaction times, movement times, and total response times were found for both cell phone conditions than for the control but no differences between hands-free and hand-held phone conditions. These findings provide additional support that talking on cell phones, regardless if it is hands-free or hand-held, reduces speed of information processing.     

Demographic Indicators as Predictors of Future Time Perspective

The present investigation examined the relationships between five demographic variables (age, sex, income, marital status, and education) and future time perspective. From a theoretical perspective, these demographic indicators were conceptualized as proxy measures for the social forces that influence the adult expression of this personality dimension. Data were drawn from six investigations in which a brief measure of future time perspective (Hershey and Mowen in The Gerontologist 40:687–697, 2000) had been administered to one thousand four hundred and ninety eight individuals. Higher future time perspective scores (i.e., longer future orientations) were associated with being male, increased age, income, and educational level. These main effects, however, were mitigated by a significant three-way interaction among sex, age, and level of education. These findings suggest that a complex interplay of variables is responsible for the expression of personality traits at the individual level.     

Psychological Foundations of Financial Planning for Retirement

Little is known about the psychological mechanisms that underlie financial planning for retirement. Most studies of financial planning and investing have used demographic indicators (e.g., age, gender, income) to predict individual differences in saving. In the present study, a model of planning is tested in which psychological indicators (future time perspective, retirement goal clarity, and self-rated financial knowledge) are posited to mediate the relationship between demographic indicators and saving behaviors. Path-analytic techniques were used to test the model, based on data from 265 middle-aged working adults. Analyses revealed substantial support for the role of psychological factors in the retirement planning process. Findings have theoretical implications for the development of psychologically based models of planning, as well as applied implications for those who seek to understand the psychomotivational forces that underlie tendencies to plan and save.     

Relationship Between Sensory Deficits and Externalizing Behaviors in an Urban, Latino Preschool Population

This study examined the relationship between sensory deficits and externalizing behavior problems in preschool children. Parents of 179 urban, Latino preschool children completed two parent-report measures, the Short Sensory Profile (SSP), as a checklist for sensory symptoms, and the Achenbach Checklist for Ages 1½–5 (CBCL/1½–5) to assess externalizing behavior problems. Measures were available in Spanish or English depending on the parent’s preference. Correlations were performed between the total sensory deficits scale of the SSP and the Oppositional Defiant Disorder, Attention Deficit Hyperactivity Disorder, and Externalizing Problems scales of the CBCL. Significant correlations were found between increasing levels of sensory deficits and increasing externalizing behavior problems. Correlations were also examined in subcategories of age, gender and socioeconomic status. Five-year-old children showed stronger correlations than 4-year-old children, while males showed stronger correlations than females, and the highest correlations were found in children of families reporting between $18,001 and $24,000 per year annual income. Findings suggest that Latino preschool children with externalizing behavior problems may suffer from delays in sensory development that impact their behavior. Clinical interventions should promote strategies that either reduce or increase environmental stimuli in accordance with the sensory abilities of the individual child.