Analyzing aphasia data in a multidimensional symptom space

The utility of single-case vs. group studies has been debated in neuropsychology for many years. The purpose of the present study is to illustrate an alternative approach to group studies of aphasia, in which the same symptom dimensions that are commonly used to assign patients to classical taxonomies (fluency, naming, repetition, and comprehension) are used as independent and continuous predictors in a multivariate design, without assigning patients to syndromes. One hundred twenty-six Italian-speaking patients with aphasia were first classified into seven classic aphasia categories, based on fluency, naming, auditory comprehension, and repetition scales. There were two goals: (1) compare group analyses based on aphasia types with multivariate analyses that sidestep classification and treat aphasic symptoms as continuous variables; (2) present correlation-based outlier analyses that can be used to identify individuals who occupy unusual positions in the multivariate "symptom space." In the service of the first goal, group performance on an external validation measure (the Token Test) was assessed in three steps: analyses of variance based on aphasia type, regressions using the same cut-offs for fluency, naming, comprehension and repetition as independent but dichotomous predictors, and regressions using the same subscales as continuous predictors (with no cut-offs). More variance in Token Test performance was accounted for when symptoms were treated as continuous predictors than with the other two methods, though use of independent but dichotomous predictors accounted for more variance than aphasia taxonomies. Thus, if we by-pass classical taxonomies and treat patients as points in a multidimensional symptom space, better predictions are obtained. Outlier analyses show that group results depend on heterogeneity among patients, which can be used as a search tool to identify potentially interesting dissociations. Hence this multivariate group approach is complementary to and compatible with single-case methods.     

Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice

Dopamine is critical for directing goal-oriented behavior. We investigated dopamine D₂ receptor involvement in reversal learning and reinforcement efficacy in mice lacking functional dopamine D₂ receptors and their heterozygous and wild-type littermates. Mice discriminated between two odors to receive a food reinforcer: One odor signaled a reinforcer (S⁺); the other odor signaled no reinforcer (S⁻). After mice learned the S⁺/S⁻ relationship, we inverted the reinforcement contingencies. The necessary number of trials to relearn the new reinforcement contingencies served as our index of reversal learning. Mice lacking functional dopamine D₂ receptors repeatedly failed to inhibit previously reinforced responses during reversal trials. In a separate experiment, mice responded for reinforcers on a progressive ratio schedule of reinforcement. Mice lacking functional dopamine D₂ receptors earned significantly fewer reinforcers than did heterozygous mice. Our results suggest that dopamine D₂ receptors regulate reversal learning and influence the reinforcing efficacy of natural rewards.     

Do behavioral disturbances in persons with Alzheimer's disease predict caregiver depression over time?

Random effects models were used to examine the association between behavioral disturbances in persons with Alzheimer's disease (N = 90) and caregiver depressive symptoms at 2-month intervals over an 18-month period. There was substantial variability in trajectories of change in caregiver depressive symptoms over time but no systematic increase in distress despite increased severity of dementia symptoms. Total behavioral disturbances were associated with higher levels of caregiver depressive symptoms: this effect was primarily attributable to aggressive behaviors. No consistent departure from linearity was evident in the relationship between behavior and depression over time.     

Levels of abstraction in orangutan (Pongo abelii) categorization

Levels of abstraction have rarely been manipulated in studies of natural concept formation in nonhumans. Isolated examples have indicated that animals, relative to humans, may learn concepts at varying levels of abstraction with differential ease. The ability of 6 orangutans (Pongo abelii) of various ages to make natural concept discriminations at 3 levels of abstraction was therefore investigated. The orangutans were rewarded for selecting photos of orangutans instead of humans and other primates (concrete level), primates instead of other animals (intermediate level), and animals instead of nonanimals (abstract level) in a 2-choice touch screen procedure. The results suggest that, like a gorilla (Gorilla gorilla gorilla) tested previously (Vonk & MacDonald, 2002), orangutans can learn concepts at each level of abstraction, and unlike other nonhumans, most of these subjects rapidly learned the intermediate level discrimination.     

Competition and recency in a hybrid network model of syntactic disambiguation

The competitive attachment model of human parsing is a hybrid connectionist architecture consisting of a distributed feature passing method for establishing syntactic relations within the network, and a numeric competition mechanism for resolving ambiguities, which applies to all syntactic relations. Because the approach employs a uniform mechanism for establishing syntactic relations, and a single competition mechanism for disambiguation, the model can capture general behaviors of the human parser that hold across a range of syntactic constructions. In particular, attachment and binding relations are similarly processed and are therefore subject to the very same influences of disambuguation and processing over time. An important influence on the competitive disambiguation process is distance within the network. Decay of numeric activation, along with distributed feature passing through the network structure, has an unavoidable effect on the outcome of attachment and binding competitions. Inherent properties of the model thus lead to a principled explanation of recency effects in the human parsing of both attachment and filler/gap ambiguities.     

Family management of childhood diabetes

This paper reviews the available literature on family management of childhood diabetes and highlights gaps in the current knowledge base. Four aspects of family management of childhood diabetes are discussed: coping (how the family adjusts to living with a child who has diabetes), compliance (how the family manages the child's diabetes on a daily basis), communication (how the family learns from interactions with the health provider), and context (how the family environment sets the stage for managing diabetes).     

Ending social encouters

Certain classes of verbal behavior—content summary statements (S_c); affective summary statements (S_a); continuity (C), justification (J), and well-wishing (W) statements; and statements of positive affect (P)—were hypothesized to be constituents of interpersonal endings. These statements are shown to increase during the terminal phase of a social encounter as a function of whether the conversation is between friends or strangers and whether it is structured or unstructured. A hypothesis concerning the sequence in which these five classes of statements will occur during the ending of an interaction, namely, [S_c] → [J] → [_Sa^P] → [C] → [W], is tested and confirmed.     

Why researchers don't study women: The responses of 62 researchers

Sixty-two researchers accounting for 64 single-sex studies that appeared in 1970 1971 issues of the Journal of Personality and Social Psychology reported why they had limited their studies to a single sex and why they had preferred either males or females for their studies. Also, articles and abstracts were read as a way of checking researchers' reporting practices. The replies were analyzed for thematic content and formed three major types: scientific (56%), practical (28%), and extrascientific (15%). The responses helped to explain why there has been an imbalance in psychology which led to the study of men rather than women instead of the exploration of both sexes. Sggestions are offered to help counteract this trend in future psychological research and reporting.