C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects

Cortisol affects the acute-phase response, but it is unknown whether C-reactive protein (CRP), an acute-phase reactant, also affects hypothalamus?pituitary?adrenal axis activity. In the present study, associations were explored between CRP haplotypes with plasma CRP concentrations and basal salivary cortisol level. We included 266 physically healthy Caucasian subjects (103 females and 163 males) aged between 18 and 65 years of whom 94 had a psychiatric disorder in a genetic association study. Six tag single-nucleotide polymorphisms capturing the common genetic variation of the CRP gene were genotyped (i.e. rs2808628, rs2808630, rs1205, rs1800947, rs1417938, and rs3091244) to yield common CRP haplotypes. Plasma CRP concentrations, the salivary cortisol awakening response (CAR) (0, 30, 45, and 60?min after awakening), and the diurnal cortisol decline (11:00, 15:00, 19:00, and 23:00 h) were assessed for 2 days. rs2808628, rs1205, rs1417938, and rs3091244 showed expected associations not only with CRP concentrations, but also with salivary cortisol levels during the CAR. Five well-characterized CRP haplotypes were arranged in ascending order according to increasing CRP levels. There was an inverse linear association between CRP haplotypes and cortisol levels during the CAR, but no association with the diurnal cortisol decline. Hence, genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions.     

The role of testosterone in social interaction

Although animal researchers established the role of testosterone as a 'social hormone' decades ago, the investigation of its causal influence on human social behaviors has only recently begun. Here, we review and discuss recent studies showing the causal effects of testosterone on social interactions in animals and humans, and outline the basic neurobiological mechanisms that might underlie these effects. Based on these recent findings, we argue that the role of testosterone in human social behavior might be best understood in terms of the search for, and maintenance of, social status.     

On the control of visual fixation durations in free viewing of complex images

The mechanisms for the substantial variation in the durations of visual fixations in scene perception are not yet well understood. During free viewing of paintings, gaze-contingent irrelevant distractors (Exp. 1) and non-gaze-related time-locked display changes (Exp. 2) were presented. We demonstrated that any visual change-its onset and offset-prolongs the ongoing fixation (i.e., delays the following saccade), strongly suggesting that fixation durations are under the direct control of the stimulus information. The strongest influence of distraction was observed for fixations preceded by saccades within the parafoveal range (<5° of visual angle). We assume that these fixations contribute to the focal in contrast to the ambient mode of attention (Pannasch & Velichkovsky, Visual Cognition, 17, 1109-1131, 2009; Velichkovsky, Memory, 10, 405-419, 2002). Recent findings about two distinct "subpopulations of fixations," one under the direct and another under the indirect control of stimulation (e.g., Henderson & Smith, Visual Cognition, 17, 1055-1082, 2009), are reconsidered in view of these results.     

Disengagement in work‐role transitions

The present study examines whether disengagement from previous work‐roles positively predicts adaptation to a new work‐role (here, becoming self‐employed) by reducing negative consequences of psychological attachment to these previous roles. Disengagement involves an individual's effort to release attention from thoughts and behaviours related to the previous work‐role. A three‐wave longitudinal study investigated the relationship between psychological attachment (measured as affective commitment) to a prior work‐role, disengagement from the prior work‐role, and adaptation to a new work‐role [pursuit of learning, fit perceptions with self‐employment, task performance over time]. Participants included 131 persons who recently founded a small business. Results indicated that psychological attachment to the past work‐role was negatively related to pursuit of learning and fit with the new work‐role. Disengagement from the past work‐role was positively related to pursuit of learning in the new work‐role, and buffered the negative relationship between psychological attachment and fit as well as task performance.     

Open-source software to conduct online rating studies

Several software programs exist to assist researchers in setting up online questionnaires. Existing tools are of little help for delivering online rating studies, for which it is often desirable to collect data from participants for only a subset of a stimulus set. OR-Vis enables researchers to quickly set up online rating studies by supplying the set of items to be rated, the number of stimuli an individual participant responds to, the number of participants an item is shown to, and the rating questions. The software then generates and delivers unique questionnaires for each participant, while managing the data collection process. The present article describes OR-Vis, its installation process, and how to use it to gather data. OR-Vis is open-source software and can be downloaded from www.orvis.uni-muenster.de.     

Die Entwicklung der Rechtsprechung zur nachträglichen Sicherungsverwahrung seit 2006

Since 2006, the development of the jurisdiction concerning the subsequent preventive detention has kept the continuity of the first decisions by the German Federal Supreme Court. An imprisonment according to the new law standards was decreed only in a few cases. The legislator’s attempts to enlarge its use by introduction of § 66b I 2 German penal code in substance were ineffective, because both the German Federal Supreme Court and the Federal Constitutional Court has viewed the law as constitutional, only, if its use is limited to a few “extreme cases”. Further difficulties appeared by the injunction of the subsequent preventive detention due to an acquittal statement of a hospital order treatment. At this some questions still remain unanswered.     

Sunscreens with Titanium Dioxide (TiO<Subscript>2</Subscript>) Nano-Particles: A Societal Experiment

The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of sunscreens containing nano-sized titanium dioxide (TiO₂) particles. We argue that the marketing of this TiO₂ nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation). To remedy the current way nano-sized TiO₂ containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing review, designing for safety, and regulative improvements) so that its marketing can become more acceptable.     

Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease

The Clock Drawing Test (CDT) is a widely used instrument in the neuropsychological assessment of Alzheimer's disease (AD). As CDT performance necessitates several cognitive functions (e.g., visuospatial and constructional abilities, executive functioning), an interaction of multiple brain regions is likely. Fifty-one subjects with mild cognitive impairment, 23 with AD and 15 healthy controls underwent high-resolution magnetic resonance imaging. Optimized voxel-based morphometry (VBM) was performed to investigate the putative association between CDT performance and gray matter (GM) density throughout the entire brain. In the first step of analysis (p<.001, uncorrected), VBM revealed a reduced GM density in numerous cortical (temporal lobe, frontal lobe, parietal lobe, cerebellum) and subcortical (thalamus, basal ganglia) brain regions to be associated with poorer CDT performance. When corrected for multiple comparisons (p<.01), the associations remained significant predominantly in the left temporal and--less pronounced--the right temporal lobe. VBM demonstrated CDT performance to depend on the integrity of widely distributed cortical and subcortical areas in both brain hemispheres with accentuation in the left-sided temporal lobe region.     

When positive and negative expectancies disrupt performance: regulatory focus as a catalyst

The present research investigates the impact of negative and positive stereotypic expectancies on cognitive test performance. A theoretical framework that relates expectancy effects to self‐regulatory processes as postulated by Regulatory Focus Theory (RFT) is presented. Building on the differential sensitivity hypothesis proposed in this theoretical model, we argue that when self‐regulation in a prevention focus is activated individuals are particularly sensitive with regard to negative cues and therefore negative expectancies are likely to result in poor test performance due to an apprehension about meeting minimal goal standards. Conversely, when self‐regulation is guided by a promotion focus individuals are particularly sensitive with regard to positive cues and hence likely to show impaired performance when confronted with positive expectancies due to an apprehension about meeting maximal goal standards. The results of four experiments, relying on both situational and chronic regulatory focus, support these assumptions. Copyright © 2007 John Wiley & Sons, Ltd.     

Prevention-focused self-regulation and aggressiveness

The present research examined the relationship between individual differences in self-regulatory mechanisms as outlined in regulatory focus theory (promotion- and prevention-focused self-regulation) and aggressiveness. Two studies revealed that the more individuals’ habitual self-regulatory orientation is dominated by a prevention-focus, the more likely they are to score high on measures of cynical hostility, reciprocity norm endorsement, and aggressiveness. An additional study involving the manipulation of perceived violation of a reciprocity norm showed that predominantly prevention-focused participants were particularly sensitive to the experience of a norm violation and reacted in a hostile and aggressive manner following the norm violation experience. Findings indicate that a prevention-focused style of self-regulation is associated with aggressiveness and suggest that endorsement of (negative) reciprocity norms and sensitivity to norm violations are relevant factors that help explain the differences in aggressiveness observed among individuals with a predominantly prevention-focused style of self-regulation.