Sunscreens with Titanium Dioxide (TiO<Subscript>2</Subscript>) Nano-Particles: A Societal Experiment

The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of sunscreens containing nano-sized titanium dioxide (TiO₂) particles. We argue that the marketing of this TiO₂ nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation). To remedy the current way nano-sized TiO₂ containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing review, designing for safety, and regulative improvements) so that its marketing can become more acceptable.     

Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease

The Clock Drawing Test (CDT) is a widely used instrument in the neuropsychological assessment of Alzheimer's disease (AD). As CDT performance necessitates several cognitive functions (e.g., visuospatial and constructional abilities, executive functioning), an interaction of multiple brain regions is likely. Fifty-one subjects with mild cognitive impairment, 23 with AD and 15 healthy controls underwent high-resolution magnetic resonance imaging. Optimized voxel-based morphometry (VBM) was performed to investigate the putative association between CDT performance and gray matter (GM) density throughout the entire brain. In the first step of analysis (p<.001, uncorrected), VBM revealed a reduced GM density in numerous cortical (temporal lobe, frontal lobe, parietal lobe, cerebellum) and subcortical (thalamus, basal ganglia) brain regions to be associated with poorer CDT performance. When corrected for multiple comparisons (p<.01), the associations remained significant predominantly in the left temporal and--less pronounced--the right temporal lobe. VBM demonstrated CDT performance to depend on the integrity of widely distributed cortical and subcortical areas in both brain hemispheres with accentuation in the left-sided temporal lobe region.     

When positive and negative expectancies disrupt performance: regulatory focus as a catalyst

The present research investigates the impact of negative and positive stereotypic expectancies on cognitive test performance. A theoretical framework that relates expectancy effects to self‐regulatory processes as postulated by Regulatory Focus Theory (RFT) is presented. Building on the differential sensitivity hypothesis proposed in this theoretical model, we argue that when self‐regulation in a prevention focus is activated individuals are particularly sensitive with regard to negative cues and therefore negative expectancies are likely to result in poor test performance due to an apprehension about meeting minimal goal standards. Conversely, when self‐regulation is guided by a promotion focus individuals are particularly sensitive with regard to positive cues and hence likely to show impaired performance when confronted with positive expectancies due to an apprehension about meeting maximal goal standards. The results of four experiments, relying on both situational and chronic regulatory focus, support these assumptions. Copyright © 2007 John Wiley & Sons, Ltd.     

Prevention-focused self-regulation and aggressiveness

The present research examined the relationship between individual differences in self-regulatory mechanisms as outlined in regulatory focus theory (promotion- and prevention-focused self-regulation) and aggressiveness. Two studies revealed that the more individuals’ habitual self-regulatory orientation is dominated by a prevention-focus, the more likely they are to score high on measures of cynical hostility, reciprocity norm endorsement, and aggressiveness. An additional study involving the manipulation of perceived violation of a reciprocity norm showed that predominantly prevention-focused participants were particularly sensitive to the experience of a norm violation and reacted in a hostile and aggressive manner following the norm violation experience. Findings indicate that a prevention-focused style of self-regulation is associated with aggressiveness and suggest that endorsement of (negative) reciprocity norms and sensitivity to norm violations are relevant factors that help explain the differences in aggressiveness observed among individuals with a predominantly prevention-focused style of self-regulation.     

Sexuell übergriffiges und aggressives Verhalten im Kindesalter Einflüsse entwicklungsrelevanter Faktoren

During the last years increasing attention has been paid to young children and adolescents with sexual coercive behaviour. During the year 2007 altogether 232 boys and 30 girls under the age of 14 years were reported to the police because of sexual assaults. In NRW an increasing number of in- and out-patient institutions offers specific and unspecific treatment programs for these children. The major aim of our study, which is supported by the Ministry of Employment, Health and Social Affairs of the state of NRW, is to evaluate the wide range of different treatment programs and to find predictors for successful or difficult treatment outcomes. Furthermore we are interested in differences between children with sexual problem behaviour and children with exclusively aggressive problems. So far 23 institutions take part in our research project and our total sample currently consists of 75 boys between 9 - 15 years. A psychometric test battery is applied at the beginning of individual treatment. Our first results highlight differences in socio-demographic data between children with sexual coercive behaviour and children with exclusively aggressive behaviour problems. Compared to children with exclusively aggressive problem behaviour, children with sexual problem behaviour come more often from incomplete families with no male parent, have experienced more psychological and physical violence and have been more often victims of sexual abuse. Compared to children with exclusively aggressive behaviour problems they score significantly higher on the “Depression / Anxiety” scale of the SPS-J, although average T-scores for both groups are within the normal range. Regarding cognitive functioning there are no significant differences between both groups.     

The moderator effect that wasn't there: statistical problems in ambivalence research

Ambivalence researchers often collapse separate measures of positivity and negativity into a single numerical index of ambivalence and refer to it as objective, operative, or potential ambivalence. The authors argue that this univariate approach to ambivalence models undermines the validity of subsequent statistical analyses because it confounds the effects of the index and its components. To remedy this situation, they demonstrate how the assumptions underlying the indices derived from the conflicting reactions model and similarity-intensity model can be tested using a multivariate approach to ambivalence models. On the basis of computer simulations and reanalyses of published moderator effects, the authors show that the frequently reported moderating influence of ambivalence on attitude effects may be a statistical artifact resulting from unmodeled correlations of positivity and negativity with attitude and the dependent variable. On the basis of extensive power analyses, they conclude that it may be extremely difficult to detect moderator effects of ambivalence in observational data. Therefore, they encourage ambivalence researchers to take an experimental approach to study design and a multivariate approach to data analysis.     

Locus of control and the flow experience: An experimental analysis

The present research addresses the notion that the compatibility of skills and task demands involved in a given activity elicits a flow experience that renders the respective activity rewarding. The study employed an experimental paradigm to document the causal impact of skills–demands compatibility on the emergence of flow and revealed that participants characterized by a strong internal locus of control (LOC) were most sensitive to the manipulation of skills–demands compatibility and experienced flow under conditions of a fit of skills and task demands, whereas individuals with a weak internal LOC did not enter the state of flow. In line with previous findings, this suggests that distinct personality attributes are of critical relevance for the experience of flow to emerge. Copyright © 2008 John Wiley & Sons, Ltd.     

Differences in perceptions on sexual and reproductive health between service providers and people living with HIV: a qualitative elicitation study

The sexual and reproductive health (SRH)-related needs of people living with HIV/AIDS (PLHA) have not been sufficiently recognised in research and clinical care. Fifteen study sites in 13 European countries participated in this qualitative study to assess differences in perceptions between service providers (SP) and PLHA on SRH-related problems and needs of PLHA. Factors influencing SRH were determined to collect evidence on how to improve service provision. Qualitative data were obtained using an interpretative ethnographical approach. Data were analysed inductively on country level; a cross country data matrix was developed to facilitate the contextual analysis. Thirty-seven FGD discussions were organised with a total of 254 participants. A short survey was distributed to assess demographic characteristics. Results revealed insufficient information and lack of behavioural skills regarding SRH issues among PLHA. Intra- and interpersonal, provider-related, and social factors were found to influence the SRH behaviours of PLHA. Although from patients' perception SRH is a prioritized issue, it rarely comes up during routine HIV clinical care. SP need adequate counseling training to tackle SRH-related issues. A better integration between HIV care programs and SRH care settings is needed to improve effective service provision.     

Out of the Clash of Hermeneutic Rules Comes Ethical Decision Making: But Does it?

IRBs and REBs use specialized language. A process of definition and re-definition of the situation occurs. That process of interpretation can usefully be considered from the perspective of interpretive social science models involving Symbolic Interaction, Semiotics and Hermeneutics. Seven examples are provided to flesh out the nuances of contextual decision making and the “casuistic” aspects of a balanced approach to complex problems. While many decisions are relatively unproblematic and can follow a template, it is not possible simply to apply a fixed and mechanical approach. Hence, a socialization process occurs in which committee members must learn the actual application of the rules as opposed to the formal requirements. A “tightrope” between overly rigid and overly lax interpretations must be crossed and the more we understand the process of semiosis and the semiotic context the more likely it will be that truly ethical decisions will be “accomplished.” The lack of adequate survey data makes it all the more important to have good theoretical understanding of process.