Multidisciplinary Engagement with Nanoethics Through Education—The Nanobio-RAISE Advanced Courses as a Case Study and Model

This paper presents and evaluates two advanced courses organised in Oxford as part of the European project Nanobio-RAISE and suggests using their format to encourage multidisciplinary engagement between nanoscientists and nanoethicists. Several nanoethicists have recently identified the need for ‘better’ ethics of emerging technologies, arguing that ethical reflection should become part and parcel of the research and development (R&D) process itself. Such new forms of ethical deliberation, it is argued, transcend traditional disciplinary boundaries and require the active engagement and involvement of both nanoethicists and nanoscientists with the broader issues surrounding technological developments. Whereas significant research efforts into multi- and interdisciplinary collaborations during R&D processes are now emerging, opportunities for encouraging multidisciplinary engagement through education have remained relatively underexplored. This paper argues that educational programmes could be a natural extension of ongoing collaborative research efforts ‘in the lab’ and analyses how the Nanobio-RAISE courses could be used as a model for course development. In addition to exploring how the elements that were conducive to multidisciplinary engagement in this course could be preserved in future courses, this paper suggests shifting the emphasis from public communication towards ethical deliberation. Further course work could thus build capacity among both nanoscientists and nanoethicists for doing ‘better’ nanoethics.     

Simulation à la Goldman: pretend and collapse

Theories of mind draw on processes that represent mental states and their computational connections; simulation, in addition, draws on processes that replicate (Heal 1986) a sequence of mental states. Moreover, mental simulation can be triggered by input from imagination instead of real perceptions. To avoid confusion between mental states concerning reality and those created in simulation, imagined contents must be quarantined. Goldman bypasses this problem by giving pretend states a special role to play in simulation (Goldman 2006). We argue that this path leads to the resurgence of the threat of collapse (Davies 1994), diluting the principled distinction between simulation and theory use. Exploration of a related method of real-mental states operating in a pretend mode leads to a factually untenable model. Our main goal here is to raise this problem as a challenge for Goldman’s reconfigured simulation theory. Only at the end we will briefly sketch a possible alternative way of quarantine that preserves the replicative element of simulation and avoids collapse. Figure 1 provides a guide to our argument. Fig. 1 Structure of argument

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Condorcet and communitarianism: Boghossian’s fallacious inference

This paper defends the communitarian account of meaning against Boghossian’s (Wittgensteinian) arguments. Boghossian argues that whilst such an account might be able to accommodate the infinitary characteristic of meaning, it cannot account for its normativity: he claims that, since the dispositions of a group must mirror those of its members, the former cannot be used to evaluate the latter. However, as this paper aims to make clear, this reasoning is fallacious. Modelling the issue with four (justifiable) assumptions, it shows that Condorcet’s ‘Jury Theorem’ can be used to prove that the dispositions of the majority of the members of a group can differ from those of any individual member in a way that makes it possible to use communal dispositions as a standard with which individual dispositions can be assessed. Moreover, the argument of the paper is also shown to have general implications for the use of formal methods in the explanation of the nature of certain fallacious inferences.     

Positive evidence for Eysenck’s arousal hypothesis: A combined EEG and MRI study with multiple measurement occasions

Eysenck’s arousal hypothesis suggests that introverts have greater cortical activity than extraverts. This prediction was tested in several studies that used the electroencephalogram (EEG) alpha activity to index cortical arousal, but empirical findings are inconsistent. Possibly, external factors of the measurement situation or static factors such as skull thickness may act as nuisance variables on alpha activity and thus mitigate the relation between arousal and extraversion. The aim of the present study was to test the arousal hypothesis with a focus on these methodological issues. Resting EEG was acquired on several occasions of measurement, skull thickness was quantified with anatomical magnetic resonance imaging (MRI), and extraversion was assessed by questionnaire. There was a positive association between alpha activity and extraversion, which was neither affected by external factors nor by skull thickness. This finding is in line with the arousal hypothesis and suggests that external or static factors do not contribute to the inconsistency of empirical findings.     

Cardiac modulation of startle: Effects on eye blink and higher cognitive processing

Cardiac cycle time has been shown to affect pre-attentive brainstem startle processes, such as the magnitude of acoustically evoked reflexive startle eye blinks. These effects were attributed to baro-afferent feedback mechanisms. However, it remains unclear whether cardiac cycle time plays a role in higher startle-related cognitive processes, as well. Twenty-five volunteers responded first by ’fast as possible’ button pushes (reaction time, RT), and second, rated perceived intensity of 60 acoustic startle stimuli (85, 95, or 105 dB; 50 ms duration; binaural; instantaneous rise time), which were presented either 230 or 530 ms after the R-wave, and eye blink responses were measured by EMG. RT was divided into evaluation and motor response time according to previous research. Increasing stimulus intensity enhanced startle eye blink, intensity ratings, and RT components. Eye blinks and intensity judgments were lower when startle was elicited at a latency of R + 230 ms, but RT components were differentially affected: the evaluative component was attenuated, and the motor component was accelerated when stimuli were presented 230 ms after the R-wave. We conclude that the cardiac cycle affects the attentive processing of acoustic startle stimuli.     

Speech‐perception‐in‐noise deficits in dyslexia

Speech perception deficits in developmental dyslexia were investigated in quiet and various noise conditions. Dyslexics exhibited clear speech perception deficits in noise but not in silence. Place‐of‐articulation was more affected than voicing or manner‐of‐articulation. Speech‐perception‐in‐noise deficits persisted when performance of dyslexics was compared to that of much younger children matched on reading age, underscoring the fundamental nature of speech‐perception‐in‐noise deficits. The deficits were not due to poor spectral or temporal resolution because dyslexics exhibited normal ‘masking release’ effects (i.e. better performance in fluctuating than in stationary noise). Moreover, speech‐perception‐in‐noise predicted significant unique variance in reading even after controlling for low‐level auditory, attentional, speech output, short‐term memory and phonological awareness processes. Finally, the presence of external noise did not seem to be a necessary condition for speech perception deficits to occur because similar deficits were obtained when speech was degraded by eliminating temporal fine‐structure cues without using external noise. In conclusion, the core deficit of dyslexics seems to be a lack of speech robustness in the presence of external or internal noise.     

Estimates of the Validity and Utility of the Conners’ Continuous Performance Test in the Assessment of Inattentive and/or Hyperactive-Impulsive Behaviors in Children

This study evaluated the validity and classification utility of the Conners' Continuous Performance Test (CCPT) in the assessment of inattentive and hyperactive-impulsive behaviors in children. Significant, positive correlations between the CCPT parameters and behavioral ratings of ADHD behaviors were hypothesized. In addition, it was hypothesized that the CCPT parameters would perform better than a random test (chance) and show fair to moderate utility of classification across the different indices. Participants were 104 children between 6 and 12 years of age who were referred for evaluation of attention problems. The first hypothesis was not supported. There were no significant, positive correlations between the CCPT parameters and parent and teacher ratings of inattentive and hyperactive-impulsive behaviors. The second hypothesis was only partially supported. The CCPT Overall Index and the Omission Errors (84th percentile cutoff) performed better than a random test; however, the utility of the CCPT Overall Index only ranged from poor to slight. Receiver operating characteristic analyses showed the accuracy of the CCPT to be low. The implications and limitations of this study and future research directions are discussed.     

Process Dissociation Procedure: Double Dissociations Following Divided Attention and Speeded Responding

The validity of the process dissociation procedure was examined by manipulating attention and speed of responding in a recognition task. Both manipulations were expected to decrease the probability of controlled memory processes, c, while leaving the probability of automatic memory processes, a, unaffected. In order to estimate c and a, a multinomial processing tree modelwas fittedto the data.Contrary to expectation, a double dissociation (i.e.a decrease inc coupled with an increase in a) was obtained, suggesting that a does not accurately measure the probability of automatic processes. The results are discussed with reference to the independence assumption in the process dissociation procedure.