The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.

Immediate post-training subcutaneous administration of lysine vasopressin (LVP, 0.003-1.00 microgram/kg) enhanced retention, whereas the vasopressin antagonist AAVP (0.01-0.30 microgram/kg) impaired it, in male Swiss mice tested 48 h after training in an inhibitory avoidance task. Both effects were dose-dependent. Neither LVP nor AAVP affected response latencies in mice not given the footshock on the training trial. The simultaneous administration of AAVP at a dose (0.01 microgram/kg) which had no effect on retention shifted the dose-response curve of LVP to the right. Nicotine (1.0-30.0 micrograms/kg, sc), a central nicotinic cholinergic agonist, also facilitated retention in a dose-related manner without affecting the retention performance of unshocked mice. The effect of nicotine was prevented by the central acting nicotinic cholinergic receptor antagonist mecamylamine (5 mg/kg, sc.). In contrast, neither hexamethonium (5 mg/kg, sc), a peripheral acting nicotinic receptor blocker, nor atropine (0.5 mg/kg, sc) or methylatropine (0.5 mg/kg, sc), two anticholinergic drugs which are known to act on muscarinic cholinergic receptors, prevented the effect of post-training nicotine. The effects of LVP and nicotine were time-dependent, suggesting that both treatments enhanced retention by influencing post-training processes involved in memory storage. Low doses of nicotine (1.50 microgram/kg, sc) or the central anticholinesterase physostigmine (35 micrograms/kg, sc) and LVP (0.003 microgram/kg, sc), which had no effect on retention when administered alone, produced a synergistic interaction when given together following training. The influence of LVP (0.03 microgram/kg, sc) on retention was prevented not only by AAVP (0.01 microgram/kg, sc) but also by mecamylamine (5 mg/kg, sc), whereas the effects of nicotine (10.0 micrograms/kg, sc) were prevented only by mecamylamine. These results suggest that the enhancement of retention induced by vasopressin is probably due to an activation of central nicotinic cholinergic mechanisms which are critical for memory formation.     

Perceptions of primary supervisor interpersonal skills: A critical incident analysis

This study surveyed a randomly selected group of Approved Supervisors of the American Association for Marriage and Family Therapy (n = 280) and their supervisees (n = 266) on their perceptions of the primary supervisor interpersonal skill used in supervisory incidents that had a positive effect on supervisee development. Supervisor directiveness was the most identified skill by both supervisors and supervisees.This study was funded in part by grants from the Research Committee of the American Association for Marriage and Family Therapy; the Agricultural Experiment Station, Purdue University; and the School of Liberal Arts and Sciences, Purdue University Calumet.     

A note on partitioned determinants

A formula for the determinant of a partitioned matrix, possibly with singular submatrices, is derived and applied to some psychometric and numerical problems.     

Generalized eigenvalue problems with positive semi-definite matrices

In a recent paper in this journal McDonald, Torii, and Nishisato show that generalized eigenvalue problems in which both matrices are singular can sometimes be solved by reducing them to similar problems of smaller order. In this paper a more extensive analysis of such problems is used to sharpen and clarify the results of McDonald, Torii, and Nishisato. Possible extensions are also indicated. The relevant mathematical literature is reviewed briefly.     

Is three greater than five: The relation between physical and semantic size in comparison tasks

In this study, subjects were asked to judge which of two digits (e.g., 3 5) was larger either in physical or in numerical size. Reaction times were facilitated when the irrelevant dimension was congruent with the relevant dimension and were inhibited when the two were incongruent (size congruity effect). Although judgments based on physical size were faster, their speed was affected by the numerical distance between the members of the digit pair, indicating that numerical distance is automatically computed even when it is irrelevant to the comparative judgment being required by the task. This finding argues for parallel processing of physical and semantic information in this task.     

The future case: An alternative to single case study

Traditional single case studies have tended to focus on the individual's past and/or present with minimal reference to one's future. This allows for an incomplete assessment of the reality in which humans participate as organisms-in-process. The future case is advanced as a complement to traditional single case designs. Emphasis is upon imaginative and creative involvement with one's future in the clinical setting. The rationale and concrete outline for this future invention process reflect how individuals can move beyond restricting conditions to higher levels of emotional growth and satisfaction.