Predictors of psychological outcomes in a longitudinal study of Latina breast cancer survivors

Objective: This study sought to investigate the unique contributions of socio-ecological, cultural and cancer treatment-related factors in predicting depressive symptoms and cancer-specific distress among Latinas. Design: Participants were 140 English or Spanish-speaking Latinas (M_age = 50.6) with non-metastatic breast cancer who were assessed within two years of diagnosis (Time 1) and three months later (Time 2).

Main Measures: Hierarchical regression analyses identified predictors of depressive symptoms and cancer-specific distress at Time 1 and 2.

Results: Most women scored above the clinical cut-offs for depressive symptoms and cancer-specific distress. After adjusting for socio-ecological factors, greater Latino enculturation, measured by Latino ethnic identity, was significantly associated with greater cancer-specific distress at Time 1 (β = .20, p < .05). A significant interaction (p < .01) revealed that among women high on Latino identity, lower English language use was associated with more cancer-specific distress than higher English language use. After adjusting for socio-ecological factors, greater satisfaction with surgical treatment predicted improved depressive symptoms and cancer-specific distress across time (β_s range from ?.31 to ?.18, p_s < .01).

Conclusions: Findings elucidate the complex relationship between culture and psychological outcomes in the breast cancer context and suggest that treatment satisfaction might be an important intervention target for Latinas.     

Transformational Growth and Poverty: An Evolutionary Approach for Inter-Country and Inter-Temporal Comparisons of Poverty Incidence

Within the development literature three accords seem to have taken place regarding poverty measurement. These relate to the relative or absolute measurement of poverty, the monetary versus basic needs measurement, and the existence of an international poverty line. In this paper, all three of these accords are challenged from an evolutionary perspective. A framework is presented to show how the poverty line (as well as the nature and characteristics of poverty) evolve as countries go through the process of changing consumption and production patterns that increases average income, i.e., transformational growth. Based on this framework, an answer to the problem of how to compare poverty rates through long periods of time is developed. It results in an absolute poverty line (rather than a relative one), which changes through time. This approach is shown to be better (because it is not mechanical) than the income-elasticity of the poverty line for inter-temporal comparisons. It is not mechanical because the poverty line is not adjusted by the change in average income but on the socially determined, evolving, acceptable minima to participate in society. It is also found to avoid the limitations of the currently used "international poverty lines.“ Finally, a similar approach is used to develop a method of adjusting the measurement of poverty based on basic needs, i.e., using a matrix of social deprivations rather than a monetary poverty line. This is done using the methodology developed by UNICEF, the University of Bristol, and the London School of Economics to measure child poverty based on deprivation of rights, which constitute poverty. This method has been applied in over 70 countries world-wide.     

THE REBIRTH OF THE IDOLS: THE FREUDIAN UNCONSCIOUS AND THE NIETZSCHEAN UNCONSCIOUS3

The author explores how psychoanalysis mutates in its passing from the privacies of the session to the public spaces of academia, shifting away from enquiry into unfolding unconscious psychic processes guided by its method, and from the clinically based notions Freud and his diverse followers constructed, here called the ‘Freudian unconscious’. In postmodern intellectual contexts Freud's work fuels a ‘Nietzschean unconscious’, issuing from public lecterns in the protagonistic, self‐creating feats of a ‘psychoanalytic discourse’. The ideology of such mutation ishere traced from Nietzsche on to Heidegger and Kojave, and then to Lacan and Laplanche. It reflects the might of the ‘death of evidences’ and the Romantic penchant for the limit‐experience and the primacy accorded to the creative imagination. Discourse as revelation rests on a ‘paradox of the enunciation’ whereby the subject (author) of the statement is taken to be identical to the subject (matter) of the statement. Banishing the boundaries of illusion and evidence, and of self‐overcoming and insight, academic ‘psychoanalytic discourse’creates a ‘return of the idols’ in ‘theoretical’ narcissistic identification.     

Development of a computer program to simulate the predictions of the replaced elements model of Pavlovian conditioning

Despite of the apparent simplicity of Pavlovian conditioning, research on its mechanisms has caused considerable debate, such as the dispute about whether the associated stimuli are coded in an "elementistic"(a compound stimuli is equivalent to the sum of its components) or a "configural" (a compound stimuli is a unique exemplar) fashion. This controversy is evident in the abundant research on the contrasting predictions of elementistic and the configural models. Recently, some mixed solutions have been proposed, which, although they have the advantages of both approaches, are difficult to evaluate due to their complexity. This paper presents a computer program to conduct simulations of a mixed model ( replaced elements model or REM). Instructions and examples are provided to use the simulator for research and educational purposes.     

Attitudes, learning experience and performance in mathematics: gender differences

In this paper, we used the data of Mathematics achievements from the sample of 13- year-old Spanish boys and girl who took part in the Second National Assessment of Educational Progress, carried out by the Educational Testing Service. With the aim of identifying variables related to high achievement, our goals are: 1) to analyse whether there are significant differences in 13-year-old Spanish boys and girls in their attitudes towards mathematics, their study strategies, and their performance; 2) to analyse the influence of their attitudes and study strategies on their performance, and to examine whether these relations are the same in boys and girls; 3) to propose a theoretical model that explains the relationship among the variables defined by means of structural equation modelling. The results show that: a) there are significant differences between boys and girls in the variables studied; b) it is not possible to reject the proposed model that relates study strategies and attitudes towards performance in mathematics; and c) the model tends to be stable both among boys and girls.     

The locus of the frequency effect in picture naming: When recognizing is not enough

The lexical frequency effect in picture naming is generally assumed to constitute a signature of lexical access. Lexical frequency, however, is correlated with other variables, like concept familiarity, that can produce effects similar to those of lexical frequency in picture naming tasks. In this study, a delayed picture naming task was employed to address the hypothesis that the frequency effect in picture naming is due to variables that affect processing in the perceptual and semantic identification stages (i.e., input stages). Despite the fact that all the input processing stages were completed prior to the presentation of the naming cue, a strong frequency effect was still obtained in this task. These results establish that the lexical frequency effect is independent of variables affecting the input stages of picture naming, and, hence, confirm the lexical frequency effect as a signature effect of lexical access.     

On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory

Upon retrieval, consolidated memories are again rendered vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led to the hypothesis that memories are reconsolidated at the time of retrieval, and that this depends on protein synthesis. Ample evidence indicates that the hippocampus plays a key role both in the consolidation and reconsolidation of different memories. Despite this fact, at present there are no studies about the consequences of hippocampal protein synthesis inhibition in the storage and post-retrieval persistence of object recognition memory. Here we report that infusion of the protein synthesis inhibitor anisomycin in the dorsal CA1 region immediately or 180 min but not 360 min after training impairs consolidation of long-term object recognition memory without affecting short-term memory, exploratory behavior, anxiety state, or hippocampal functionality. When given into CA1 after memory reactivation in the presence of familiar objects, ANI did not affect further retention. However, when administered into CA1 immediately after exposing animals to a novel and a familiar object, ANI impaired memory of both of them. The amnesic effect of ANI was long-lasting, did not happen after exposure to two novel objects, following exploration of the context alone, or in the absence of specific stimuli, suggesting that it was not reversible but was contingent on the reactivation of the consolidated trace in the presence of a salient, behaviorally relevant novel cue. Our results indicate that hippocampal protein synthesis is required during a limited post-training time window for consolidation of object recognition memory and show that the hippocampus is engaged during reconsolidation of this type of memory, maybe accruing new information into the original trace.     

Cholinergic afferents to the locus coeruleus and noradrenergic afferents to the medial septum mediate LTP-reinforcement in the dentate gyrus by stimulation of the amygdala

Transient long-term potentiation (E-LTP) can be transformed into a long-lasting LTP (L-LTP) in the dentate gyrus (DG) by behavioral stimuli with high motivational content. Previous research from our group has identified several brain structures, such as the basolateral amygdala (BLA), the locus coeruleus (LC), the medial septum (MS) and transmitters as noradrenaline (NA) and acetylcholine (ACh) that are involved in these processes. Here we have investigated the functional interplay among brain structures and systems which result in the conversion of a E-LTP into a L-LTP (reinforcement) by stimulation of the BLA (BLA-R). We used topical application of specific drugs into DG, and other targets, while following the time course of LTP induced by stimulation of the perforant pathway (PP) to study their specific contribution to BLA-R. One injection cannula, a recording electrode in the DG and stimulating electrodes in the PP and the BLA were stereotactically implanted one week before electrophysiological experiments. Topical application of atropine or propranolol into the DG blocked BLA-R in both cases, but the effect of propranolol occurred earlier, suggesting a role of NA within the DG during an intermediate stage of LTP maintenance. The injection of lidocaine into the LC abolished BLA-R indicating that the LC is part of the functional neural reinforcing system. The effect on the LC is mediated by cholinergic afferents because application of atropine into the LC produced the same effect. Injection of lidocaine inactivating the MS also abolished BLA-R. This effect was mediated by noradrenergic afferents (probably from the LC) because the application of propranolol into the MS prevented BLA-R. These findings suggest a functional loop for BLA-R involving cholinergic afferents to the LC, a noradrenergic projection from the LC to the DG and the MS, and finally, the cholinergic projection from the MS to the DG.