Awareness and Preferences Regarding <Emphasis Type="Italic">BRCA1/2</Emphasis> Genetic Counseling and Testing Among Latinas and Non-Latina White Women at Increased Risk for Hereditary Breast and Ovarian Cancer

This study was an investigation of awareness, cognitions, and psychosocial and educational needs related to genetic counseling and testing among Latinas and non-Latina whites at increased risk for having a BRCA1/2 mutation. Sixty-three Latina and eighty-four non-Latina white women completed telephone surveys employing a mixture of quantitative and qualitative questions assessing awareness, benefits, risks, barriers, and genetic counseling communication preferences regarding BRCA1/2 testing. Among participants who had not previously had genetic counseling/testing, 56.9% of Latinas (29/51) and 34.8% of non-Latina white participants (24/69) were unaware of the availability of BRCA1/2 testing. In multivariate logistic regression analysis, Latina ethnicity was the only statistically significant independent factor associated with lack of awareness (OR = 0.42; 95% CI = 0.19–0.35). No appreciable differences were noted between ethnic groups regarding perceived benefits of BRCA1/2 testing or desired genetic counseling topics. These findings underscore the importance of increasing awareness of cancer genetic counseling and genetic testing among both Latina and non-Latina white populations.     

Bidirectional plasticity in striatonigral synapses: a switch to balance direct and indirect basal ganglia pathways

There is no hypothesis to explain how direct and indirect basal ganglia (BG) pathways interact to reach a balance during the learning of motor procedures. Both pathways converge in the substantia nigra pars reticulata (SNr) carrying the result of striatal processing. Unfortunately, the mechanisms that regulate synaptic plasticity in striatonigral (direct pathway) synapses are not known. Here, we used electrophysiological techniques to describe dopamine D(1)-receptor-mediated facilitation in striatonigral synapses in the context of its interaction with glutamatergic inputs, probably coming from the subthalamic nucleus (STN) (indirect pathway) and describe a striatonigral cannabinoid-dependent long-term synaptic depression (LTD). It is shown that striatonigral afferents exhibit D(1)-receptor-mediated facilitation of synaptic transmission when NMDA receptors are inactive, a phenomenon that changes to cannabinoid-dependent LTD when NMDA receptors are active. This interaction makes SNr neurons become coincidence-detector switching ports: When inactive, NMDA receptors lead to a dopamine-dependent enhancement of direct pathway output, theoretically facilitating movement. When active, NMDA receptors result in LTD of the same synapses, thus decreasing movement. We propose that SNr neurons, working as logical gates, tune the motor system to establish a balance between both BG pathways, enabling the system to choose appropriate synergies for movement learning and postural support.     

HIV and depression--a systematic review of interventions

HIV-positive individuals are more likely to be diagnosed with major depressive disorder than HIV-negative individuals. Depression can precede diagnosis and be associated with risk factors for infection. The experience of illness can also exacerbate depressive episodes and depression can be a side effect to treatment. A systematic understanding of which interventions have been tested in and are effective with HIV-seropositive individuals is needed. This review aims to provide a comprehensive understanding of evaluated interventions related to HIV and depression and provide some insight on questions of prevalence and measurement. Standard systematic research methods were used to gather quality published papers on HIV and depression. From the search, 1015 articles were generated and hand searched resulting in 90 studies meeting adequacy inclusion criteria for analysis. Of these, 67 (74.4%) were implemented in North America (the US and Canada) and 14 (15.5%) in Europe, with little representation from Africa, Asia and South America. Sixty-five (65.5%) studies recruited only men or mostly men, of which 31 (35%) recruited gay or bisexual men. Prevalence rates of depression ranged from 0 to 80%; measures were diverse and rarely adopted the same cut-off points. Twenty-one standardized instruments were used to measure depression. Ninety-nine interventions were investigated. The interventions were diverse and could broadly be categorized into psychological, psychotropic, psychosocial, physical, HIV-specific health psychology interventions and HIV treatment-related interventions. Psychological interventions were particularly effective and in particular interventions that incorporated a cognitive-behavioural component. Psychotropic and HIV-specific health psychology interventions were generally effective. Evidence is not clear-cut regarding the effectiveness of physical therapies and psychosocial interventions were generally ineffective. Interventions that investigated the effects of treatments for HIV and HIV-associated conditions on depression generally found that these treatments did not increase but often decreased depression. Interventions are both effective and available, although further research into enhancing efficacy would be valuable. Depression needs to be routinely logged in those with HIV infection during the course of their disease. Specific data on women, young people, heterosexual men, drug users and those indiverse geographic areas are needed. Measurement of depression needs to be harmonized and management into care protocols incorporated.     

Trait Meta-Mood and Subjective Happiness: A 7-week Prospective Study

The primary aim of the current study was to replicate and extend previous findings by examining the relationship between trait meta-mood and levels of subjective happiness in a 7-week follow-up study. Participants were 192 undergraduate students (155 females) who completed self-report measures of trait meta-mood and subjective happiness. After 7 weeks, 155 students completed the subjective happiness scale again. Focusing first on cross-sectional analysis, meta-mood dimensions were found to be moderately related to levels of subjective happiness. Next, along with initial levels of subjective happiness, we found that meta-mood dimensions independently predicted prospective levels of subjective happiness over a 7-week follow-up. These findings provide some preliminary evidence on the prospective value of meta-mood dimensions as relevant individual differences involved in the maintenance of emotional well-being indicators.     

Investigating the relationship between meaningful time use and health in 18‐ to 25‐year‐old unemployed people in New South Wales,Australia

A vast body of literature has reported on the association between unemployment and poor psychological health. Nonetheless, there remains limited understanding of the influence of meaningfulness of time use, suggested by some to be the key mediator between time use and health. This project set out to explore the association between meaningful time use and health in 18‐ to 25‐year‐old unemployed people. In April 2007, 150 unemployed 18‐ to 25‐year‐old Australians (56% female) completed an online survey package exploring meaningfulness of time use and health. Hierarchical stepwise regression equations were developed to analyse the relationship between psychological health and measures of meaningful time use. Results provided partial support for the hypothesis that measures of meaningful time use would contribute to the prediction of psychological health. The addition of the person measure for the combined construct of ‘meaningful time use’ failed to make a significant contribution towards the prediction of psychological health. However, ‘reason for doing the activity’ emerged as a significant predictor. Findings provide preliminary evidence for the establishment of activity‐based programs to support young unemployed people. Further research is required to evaluate the outcomes of such programs and to replicate this study with other groups of unemployed individuals. Copyright © 2010 John Wiley & Sons, Ltd.     

Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Several prior imaging studies of healthy adults have correlated volumes of the hippocampus and amygdala with measures of general intelligence (IQ), with variable results. In this study, we assessed correlations between volumes of the hippocampus and amygdala and full-scale IQ scores (FSIQ) using a method of image analysis that permits detailed regional mapping of this correlation throughout the surface contour of these brain structures. We delineated the hippocampus and amygdala in high-resolution magnetic resonance images of the brain from 34 healthy individuals. We then correlated FSIQ with overall volumes and with the surface morphologies of each of these structures. Hippocampus volumes correlated significantly and inversely with FSIQ independently of gender, age, socioeconomic status, and whole brain volume. Left and right hippocampus volumes correlated respectively with verbal and performance IQ subscales. Higher IQs were significantly associated with large inward deformations of the surface of the anterior hippocampus bilaterally. These findings suggest that a smaller anterior hippocampus contributes to an increased efficiency of neural processing that subserves overall intelligence.     

The effect of personality variables in the prediction of the execution of different prospective memory tasks in the laboratory

The study of prospective memory (ProM), the remembering of the delayed execution of intentions, has been growing in recent years, and we know quite a bit about the cognitive variables that affect it. But the performance of a task depends on personality variables as well as on cognitive ones, and the role of personality variables in ProM has only been partially studied, the results being less conclusive. We sought to address two main objectives: (1) to quantify the joint influence of cognitive and personality variables on three ProM tasks in the laboratory (two based on events and the other on time), and (2) to identify the personality profiles of those who perform well in these three ProM tasks as opposed to those who do not. The cognitive and personality variables were evaluated with two sessions of 157 participants. The 16 PF-5 was applied (Cattell, Cattell & Cattell, 1993) and other cognitive variables were measured. With the data obtained, we ran several regression analyses to determine how some cognitive variables (sustained attention, verbal fluency, interference, retrospective memory, selective attention) and personality factors (tested using the 16 PF-5) can help to explain the variance in the performance of prospective memory tasks. Our results show that the contribution of personality predictor variables is moderate and smaller than that of the cognitive variables for predicting the execution of ProM tasks in the laboratory. Furthermore the intervention of the personality variables differs depending on the ProM tasks used. Global self-control and rule-consciousness were the personality variables that contributed the most in the prediction of the scores in the ProM tasks that were used.     

When and how do differences matter? An exploration of perceived similarity in teams

In this paper, we directly assess perceived similarity—the degree to which members view themselves as having few differences—because we want to understand when teams notice diversity on various member characteristics and how they interpret it. Our results indicate social category diversity was related to initial estimates of both perceived social category similarity (SCS) and perceived work style similarity (WSS). And, whereas perceived SCS did not change over time, perceived WSS decreased significantly over the period of our study. We suggest this change in perceived WSS can be explained by an information-processing/decision-making framework. We found informational diversity was positively related to conflict in teams, and in turn conflict was negatively related to subsequent estimates of perceived WSS. However, informational diversity was positively related to information sharing in teams, which in turn was positively related to subsequent estimates of perceived WSS. Finally, these updated estimates of perceived WSS affected subgroup formation and team process effectiveness. We discuss how our research explores the subjective experience of diversity by team members, provides a dynamic view of the relationship between diversity and team outcomes, and informs emerging theory about the activation of faultlines in teams.     

The Basic Constructive Logic for a Weak Sense of Consistency defined with a Propositional Falsity Constant

The logic B_Kc1 is the basic constructive logic in the ternaryrelational semantics (without a set of designated points) adequateto consistency understood as the absence of the negation ofany theorem. Negation is introduced in B_Kc1 with a negationconnective. The aim of this paper is to define the logic B_Kc1F.In this logic negation is introduced via a propositional falsityconstant. We prove that B_Kc1 and B_Kc1F are definitionally equivalent.