State-Space Analysis of Working Memory in Schizophrenia: An FBIRN Study

The neural correlates of working memory (WM) in schizophrenia (SZ) have been extensively studied using the multisite fMRI data acquired by the Functional Biomedical Informatics Research Network (fBIRN) consortium. Although univariate and multivariate analysis methods have been variously employed to localize brain responses under differing task conditions, important hypotheses regarding the representation of mental processes in the spatio-temporal patterns of neural recruitment and the differential organization of these mental processes in patients versus controls have not been addressed in this context. This paper uses a multivariate state-space model (SSM) to analyze the differential representation and organization of mental processes of controls and patients performing the Sternberg Item Recognition Paradigm (SIRP) WM task. The SSM is able to not only predict the mental state of the subject from the data, but also yield estimates of the spatial distribution and temporal ordering of neural activity, along with estimates of the hemodynamic response. The dynamical Bayesian modeling approach used in this study was able to find significant differences between the predictability and organization of the working memory processes of SZ patients versus healthy subjects. Prediction of some stimulus types from imaging data in the SZ group was significantly lower than controls, reflecting a greater level of disorganization/heterogeneity of their mental processes. Moreover, the changes in accuracy of predicting the mental state of the subject with respect to parametric modulations, such as memory load and task duration, may have important implications on the neurocognitive models for WM processes in both SZ and healthy adults. Additionally, the SSM was used to compare the spatio-temporal patterns of mental activity across subjects, in a holistic fashion and to derive a low-dimensional representation space for the SIRP task, in which subjects were found to cluster according to their diagnosis.     

A meta‐mood model of rumination and depression: Preliminary test in a non‐clinical population

Depressive rumination and trait meta‐mood (emotional attention, emotional clarity and emotional repair) have been suggested as vulnerability factors leading to depression, but less is known about the associations among them. In this study, we examined the relationships between trait meta‐mood, rumination and depressive symptomatology. Using structural equation analysis in a large sample of a non‐clinical population we found a preliminary test of the role of trait meta‐mood dimensions in rumination and depressive symptomatology. Results indicated that attention to feelings has two pathways in its relation with rumination and depressive mood. On the one hand, emotional attention was associated with emotional clarity, and emotional clarity with emotional repair, which was related to lower depressive symptomatology, in part, by reducing rumination. On the other hand, emotional attention was directly associated with ruminative thoughts which, in turn, were related to higher depressive mood. Findings are discussed in terms of the implications of beliefs about emotions in the treatment of depression.     

Der verborgene Gott in der Theologie Werner Elerts

The re-formulation of conflicts, it has been claimed, is an important step towards reaching reconciliation in countries torn by conflicts. In this article I shall discuss reconciliation on the basis of my analysis of the nationalist theology of Sr. Pinochet and the alternative theological canons of people living in poverty in post-dictatorial Chile.1 1. Lene Sj?rup, Pinochets gud – og de fattiges teologiske modstand (K?benhavn: Museum Tusculanum, 2008); Lene Sj?rup, “Pinochets stedfortrædende lidelse og forsoning,” in Vendepunkter: Religion mellem konflikt og forsoning (ed. Lene Sj?rup; Odense: Syddansk Universitetsforlag, 2007); Lene Sj?rup, ”Pinochet as protector of and martyr for Christianity in Chile,” Nordic Journal of Religion and Society 19/2 (2006), 43-55. Reconciliation in the classical theological sense, my analysis indicates, is in itself part of these canons and therefore also of national conflicts. Religion does, however, play a major global, national, local and individual role in conflict resolution. This, I argue, indicates that there is more to conflict resolution than different canons of reconciliation. Conflicts are perceived as not only rupturing horizontal relationships between humans, but also vertical relationships with the divine. Conflict resolution, therefore, also involves the reparation of this relation. This paper discusses, using Chile as an example, the theological importance of memory work, the redefinition of space, and ritual as a means of repairing horizontal, as well as vertical, relations.     

Domains of Sciences,Universes of Discourse and Omega Arguments

Each science has its own domain of investigation, but one and the same science can be formalized in different languages with different universes of discourse. The concept of the domain of a science and the concept of the universe of discourse of a formalization of a science are distinct, although they often coincide in extension. In order to analyse the presuppositions and implications of choices of domain and universe, this article discusses the treatment of omega arguments in three very different formalizations of arithmetic. In Peano's formalization the domain is a restricted class of individuals, while the universe of discourse is the unrestricted class of all individuals. In Gödel's formalization the domain is a restricted class of individuals as in Peano's formalization, but the universe of discourse coincides with the domain. In Whitehead-Russell's formalization the domain is a class of logical notions in Tarski's sense, that are necessarily not individuals, whereas the universe of discourse is the unrestricted class of individuals as in Peano's formalization. The present approach emphasizes the viewpoint that the universe of discourse of a given discourse is important in determining which propositions are expressed by which sentences.     

Influences of culture and visual context on real-time social categorization

Social categorization is often thought to be based on facial features and immune to visual context. Moreover, East Asians have been argued to attend to context more than Westerners. American and Chinese participants were presented with faces varying along a White-Asian morph continuum either in American, neutral, or Chinese contexts. American contexts made White categorizations more likely, and Chinese contexts made Asian categorizations more likely. Further, the compatibility between facial and contextual cues influenced the directness of participants' hand trajectories en route to selecting a category response. Even when an ultimate response was not biased by context, the trajectory was nevertheless partially attracted to the category response associated with the context. Importantly, such partial attraction effects in hand trajectories revealed that the influence of context began earlier in time for Chinese relative to American participants. Together, the results show that context systematically influences social categorization, sometimes altering categorization responses and other times only temporarily altering the process. Further, the timing of contextual influences differs by culture. The findings highlight the role of contextual and cultural factors in social categorization.     

Influence of Mass Media on Body Image and Eating Disordered Attitudes and Behaviors in Females: A Review of Effects and Processes

This article reviews research on the effects of television and magazines on body image and on disordered eating attitudes and behaviors in females. Evidence from different types of studies in the fields of eating disorders, media psychology, health psychology, and mass communication indicates that mass media are an extremely important source of information and reinforcement in relation to the nature of the thin beauty ideal, its importance, and how to attain it. Although considerable research remains to be done, evidence is accumulating that repeated exposure to media and to both direct and indirect (via media's effects on peers, parents, coaches, physicians, etc.) pressures from media to be thin constitute risk factors for body dissatisfaction, concerns over weight and disordered eating behaviors in adolescent girls and young women. To guide further research, as well as the prevention and treatment of disordered eating, we present a figural summary of media effects that integrates moderating and mediating factors such as internalization of the thin beauty ideal, social comparison, and activation of the thinness schema. We argue that risk factor research, prevention, and treatment will benefit from systematic research designed to clarify how the impact of various mass media is shaped by source and receiver/perceiver factors.     

Young Children's Sensitivity to Speaker Gender When Learning From Others

This research explores whether young children are sensitive to speaker gender when learning novel information from others. Four- and 6-year-olds (N = 144) chose between conflicting statements from a male versus a female speaker (Studies 1 and 3) or decided which speaker (male or female) they would ask (Study 2) when learning about the functions of novel objects. Some objects were in gender-typing colors (light pink or navy blue), and some were in a gender-ambiguous color (yellow). The results indicated that children did use speaker gender to guide their learning, by either consistently choosing to agree with the speakers of their own gender or making choices that are associated with gender stereotypes about color. The findings are discussed in relation to how in-group preference and stereotype attributions might influence children's learning from others.     

A system for automatic recording and analysis of motor activity in rats

We describe the design and evaluation of an electronic system for the automatic recording of motor activity in rats. The device continually locates the position of a rat inside a transparent acrylic cube (50 cm/side) with infrared sensors arranged on its walls so as to correspond to the x-, y-, and z-axes. The system is governed by two microcontrollers. The raw data are saved in a text file within a secure digital memory card, and offline analyses are performed with a library of programs that automatically compute several parameters based on the sequence of coordinates and the time of occurrence of each movement. Four analyses can be made at specified time intervals: traveled distance (cm), movement speed (cm/s), time spent in vertical exploration (s), and thigmotaxis (%). In addition, three analyses are made for the total duration of the experiment: time spent at each x–y coordinate pair (min), time spent on vertical exploration at each x–y coordinate pair (s), and frequency distribution of vertical exploration episodes of distinct durations. User profiles of frequently analyzed parameters may be created and saved for future experimental analyses, thus obtaining a full set of analyses for a group of rats in a short time. The performance of the developed system was assessed by recording the spontaneous motor activity of six rats, while their behaviors were simultaneously videotaped for manual analysis by two trained observers. A high and significant correlation was found between the values measured by the electronic system and by the observers.