Fetal brain tissue transplants reduce visual deficits in adult rats with bilateral lesions of the occipital cortex

Fetal brain tissue from the occipital or the frontal cortex was implanted into the damaged occipital cortex of adult rats. The animals receiving grafts of embryonic frontal cortex showed partial restoration of brightness discrimination while recipients given homologous implants of occipital cortex were as impaired as those animals with lesions alone. Neither frontal nor occipital grafts aided in the performance of a pattern discrimination problem; both groups of brain-damaged animals were unable to learn the task. Nonetheless, both groups of animals had viable and enlarged grafts with similar neuronal and glial profiles.     

Predictability,controllability, and inoculation against learned helplessness

Nondepressed human subjects were divided into seven groups. On a series of discrimination problems, a helplessness group received insoluble problems, a solvable group received contingent feedback, and a no treatment control group received no feedback. For two other groups insoluble problems were preceded by success feedback on a different task presented according to a fixed ratio (FR) or variable ratio (VR) schedule of reinforcement. Two control groups received either FR or VR schedules of success but were not examined on the discrimination problems. All groups were tested for escape/avoidance performance on a human shuttle box. Both FR and VR schedules produced an inoculation against learned helplessness; escape performance by the helplessness group was significantly worse than that of FR and VR inoculation groups. These latter groups performed similar to the solvable and three control groups. Significantly worse than that of FR and VR inoculation groups. These latter groups performed similar to the solvable and three control groups. Significantly fewer subjects in the VR inoculation group exhibited avoidance responses than their counterparts in the FR inoculation group. despite similar escape performance. The findings indicate that learned helplessness can be prevented in humans and suggest different sources of interference produced by unpredictable and uncontrollable events.     

Central deafness and subcortical motor aphasia

Clinical and autopsy studies were made on a right-handed man who had central deafness and subcortical motor aphasia, and the literature on central deafness and on subcortical motor aphasia was analyzed. Central deafness is due to bilateral destruction of the primary auditory cortex. It is sometimes difficult to distinguish from word deafness and from auditory agnosia, which are due to pathology in other parts of the temporal lobes. There is almost always some preserved hearing in central deafness, possibly from some auditory pathway other than the classical pathway. In this patient the subcortical motor aphasia was due to bilateral destruction of the motor cortex for the mouth and throat. In some other cases subcortical motor aphasia was due to the same pathology that usually causes Broca's aphasia; in these cases the unexpected preservation of writing was perhaps related to some difference in how language functions were organized in the brain.     

Production deficits in aphasia: A voice-onset time analysis

An experimental study was conducted to examine phonetic and phonemic deficits in the speech production of aphasics. Subjects included four Broca's aphasics, four Conduction aphasics, five Wernicke's aphasics, one nonaphasic dysarthric patient, and four normal controls. The subjects read a list of words containing word-initial stop consonants which were subsequently measured acoustically for voice-onset time. The results showed that Broca's aphasics exhibit a more severe production disorder than Conduction aphasics who in turn exhibit a more severe disorder than Wernicke's aphasics, in accord with clinical observations. In addition, although Broca's aphasics produced both phonetic and phonemic errors, the results showed that they have a pervasive phonetic disorder which affects their correct target productions as well as the total number of phonetic errors produced. This deficit however seems to be a speech deficit rather than a low-level motor control problem. In contrast, the Wernicke's aphasics show a deficit characterized by isolated phonemic mistargeting errors. Finally, the pattern of productions for the Conduction aphasics indicates that some patients show a predominantly phonetic disorder similar to the Broca's aphasics and others show predominantly a phonemic disorder similar to the Wernicke's aphasics.     

The interrelationships and reliability of a multilevel behavior-based assessment package for distressed couples

Twenty-six couples interested in improving their marital relationships participated in a multi-level behavior based assessment battery. The measures included self-reported, self-monitored, and observed components, all of which were examined for their interrelationships. Test-retest reliability was carried out with six of the couples. Self-reported measures, self-monitored pleasing behaviors, observed positive nonverbal and some negative verbal interactions were found to be consistent. In general, the various levels of measurement were found to be significantly related to each other. Some of the findings were applied to coercion and reciprocity formulations of marital interactions.     

The role of imagery in the representation of linear orderings

Two experiments were carried out to investigate whether visual imagery was used in representing transitive linear ordering relationships. Subjects were presented with passages describing either a linear ordering or a set inclusion relationship, while being subjected to either visual or verbal interference. Performance was tested by asking subjects to judge the truth or falsity of statements concerning both the information presented in the passages and inferences that could be drawn from this information. In neither experiment was there any evidence for the linear ordering material being selectively disrupted by the visual interference task, as would have been predicted by the imagery theory. Thus it is concluded that linear orderings are probably not represented as visual images.     

Discrimination learning and stimulus generalization by impulsive and reflective children

The proposition that impulsive children inhibit expressive behavior less than reflective children was investigated by providing third grade impulsive and reflective boys with either differential or nondifferential forms or successive discrimination training prior to tests for stimulus generalization. Consistent with specific predictions derived from Spence's theory on the roles of excitation and inhibition, it was found that: (a) Reflectives acquired the discrimination more rapidly, (b) reflectives achieved a higher level of discriminative performance, (c) impulsives exhibited more variable response reates during the nonreinforced stimulus, and (d) the type of training interacted with the child's conceptual tempo to determine the elevation and shape of the post-discrimination generalization gradients. The results provide support for the construct validity of the Matching Familiar Figures Test of reflectivity-impulsivity.     

Lump detection in simulated human breasts

Sixteen observers palpated silicone models of human breasts containing lumps 1.6-12.1 mm in diameter. Detectability depended on the size of the lump, producing a systematic psychometric function. In eight observers who participated in three or more sessions, performance improved with practice, with most improvement occurring within one or two 26-trial sessions. Three-week retention measures disclosed no appreciable decrease in performance, but a significant correlation was found between the number of lumps detected and duration of trial (p < .01). There was no difference in performance between four observers who used their preferred hands and four observers who used their nonpreferred hands. These data establish that examination of breast models for the detection of lumps simulating cancer is a task amenable to experimental analysis.