Water temperature determines neurochemical and behavioural responses to forced swim stress: an in vivo microdialysis and biotelemetry study in rats

Forced swimming is a behavioural stress model increasingly used to investigate the neurocircuitry of stress responses. Although forced swim stress clearly is a psychological stressor (anxiety, panic), its physical aspects are often neglected. There are indications that behavioural and neurochemical responses to swim stress depend on the water temperature. Thus, we investigated the responsiveness of hippocampal serotonergic neurotransmission (important in the coordination of stress responses), and of behaviour and core body temperature to forced swimming at different water temperatures (19, 25 and 35 degrees C). In vivo microdialysis and biotelemetry in freely-behaving rats were used. Dialysates were analysed for serotonin (5-HT) and its metabolite 5-HIAA (5-hydroxyindoleacetic acid) by HPLC with electrochemical detection. Forced swimming in water at 25 and 19 degrees C decreased core body temperature by 8 and 12 degrees C, respectively. A rapid and pronounced increase in hippocampal 5-HT and 5-HIAA was found in rats that swam at 35 degrees C, whereas biphasic responses in 5-HT and 5-HIAA were observed at 25 and 19 degrees C. Also swim stress behaviour and post-stress home cage behaviour depended on the water temperature. Comparing the serotonergic and core body temperature changes revealed that a combination of two different 5-HT and 5-HIAA responses seems to shape the neurotransmitter response. Swimming-induced increases in hippocampal extracellular concentrations of 5-HT and 5-HIAA occurred at all water temperatures, but these increases were temporarily quenched, or concentrations were transistently decreased, when core body temperature fell below 31 degrees C in water at 25 or 19 degrees C. These data demonstrate that water temperature is a key factor determining the impact of forced swim stress on behaviour and neurochemistry, and underscore that changes in these parameters should be interpreted in the light of the autonomic responses induced by this stressor.     

Modular Treatment for Children and Adolescents With Problematic School Absenteeism: Development and Description of a Program in Germany

Problematic school absenteeism is defined as absence from school occurring with a clinical-level mental disorder. It represents a higher-order term for school refusal, school truancy, and the combination thereof and is associated with an increased risk for school dropout, prolonged mental disorders, and unemployment. This article describes the manualized modular treatment of problematic school absenteeism (MT) by a multiprofessional team. The manual was developed to target a broad spectrum of mental disorders characterized by internalizing but also externalizing behavior. The therapeutic focus is on the reintegration into school and on the cognitive behavioral treatment of the mental disorder. The MT is based on a multilevel model of problematic school absenteeism. The treatment is informed by an extensive case-conceptualization and addresses motivational aspects by offering a low-threshold therapeutic design and motivational interviewing. Core interventions are represented in four modules: cognitive behavioral therapy, family counseling, school counseling, and a psychoeducational physical exercise program. A case vignette provides an illustration of the treatment and the specific graduated approach for school reintegration. The current modular approach is discussed in relation to other cognitive-behavioral manuals targeting a broad spectrum of mental disorders or school refusal.     

How prioritized is self-prioritization during stimulus processing?

Recent research has suggested that self-relevance automatically enhances stimulus processing (i.e., the self-prioritization effect). Notably, information associated with one’s self elicits faster responses than comparable material associated with other targets (e.g., friend, stranger). Challenging the assertion that self-prioritization is an obligatory process, here we hypothesized that self-relevance only facilitates performance when task sets draw attention to previously formed target-object associations. The results of two experiments were consistent with this viewpoint. Compared with arbitrary objects owned by a friend, those owned by the self were classified more rapidly when participants were required to report either the owner or identity of the items (i.e., semantic task set). In contrast, self-relevance failed to facilitate performance when participants judged the orientation of the stimuli (i.e., perceptual task set). These findings demonstrate the conditional automaticity of self-prioritization during stimulus processing.     

Gaining control: training executive function and far transfer of the ability to resolve interference

Functional brain-imaging data document overlapping sites of activation in prefrontal cortex across memory tasks, suggesting that these tasks may share common executive components. We leveraged this evidence to develop a training regimen and a set of transfer tasks to examine the trainability of a putative executive-control process: interference resolution. Eight days of training on high-interference versions of three different working memory tasks increased the efficiency with which proactive interference was resolved on those particular tasks. Moreover, an improved ability to resolve interference was also transferred to different working memory, semantic memory, and episodic memory tasks, a demonstration of far-transfer effects from process-specific training. Participants trained with noninterference versions of the tasks did not exhibit transfer. We infer that the transfer we demonstrated resulted from increased efficiency of the interference-resolution process. Therefore, this aspect of executive control is plastic and adaptive, and can be improved by training.     

The role of orthography in speech production revisited

The language production system of literate adults comprises an orthographic system (used during written language production) and a phonological system (used during spoken language production). Recent psycholinguistic research has investigated possible influences of the orthographic system on the phonological system. This research has produced contrastive results, with some studies showing effects of orthography in the course of normal speech production while others failing to show such effects. In this article, we review the available evidence and consider possible explanations for the discrepancy. We then report two form-preparation experiments which aimed at testing for the effects of orthography in spoken word-production. Our results provide clear evidence that the orthographic properties of the words do not influence their spoken production in picture naming. We discuss this finding in relation to psycholinguistic and neuropsychological investigations of the relationship between written and spoken word-production.     

Bizarreness effects in verbal tasks and subject-performed tasks

Abstract

Recognition and cued recall of ordinary action phrases (e.g. “open the book”) and bizarre ones (e.g. “plant the hammer”) were compared under two encoding conditions: in verbal tasks (VTs), subjects learned the phrases by simply listening to them; in subject-performed tasks (SPTs), subjects learned the phrases by performing the denoted actions (without real objects). Memory performance was better after SPTs than after VTs in recognition and cued recall. In addition to this already established finding, it was observed that recognition was better for bizarre phrases than for ordinary ones after VTs and that bizarreness was unrelated to recognition after SPTs. Cued recall, on the other hand, depended on bizarreness after VTs as well as after SPTs and, in contrast to the recognition findings, ordinary phrases were recalled better than bizarre phrases. This pattern of findings was explained by the assumptions that lexical and conceptual information is encoded after VTs and motor information is additionally encoded after SPTs, and that different kinds of information are used in recognition and cued recall, and after VTs and SPTs.     

Levels-of-processing effects in subject-performed tasks

In memory for subject-performed tasks (SPTs), subjects encode a list of simple action phrases (e.g., thumb through a book, knock at the door) by performing these actions during learning. In three experiments, we investigated the size of the levels-of-processing effects in SPTs as compared with those in standard verbal learning tasks (VTs). Subjects under SPT and VT conditions learned lists of action phrases in a surface or a conceptual orienting task. Under both encoding conditions, the subjects recalled fewer items with surface orienting tasks than with conceptual orienting tasks, but the levels-of-processing effects were strongly reduced in the SPT condition. In the SPT condition, items that were encoded in a surface orienting task were still substantially recalled. The items were recalled almost as well as the conceptually encoded items in the VT condition. The distinct reduction of the levels-of-processing effect is caused by the fact that, in SPT encoding even with a verbal surface orienting task, subjects process conceptual information in order to perform the denoted action. We attribute the small conceptual advantage, which remains with SPT despite the conceptual processing for performing, to the fact that items are not as well integrated into memory as they are when conceptual processing is focused on the action component, rather than on the semantic contexts. This lower integration reduces the accessibility of items in the verbal surface task, even with SPT encoding.     

Re-Interpretation in Historiography: John Dewey and the Neo-Humanist Tradition

Did John Deweys new philosophy of education really try to dissolve the whole block of tradition or is his debt namely to educational core-concepts of neo-humanism deeper than he was prepared to acknowledge? After some general remarks on the process of reception as productive re-adaptation and its implication for historiography I will deal with Deweys own contexts that shape the interpretative grid through which he receives the tradition. Two case studies attempt to illustrate both continuity and discontinuity with a specific part of this tradition, namely two critical perspectives within German neo-humanism: Georg Wilhelm Friedrich Hegel and Johann Friedrich Herbart.     

The Paraphrase Argument Against Collective Actions

This paper is about the status of collective actions. According to one view, collective actions metaphysically reduce to individual actions because sentences about collective actions are merely a shorthand for sentences about individual actions. I reconstruct an argument for this view and show via counterexamples that it is not sound. The argument relies on a paraphrase procedure to unpack alleged shorthand sentences about collective actions into sentences about individual actions. I argue that the best paraphrase procedure that has been put forward so far fails to produce adequate results.