Whose Gene Is It? A Case Discussion About Familial Conflict over Genetic Testing for Breast Cancer

A multidisciplinary group of genetic and other professionals discuss a complex case of familial conflict over access to genetic information. One twin wishes to know the results of her deceased mother's tests for BRCA1 mutations; a second twin objects to researchers making this information available. As the case discussion unfolds, the apparent facts of this case are called into question and the lines of ethical certainty become less clear.     

Reversal of Relative Thresholds for Synaptic Facilitation and Increased Excitability Induced by Serotonin and Tail Nerve Stimulation inAplysiaSensory Neurons

Tail shock induces reflex sensitization inAplysiaand, in parallel, induces a number of modulatory effects in central neurons, such as increased excitability in tail sensory neurons (SNs) and facilitation of synaptic transmission from SNs to motor neurons. Both of these modulatory effects are mimicked by exogenous application of serotonin (5HT) or electrical stimulation of the tail nerve P9. In the present study we examined the activation thresholds for increased excitability and synaptic facilitation induced by either 5HT or P9 stimulation. We found that the concentration of 5HT sufficient to produce a significant increase in excitability produced no significant synaptic facilitation and, conversely, that the intensity of nerve stimulation sufficient to produce significant synaptic facilitation produced no excitability changes. This reversal of relative thresholds for these modulatory effects may reflect the differential access of exogenous 5HT and endogenous 5HT (released by tail nerve stimulation) to the SN cell body and synaptic terminals, respectively.     

Isoluminance and contingent color aftereffects

In the typical induction of the orientation-contingent color aftereffect (CCAE), the stimuli are composed of elements that differ in both color and luminance. Three experiments are reported that show that chromatic contrast between stimulus elements is insufficient for the induction of the orientation-CCAE and that luminance contrast is necessary. These experiments expand on previous research concerned with the role of luminance contrast in the induction of orientation-CCAEs by eliminating alternative explanations.     

Causal Attributions for Poorly Performing Projects: Their Effect on Project Continuation Decisions

This study examined the escalation problem within an attribution theory framework. Students read a case scenario containing causal attribution information that described a poorly performing project under their supervision. They made estimates of its future success, as well as a decision whether to continue it. Perceived stability of causality had the primary effect on expectancy of success. A project whose performance downturn was attributed to a stable cause had a lower expectancy. Locus of causality had a smaller but still significant effect. Project downturns attributed to internal causes had a lower expectancy. Expectancy of success was significantly correlated with project continuation decisions. Discrepancies between these results and those reported by Staw and Ross (1978) are accounted for in terms of Weiner's (1985, 1986) attributional analysis.     

Politeness and memory for the wording of remarks

Three experiments were conducted to examine whether people spontaneously remember the wording used to convey politeness. In all experiments, subjects heard statements varying in politeness that had been made by either a high-status (e.g., a professor) or equal-status (e.g., another student) speaker. Subjects’ incidental memory for these statements was then tested with either a recognition (Experiments 1 and 3) or a recall (Experiment 2) procedure. As expected, there was evidence of significant memory for wording that conveyed politeness, and subjects were more likely to remember forms that were incongruous with the speaker’s status. There was also some evidence that subjects encoded the politeness of a remark even when they were unable to recall the specific remark. The results demonstrate the role of the interpersonal dimension in the processing of language in context.     

End-Weight from the Speaker's Perspective

Explanations of the tendency to put long, complex constituents at the ends of sentences (end-weight) usually take the listener's perspective, claiming it facilitates parsing. I argue for a speaker-oriented explanation of end-weight, based on how it facilitates utterance planning. Parsing is facilitated when as much tree structure as possible can be determined early in the string, but production is easiest when options for how to continue are kept open. That is, listeners should prefer early commitment and speakers should prefer late commitment. Corpus data show that different verbs exhibit different rates of word-order variation that are systematically related to differences in subcategorization possibilities in just the way predicted by a strategy of late commitment. Thus, a speaker-based account of lexical preferences in word ordering does a better job of explaining variation in weight effects than a listener-based account.     

Finding the Locus of Semantic Satiation: An Electrophysiological Attempt

The present study examined the effect of massed repetition of an initial category name upon the subsequent semantic categorization of a target word by means of an electrophysiological measure of semantic processing: the N400. Results showed the classic N400 effect, whereby evoked potentials were more negative for targets that were not members of the repeated category than for member targets. Moreover, repetition of the category name led to an increased and sustained positivity. The N400 effect was not modified, however, by repetition. Hence, insomuch as the N400 reflects meaning integration processes, these results do not support the hypothesis that massed repetition exerts its influence at the level of meaning integration.     

Is it emotion or is it stress? Gender stereotypes and the perception of subjective experience

Two studies of college undergraduates (ns = 95 and 92, primarily non-Hispanic whites and Asian Americans) investigated gender stereotypes of stress and emotion, as well as variables that influence the perception of gender-related differences. Study 1 assessed how gender stereotypes differ from the self-reports of men and women. When asked to choose a label for the subjective experience of the average man and the average woman in a series of problematic hypothetical situations, participants generally tended to believe that the average female would feel ‘emotional,” but that the average male would feel “stressed.” By contrast, the label participants chose to describe their own subjective experience was not significantly affected by their gender. In addition, participants believed the average woman and man differed more in the intensity of their emotions than in the intensity of their stress, a belief contradicted by their own self-reports. Results of Study 2 indicated that gender-related differences in estimations of stress and emotion for the self were reduced or eliminated when specific information about experience-eliciting situations was provided. We would like to thank Matthew Dank for his help in preparing the stimulus materials.     

Deconstructing Dispositional Bias in Clinical Inference: Two Interventions

In this study, the authors examined the effectiveness of instruction in attribution processes and practice in empathic perspective taking in deconstructing dispositional bias of counselor trainees. Videotaped stimulus cases and a clinical attribution scale were used to assess the treatment effects when compared with a placebo control condition. Results revealed significant differences among groups. Counselor trainees receiving either of the 2 interventions showed significantly lower dispositional bias in responding to videotaped clinical cases than did their counterparts in the placebo condition. The study points to a need for a paradigm shift from a person-focused to a system-focused approach in counseling practice. Implications also point to the need for including critical thinking and empathic experiencing in clinical training     

Evolutionary skepticism

International Journal for Philosophy of Religion -