ISLAM AND BIOETHICS

Muslim theologians, jurists, and healthcare workers have been addressing the challenges of modern biotechnology for years. Major textbooks on religion and bioethics cover Islam in one or two articles, offering only a general introduction to these important discussions. The five articles in this issue of the Journal of Religious Ethics, originating from a conference at Pennsylvania State University, are unusual in the specificity of their topics—brain death, feeding tubes, sex selection, spiritual counseling, and organ transplantation—and in their engagement with complex discussions in the Muslim and non‐Muslim worlds. In this essay, I introduce the five articles and consider two larger implications: the changing definition of the human person in light of biotechnological advances and the continuing importance of religious traditions, especially Islam, in legitimizing ethical responses to these advances.     

Anti-metaphysical reasoning and sociological approach: roads from nationalism to regionalism in the 19th–20th century Hungarian intellectual tradition

Some central issues of fin-de-siècle Hungarian philosophy and intellectual tradition can be retrieved from the writings of József Eötvös and his mid-nineteenth century contemporaries. An ambiguous attitude towards metaphysics, emphasis on sociological issues as well as a regional perspective are apparent in his texts prior to the emergence of the great fin-de-siècle generation of Hungarian intellectuals. They survived the Habsburg Empire thanks to the post-Monarchical literary tradition and Péter Esterházy’s works; they provided an adequate vocabulary for the Central European experience following the Soviet Era.     

The value of believing in free will: encouraging a belief in determinism increases cheating

Does moral behavior draw on a belief in free will? Two experiments examined whether inducing participants to believe that human behavior is predetermined would encourage cheating. In Experiment 1, participants read either text that encouraged a belief in determinism (i.e., that portrayed behavior as the consequence of environmental and genetic factors) or neutral text. Exposure to the deterministic message increased cheating on a task in which participants could passively allow a flawed computer program to reveal answers to mathematical problems that they had been instructed to solve themselves. Moreover, increased cheating behavior was mediated by decreased belief in free will. In Experiment 2, participants who read deterministic statements cheated by overpaying themselves for performance on a cognitive task; participants who read statements endorsing free will did not. These findings suggest that the debate over free will has societal, as well as scientific and theoretical, implications.     

The importance of knowledge in vivid text memory: An individual-differences investigation of recollection and familiarity

The goal of this study was to examine how individual variation in readers’ skills and, in particular, their background knowledge about a text are related to text memory. Recollection and familiarity estimates were obtained from remember and know judgments to text ideas. Recollection estimates to old items were predicted by readers’ background knowledge, but not by other comprehension-related factors, such as word-decoding skill and working memory capacity. False alarms involving recollection of new items (inferences) were diminished as a function of verbal ability, working memory capacity, and reasoning but increased as a function of background knowledge. The results suggest that recollection indexes the reader’s ability to construct a text representation in which text ideas are integrated with relevant domain knowledge. Moreover, these results highlight the importance of background knowledge in explaining individual variation in comprehension and memory for text.     

Assessing preference in elders with dementia using multimedia and verbal pleasant events schedules

The current study compared an abbreviated oral interview version of the Pleasant Events Schedule – Alzheimer's Disease (PES‐AD) to a multimedia‐supplemented version. Both measures identified multiple preferred items and their scores were moderately correlated (r = .481). Direct observations were conducted to determine whether either of the two measures predicted subsequent engagement. For all nine individuals with dementia, items endorsed as preferred by both versions of the PES‐AD resulted in high levels of engagement and items endorsed as non‐preferred items on both measures resulted in low to moderate levels of engagement. Individuals with MMSE scores of 10 or higher had more stable and differentiated patterns of engagement than individuals with scores below 10. For individuals with higher MMSE scores, items endorsed only by the multimedia version resulted in high engagement levels (i.e., true positive) while items endorsed only on the verbal presentation resulted in low levels (i.e., false positive). Copyright © 2008 John Wiley & Sons, Ltd.     

Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission

Memory persistence is a dynamic process involving the reconsolidation of memories after their reactivation. Reconsolidation impairments have been demonstrated for many types of memories in rats, and signaling at N-methyl-d-aspartate (NMDA) receptors appears often to be a critical pharmacological mechanism. Here we investigated the reconsolidation of appetitive pavlovian memories reinforced by natural rewards. In male Lister Hooded rats, systemic administration of the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo{a,d}cyclohepten-5,10-imine maleate (MK-801, 0.1 mg/kg i.p.) either before or immediately following a brief memory reactivation session abolished the subsequent acquisition of a new instrumental response with sucrose conditioned reinforcement. However, only when injected prior to memory reactivation was MK-801 effective in disrupting the maintenance of a previously-acquired instrumental response with conditioned reinforcement. These results demonstrate that NMDA receptor-mediated signaling is required for appetitive pavlovian memory reconsolidation.     

On the participation of mTOR in recognition memory

Evidence indicates that activation of the neuronal protein synthesis machinery is required in areas of the brain relevant to memory for consolidation and persistence of the mnemonic trace. Here, we report that inhibition of hippocampal mTOR, a protein kinase involved in the initiation of mRNA translation, immediately or 180min but not 540min after training impairs consolidation of long-term object recognition memory without affecting short-term memory retention or exploratory behavior. When infused into dorsal CA1 after long-term memory reactivation in the presence of familiar objects the mTOR inhibitor rapamycin (RAP) did not affect retention. However, when given immediately after exposing animals to a novel and a familiar object, RAP impaired memory for both of them. The amnesic effect of the post-retrieval administration of RAP was long-lasting, did not happen after exposure to two novel objects or following exploration of the training arena in the absence of other stimuli, suggesting that it was contingent with reactivation of the consolidated trace in the presence of a behaviorally relevant and novel cue. Our results indicate that mTOR activity is required in the dorsal hippocampus for consolidation of object recognition memory and suggest that inhibition of this kinase after memory retrieval in the presence of a particular set of cues hinders persistence of the original recognition memory trace.     

Cohort trends in perceived Internet influence on political efficacy in Hong Kong.

The study explored overall and cohort-specific trends in Internet political efficacy from an age-period-cohort approach with a cross-sequential design. Perceived Internet influence on political efficacy is found to increase with age. Significant difference between Internet users and nonusers is also found in some cohorts. Online news reading and online chats/discussions have a positive impact in some cohorts.     

Prediction of university students' academic achievement by linear and logistic models

University students' academic achievement measured by means of academic progress is modeled through linear and logistic regression, employing prior achievement and demographic factors as predictors. The main aim of the present paper is to compare results yielded by both statistical procedures, in order to identify the most suitable approach in terms of goodness of fit and predictive power. Grades awarded in basic scientific courses and demographic variables were entered into the models at the first step. Two hypotheses are proposed: (a) Grades in basic courses as well as demographic factors are directly related to academic progress, and (b) Logistic regression is more appropriate than linear regression due to its higher predictive power. Results partially confirm the first prediction, as grades are positively related to progress. However, not all demographic factors considered proved to be good predictors. With regard to the second hypothesis, logistic regression was shown to be a better approach than linear regression, yielding more stable estimates with regard to the presence of ill-fitting patterns.