The study of socioethical issues in systems biology

Systems biology is the rapidly growing and heavily funded successor science to genomics. Its mission is to integrate extensive bodies of molecular data into a detailed mathematical understanding of all life processes, with an ultimate view to their prediction and control. Despite its high profile and widespread practice, there has so far been almost no bioethical attention paid to systems biology and its potential social consequences. We outline some of systems biology's most important socioethical issues by contrasting the concept of systems as dynamic processes against the common static interpretation of genomes. New issues arise around systems biology's capacities for in silico testing, changing cultural understandings of life, synthetic biology, and commercialization. We advocate an interdisciplinary and interactive approach that integrates social and philosophical analysis and engages closely with the science. Overall, we argue that systems biology socioethics could stimulate new ways of thinking about socioethical studies of life sciences.     

The new experimental aesthetics—The beginning or the end?

In reference to recent work in aesthetics from a scientific perspective, Berlyne coined the phrase the new experimental aesthetics. Berlyne's contributions to this research area are discussed in terms of the philosophical, theoretical, and methodological issues central to the current literature. The paper concludes with a consideration of the future prospects for experimental aesthetics.This paper was presented at a symposium in honor of Daniel E. Berlyne at the annual meeting of the American Psychological Association, San Francisco, August 27, 1977. The presentation of this paper was supported by a grant from York University.     

The meaningful character of value-language: A critique of the linguistic foundations of emotivism

Conclusion The above arguments have not conclusively demonstrated the existence of value; nor have they sought to. Rather, they have focused primarily on value-language itself: what it is, what it means, and how men use it. In value-judgements, men intend to speak about reality, and not merely to manifest their feelings to influence others. The conceptual character of value-words gives them a formal objectivity lacking in mere manifestations of feeling; the meaning of value-words contains a claim to objectivity arising from the ontological claim to objectivity of value itself.These facts demonstrate conclusively that value-language differs essentially from emotive manifestations of feeling. Therefore, and in contradiction to both Ayer and Stevenson, even the most abstract of value-words can be used to form legitimate, conceptually meaningful value-judgements. As judgements, value-judgements can be true or false, not because of any factual content, but specifically as conceptually meaningful, pure value-judgements.I have deliberately restricted these investigations to consideration of language, without seriously arguing the ontology of value itself. Thereby, I have met the emotivists on their own ground. Even without demonstrating the existence of value, I have shown their analysis of value-language to be flawed. Further, I have identified a unique claim to objectivity in value-language which argues strongly in favor of the real existence of value as its ultimate foundation.For the simplest, most obvious explanation of this claim to objectivity is that it refers to value, which actually exists. That proof is logically the next step in my argument. A good place to begin would be a more careful, detailed analysis of the structure of human responses such as admiration, love, enthusiasm, etc., seeking to determine what they ontologically presuppose. Proof of the real existence of value would demonstrate the ontological grounds for the claim to objectivity of value-language. It would show that value-language is rooted in the real world, speaking of reality as it is. This would be the last, and most important sense in which value-language is meaningful and objective.

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Posthypnotic amnesia for recently learned material: Interactions with “episodic” and “semantic” memory

In two experiments, posthypnotic amnesia was suggested for a word list memorized during hypnosis. After an initial test of amnesia the subjects gave word associations (Experiment 1) or category instances (Experiment 2) to stimuli intended to elicit the critical (word list) items covered by the amnesia. The extent of initial amnesia observed was strongly associated with measured hypnotic susceptibility. Even among the most hypnotizable subjects, however, the dense amnesia did not prevent the critical items from being elicited by the semantic memory tasks, nor did it modulate the priming which these associations received by virtue of the prior learning experience. Moreover, production of the critical items did not, in general, remind the amnesic subjects of those items which they had previously learned, but could not now remember. Full memory was restored after the amnesia suggestion was canceled by a prearranged cue. Posthypnotic amnesia appears to represent a temporary dissociation of episodic features from memory traces, so that the subject has difficulty in reconstructing the context in which the target events occurred.     

Active and passive observers' attraction to a self-disclosing other

Active observer (participant) subjects were induced to make either a high or a low intimacy disclosure about themselves to a partner. Their (videotaped confederate) partner then disclosed either intimately or non-intimately in return. The impressions and attributions of these subjects were compared to the predictions of passive observer subjects (non-participants) who were each furnished with the original instructions, heard a tape recording of a different active observer's disclosure, and watched the same videotape of the confederate that person had seen. As expected, both active observers' responses and passive observers' predictions indicated a preference for the intimate partner. In addition, passive observers' attraction predictions were less positive than active observers' reports. But contrary to the hypotheses, passive observers predicted that active observers would attribute the partner's disclosure more to personalistic causes than was actually the case, and guessed inaccurately that active observers would interpret the partner's intimacy as an indicator of attraction. The methodological implications of these active-passive observer differences for research in self-disclosure and relationships are discussed.     

Overt expression of experimenter expectancies,interaction with subject expectancies,and performance on a psychomotor task

Subsequent to success or failure experience, 48 subjects attempted a psychomotor task in order to escape or avoid an aversive stimulus (tone). Their attempts at solving the task over 24 trials were made in the presence of subject-experimenters each of whom had expectancies instilled regarding the solution to the task. The job of the subject-experimenters was to “offer information” on every third trials as the subjects attempted to solve the task. It was hypothesized that the expectancies of the subject-experimenters would be communicated to the subjects via periodic comments, that these expectancies would differentially affect the subjects' performance on the task, and that prior experience on a similar task would differentially affect subjects' performances on the task. The results demonstrated that the expectancies instilled in the subject-experimenters were communicated and influenced the performances of subjects as predicted. It appears that consistency with respect to the expectancies communicated played a major role in producing significant effects. Prior experience failed to produce significant differences on task performance, a finding conflicting with that of D.S. Hiroto (Journal of Experimental Psychology, 1974, 102, 187–193). The results are discussed from the perspective of using the overt, explicit communication of expectancies as a means for exploring the illusive phenomenon of the experimenter expectancy effect.     

An investigation of the relationship between self-efficacy and the communication effectiveness of product manual formats

Product manuals have been virtually ignored in published research despite their relevance to consumer satisfaction and marketplace safety. This study examines self-efficacy (perceptions of capabilities related to operating a product) and how it influences the effectiveness of and is also influenced by three safety message formats commonly used in product manuals (i.e., 1. safety messages presented in list format at the front of the manual; 2; safety messages presented by semantic similarity interspersed throughout the manual—chunked format, and 3. safety messages presented in a combined format—both list and chunked). As anticipated, pre-exposure self-efficacy was a significant covariate which was found to be positively related to post-exposure self-efficacy and negatively related to information evaluation. Further, controlling for pre-exposure self-efficacy, post-exposure self-efficacy was significantly lower in the combined (list plus chunked) condition. Findings of this research have important implications for the practice of repeating safety warnings and future research in the consumer information domain.Authors are listed in alphabetical order. This study was supported by an Illinois State University Research Grant.     

Active control in interrupted dynamic spatial orientation: The detection of orientation change

Gibson (1966, 1979) suggested that an important property of perception is that the observer is active. Two experiments were conducted to examine the benefits of active observation in determining dynamic spatial orientation. Subjects were presented with displays simulating locomotion through a three-dimensional environment. Active observers continuously controlled locomotion, whereas passive observers viewed the display. During the trial, the display was blacked out for a brief period, followed by a static image that was at either the correct or the incorrect orientation following the blackout. Subjects were required to indicate whether they were positioned at the correct extrapolated orientation. The presence or absence of orientation change, the type of change (changes in rotation about the depth axis [roll], horizontal axis [pitch], or forward translation), the duration of the blackout, and the consistency of change were varied. In addition, the experiments used either a compensatory or a pursuit tracking task. Active observers had greater sensitivity than did passive observers in detecting a change for both tracking tasks. Subjects in both experiments exhibited greater sensitivity in detecting inconsistent changes (relative to consistent changes), suggesting that the dynamics specified by optical flow were incorporated in extrapolated orientation. In addition, sensitivity decreased with an increase in blackout duration. The results are discussed in terms of an extrapolation model of perception that incorporates the responses executed by active observers.     

Testing Two Theoretical Explanations for the Attraction-Enhancing Effects of Self-Disclosure

The study investigated the differential ability of similarity theory and social exchange theory to predict the effects of self-disclosure in a counseling versus a friendship encounter The participants were 80 undergraduates. A 2 (counseling or friendship) × 2 (positive or negative disclosure) × 2 (relevant or irrelevant disclosure) design was used in which participants rated the videotaped self-disclosure of an individual in an initial dyadic encounter. Unequivocal support was not obtained for either of the theories, but relationship context (counselor vs. peer) influenced the effects of disclosure as measured on counselor-peer and relationship characteristics. A unique feature of the study was the use of the Client Reactions System (CRS) to measure participants' immediate reactions to self-disclosure. The CRS demonstrated both relationship context and valence of disclosure (positive or negative) effects.