mTOR signaling in the hippocampus is necessary for memory formation

It is widely accepted that the formation of long-term memory (LTM) requires mRNA translation, but little is known about the cellular mechanisms in the brain that regulate this process. Mammalian target of rapamycin (mTOR) is a key regulator of translational efficacy and capacity. Here, we show that LTM formation of one-trial inhibitory avoidance (IA) in rats, a hippocampus-dependent fear-motivated learning task, requires mTOR activation. IA training is specifically associated with a rapid increase in the phosphorylation state of mTOR and its substrate ribosomal S6 kinase (p70S6K). Bilateral intra-CA1 infusion of rapamycin, a selective mTOR inhibitor, 15 min before, but not immediately after training completely hinders IA LTM without affecting short-term memory (STM) retention. Therefore, our findings indicate that the regulation of hippocampal mRNA translation is a major control step in memory consolidation.     

Seven principles of goal activation: a systematic approach to distinguishing goal priming from priming of non-goal constructs.

Countless studies have recently purported to demonstrate effects of goal priming; however, it is difficult to muster unambiguous support for the claims of these studies because of the lack of clear criteria for determining whether goals, as opposed to alternative varieties of mental representations, have indeed been activated. Therefore, the authors offer theoretical guidelines that may help distinguish between semantic, procedural, and goal priming. Seven principles that are hallmarks of self-regulatory processes are proposed: Goal-priming effects (a) involve value, (b) involve postattainment decrements in motivation, (c) involve gradients as a function of distance to the goal, (d) are proportional to the product of expectancy and value, (e) involve inhibition of conflicting goals, (f) involve self-control, and (g) are moderated by equifinality and multifinality. How these principles might help distinguish between automatic activation of goals and priming effects that do not involve goals is discussed.     

Using the Internet to find offline sex partners.

We aimed to expand upon the demographic characteristics and gender differences among those who have met someone on the Internet who they later met offline and had sex with as well as any relationship with cybersex, sexually transmitted infections, and online sexual problems. We analyzed data collected through an online questionnaire in 2002 in Sweden including a total population of 1836 respondents of which 1458 used the Internet for sexual purposes. Of those, 35% men and 40% women reported to have met offline sex partners online. The majority reported an occurrence of one to two times, whereas 10% reported six or more times. The analysis suggested women aged 34-49 and 50-65 years, homo- and bisexual men, and singles more likely to have this experience. They were also more likely to have engaged in cybersex. No relationships were found with sexually transmitted infections or online sexual problems. The results suggest that using the Internet to find sex partners may be less hazardous for the general Internet users than pointed out by prior research about this behavior often focusing on specific sub groups of Internet users.     

Moral judgments, emotions and the utilitarian brain

The investigation of the neural and cognitive mechanisms underlying the moral mind is of paramount importance for understanding complex human behaviors, from altruism to antisocial acts. A new study on patients with prefrontal damage provides key insights on the neurobiology of moral judgment and raises new questions on the mechanisms by which reason and emotion contribute to moral cognition.     

Feeling of knowing for names in response to faces

Participants were asked to recall the names when shown photographs of faces in both a semantic task (Experiment 1) and an episodic task (Experiments 2 and 3). When recall failed, feeling of knowing (FOK) ratings were solicited. In addition, participants reported on the strategies that they used to make their ratings, whether they could recall other pieces of information (the target-accessibility strategy, e.g., Koriat, A. (1993). How do we know that? The accessibility model of the feeling of knowing. Psychological Review, 100, 609–639) or whether the faces simply looked familiar (the cue-familiarity strategy, e.g., Schwartz, B. L., & Metcalfe, J. (1992). Cue familiarity but not target accessibility enhances feeling of knowing ratings. Journal of Experimental Psychology: Learning, Memory, and Cognition, 18, 1074–1083). In all experiments, FOK ratings were fairly accurate in that participants were successful in predicting their performance on a subsequent recognition test. More importantly, participants reported using the cue-familiarity strategy more often, although they gave higher FOK ratings when they reported using the target-accessibility strategy. The FOK ratings that were given using the two strategies were equally accurate.     

Mereological vagueness and existential vagueness

It is often assumed that indeterminacy in mereological relations—in particular, indeterminacy in which collections of objects have fusions—leads immediately to indeterminacy in what objects there are in the world. This assumption is generally taken as a reason for rejecting mereological vagueness. The purpose of this paper is to examine the link between mereological vagueness and existential vagueness. I hope to show that the connection between the two forms of vagueness is not nearly so clear-cut as has been supposed.     

Is the attribution of cultural differences to minorities an expression of racial prejudice?

The social psychological literature considers two main perspectives on the study of perceived cultural differences between majorities and minorities: one proposes that perception of cultural differences is an antecedent of prejudice and another states that the attribution of cultural differences to minorities is already a hidden expression of racial prejudice. This paper offers further support to this latter perspective. One hundred and ninety-four participants answered a questionnaire measuring (1) general racist belief; (2) cultural differences attributed to Black people (hetero-ethnicization); (3) the asymmetric attribution of secondary and primary emotions to the in-group and to Black people (infra-humanization); (4) the asymmetric attribution of natural and cultural traits to in-group members and to Black people (ontologization); and (5) negative evaluation of this social category. The general racist belief scale was not anchored in a specific group and measured the belief in the inferiority of certain social groups or peoples based on biological or cultural factors. Relationships between the scales were analysed through a set of Structural Equation Models. According to the predictions, results showed that the attribution of cultural differences is a dimension of prejudice. Results also showed that attribution of cultural differences, negative evaluation of Black people, ontologization, and infra-humanization were different dimensions of a common latent factor that can be identified as racial prejudice; and that prejudice was predicted by general racist belief. Results are discussed in the light of the study of the impact of perceived cultural differences on intergroup relations and in the light of the "new racism" approaches.     

A Structural Analysis of the Phlogiston Case

The incommensurability thesis, as introduced by T.S. Kuhn and P.K. Feyerabend, states that incommensurable theories are conceptually incompatible theories which share a common domain of application. Such claim has often been regarded as incoherent, since it has been understood that the determination of a common domain of application at least requires a certain degree of conceptual compatibility between the theories. The purpose of this work is to contribute to the defense of the notion of local or gradual incommensurability, as proposed by late Kuhn. The application of this notion would allow to render the incommensurability thesis coherent. To support this view, a typical example of incommensurability will be formally analyzed by applying the structuralist metatheory developed, among others by W. Balzer, C.U. Moulines and J.D. Sneed. The structural reconstruction of the relation between the phlogiston theory and the oxygen theory offered here will reveal that they are locally incommensurable, and will even make possible to determine the ontological reduction relation that they also exemplify.

---

Role of the Disease in the Psychological Impact of Pre-Symptomatic Testing for SCA2 and FAP ATTRV30M: Experience with the Disease, Kinship and Gender of the Transmitting Parent

To identify possible factors affecting the psychological impact of pre-symptomatic testing for spinocerebellar ataxia type 2 (SCA2) and familial amyloid polyneuropathy (FAP ATTRV30M), we studied (1) the effect of previous experience with the disease in the family, (2) kinship with the closest affected relative and (3) gender of affected parent, when adapting to test results; as well as (4) differences in the course of psychological wellbeing in 63 subjects ( 28 at-risk for FAP ATTRV30M, and 35 at risk for SCA2), who pursued predictive testing for these diseases, in Cuba and in Portugal. Our research shows that individuals with little or no experience with the disease in their family exhibited more anxiety; at-risk subjects for SCA2 or FAP ATTRV30M who had a first degree relative with the disease showed lower levels of anxiety and depression during pre-symptomatic testing. Also those with an affected mother had lower levels of depression, either immediately, or one year after receipt of test results. Adaptation to pre-symptomatic testing results differed for subjects at-risk for the two different conditions. Unlike the FAP ATTRV30M families, carriers for SCA2 reported pathological levels of depression immediately after-testing (3 weeks), although those levels had returned to normal levels at 6 months. Subjects at-risk for FAP ATTRV30M tended to have less anxiety than those tested for SCA2, at the one-year follow-up. Overall, depression levels improved over time, while anxiety remained more constant. A longer awareness of the disease in the family, closer kinship, and a transmitting mother all lessened the impact of pre-symptomatic testing, as expressed by the post-test levels of anxiety and depression.     

A standardized set of 260 pictures for Modern Greek: Norms for name agreement, age of acquisition, and visual complexity

The appropriate selection of both pictorial and linguistic experimental stimuli requires a previous languagespecific standardization process of the materials across different variables. Considering that such normative data have not yet been collected for Modern Greek, in this study normative data for the color version of the Snodgrass and Vanderwart picture set (Rossion & Pourtois, 2004) were collected from 330 native Greek adults. Participants named the pictures (providing name agreement ratings) and rated them for visual complexity and age of acquisition. The obtained measures represent a useful tool for further research on Greek language processing and constitute the first picture normative study for this language. The picture norms from this study and previous ones may be downloaded from brm.psychonomic-journals.org/content/supplemental.