The utilization of genetic counselors within a newborn screening program

Genetic counselors have participated in the Michigan Newborn Screening Program on a contractual basis since 1988. Their role includes newborn screening education and training, newborn nursery site visits, and monitoring newborn screening in hospitals. Their impact has been to improve the quality of newborn screening services by reducing errors and increasing completion of data fields on newborn screening cards, improving hospital nursery cooperation and problem solving, and enhancing health department response to specific problems.     

Analysis of periodic data using Walsh functions

Data often contain periodic components plus random variability. Walsh analysis reveals periodicities by fitting rectangular functions to data. It is analogous to Fourier analysis, which represents data as sine and cosine functions. For many behavioral measures, Fourier transforms can produce spurious peaks in power spectra and fail to resolve separable components. Walsh analysis is superior for strongly discontinuous data. The strengths and weaknesses of each transform are discussed, and specific algorithms are given for the newer Walsh technique.     

Reflections on human pavlovian decelerative heart-rate conditioning with negative tilt as US: Alternative approaches

The negative-tilt preparation that has been reported since the late seventies is a specific form of Pavlovian conditioning that is of scientific interest and has potential applications. In this paper I reflect on the usefulness, to the development of this preparation, of two approaches to Pavlovian conditioning. One approach is the older S-R learning, stimulus-substitution paradigm exemplified by learning texts of the sixties. The other is the modern, Tolman-like view, according to which the phenomenon of Pavlovian conditioning is “now described as the learning of relations among events so as to allow the organism to represent its environment.” The three assumptions encapsulated by this approach are: (a) that only CS-US contingency relations are learned; (b) that teleological modes of explanations are adequate; (c) that the representational theory of knowledge is sound. Concerning Pavlovian conditioning in general, questions been raised in the literature for all three assumptions; they have not been adequately answered. Regarding the specific problem of developing the human Pavlovian heart-ratedecelerative conditioning with negative tilt as the US, I suggest that the cognitive approach has been much less helpful than the older, S-R, stimulus-substitution paradigm. Nevertheless, other literature clearly indicates that the cognitive, S-S approach has generated considerable interest and research, especially in preparations like the conditioned emotional response (CER), which are CS-IR ones in the sense that the effects on the CR are assessed indirectly through measuring an indicator or instrumental response (IR). Finally, even in CS-CR preparations like human GSR conditioning, it is important to study the cognitive, S-S learning process through using such dependent variables as continuously assessed subjective CS-US contingency.     

A flavor paired with lithium chloride blocks the formation of a pentobarbital-lithium chloride association

Thirsty rats were used in order to determine whether a vinegar solution, which had been paired with an injection of lithium chloride, could block the formation of an association between a pentobarbital- and a lithium chloride-induced state. During phase 1 the rats in the blocking group had a 2.0% vinegar solution paired with an injection of 240 mg/kg of lithium chloride, during phase 2 these rats were reexposed to the vinegar prior to each injection of 20 mg/kg of pentobarbital and 240 mg/kg of lithium chloride, and during phase 3 these rats were given access to a novel 0.75% saccharin solution and were injected with pentobarbital after saccharin removal. Animals with this history did not form an association between the pentobarbital- and lithium chloride-induced states during phase 2 as evidenced by their refusal to consume the saccharin solution over repeated pairings of saccharin with pentobarbital during phase 3. Control groups that received forward pairings of pentobarbital and lithium chloride, in the absence of a previously conditioned vinegar solution during phase 2, formed an association between pentobarbital and lithium chloride. These findings indicate that drug states and flavors can interfere with each others' capacity to predict the occurrence of lithium chloride.     

Sensible reasoning in two tasks: Rule discovery and hypothesis evaluation

The hypothesis testing skills of undergraduates were measured in two tasks: the 2-4-6 rule discovery task in which students generate and assess hypotheses, and a hypothesis evaluation task, which requires only the assessment of hypotheses. The results of Experiments 1 and 2 show that the students consistently employed a disconfirmation strategy when assessing hypotheses, but employed a counterfactual inference strategy when they also were required to generate the hypotheses. The results of Experiment 3 suggest that the selection of the hypothesis testing strategy reflected a balance between the logical requirements of the task and the desirability of possible outcomes. Taken together, the findings support a more consistent picture of human rationality across tasks, and suggest alternatives to accounts of confirmation bias.