Disease Rarity,Carrier Status,and Gender: A Triple Disadvantage for Women with Fabry Disease

Fabry disease is a multi-systemic X-linked genetic disorder which has progressive and deadly consequences for those it afflicts. Fabry disease symptoms are widely recognized as a substantive burden for affected males. In comparison, female heterozygotes have traditionally been viewed as relatively symptom-free, though a debate continues about whether and how much they suffer with the disease. Previous research suggests that females with Fabry disease may be triply disadvantaged in healthcare settings owing to: (1) disease rarity, (2) devalued carrier status, and (3) gender. The combined effects of these three factors suggest that female heterozygotes may suffer substantially with Fabry disease symptoms. A qualitative analysis of a brief disease-specific questionnaire provides supportive evidence. The female Fabry disease participants described experiencing significant symptoms that interfered with their lives. They also described unsatisfying experiences with healthcare professionals related to disease rarity, carrier status, and gender. The results of this study corroborate the suggestion that this triple disadvantage exists and may preclude appropriate management and treatment of females with Fabry disease. The role of healthcare professionals, including genetic counselors, in remedying this disadvantage is reviewed.     

Logical constructivism,modal logic,and metaphysics: a reply to Professor Pruss' ``Professor Lucas' second epistemic way'

International Journal for Philosophy of Religion -     

Seeing power in action: The roles of deliberation, implementation, and action in inferences of power

Six experiments investigate the hypothesis that social targets who display a greater action orientation are perceived as having more power (i.e., more control, less dependence, and more influence) than less action-oriented targets. I find evidence that this inference pattern is based on the pervasive belief that individuals with more power experience less constraint and have a greater capacity to act according to their own volition. Observers infer that targets have more power and influence when they exhibit more implementation than deliberation in the process of making decisions in their personal lives (Study 1a), in a public policy context (Study 1b), and in small groups (Study 2). In an organizational context, observers infer that a target who votes for a policy to change from the status quo has more power than a target who votes not to change from the status quo (Study 3). People also infer greater intra-organizational power and higher hierarchical rank in targets who take physical action toward a personal goal than in those who do not (Studies 4-5).     

Development and validation of a Client Problem Profile and Index for drug treatment

The development of the Client Problem Profile and Index are described, and initial concurrent and predictive validity data are presented for a sample of 547 patients in outpatient methadone treatment. Derived from the TCU Brief Intake for drug treatment admissions, the profile covers 14 problem areas related to drug use (particularly cocaine, heroin/opiate, marijuana, other illegal drugs, and multiple drug use), HIV risks, psychosocial-functioning, health, employment, and criminality. Analyses of predictive validity show the profile and its index (number of problem areas) were significantly related to therapeutic engagement, during-treatment performance, and posttreatment follow-up outcomes. Low moderate to high moderate effect sizes were observed in analyses of the index's discrimination.     

Thinking Out Loud about Teaching Bioethics: A Contribution from the Edge

Abstract. Teaching bioethics might be likened to a rollercoaster ride of twists, turns, and dips that invite teachers and students to experience something of their own edges of fear and comfort. Here the author provides readers with a glimpse into her distinctive approach to teaching bioethics that encourages students to move beyond boundaries of personal comfort zones by willfully transgressing traditional or comfortable boundaries. The essay describes how this is accomplished through a variety of methods – provocative readings, classroom discussion, student response papers, and student ethics committees. The author contends that teaching bioethics ought to include critical pedagogical methods and an alertness for real‐life intersections of science and ethics. Teaching bioethics can be a subversive activity that encourages students and teachers to engage in making life morally livable.     

Is An Agreement An Exchange of Intentions?

Abstract: Margaret Gilbert has argued that an agreement is not exchange of promises, since no such exchange plays all the roles she claims are distinctive of agreements. After briefly discussing the notion of intention and the principles governing intentions, I argue that a certain type of exchange of intentions – in which one person forms a conditional intention to act if the other does, and the other forms an unconditional intention to act on the presumption that the first will do what they have said – plays all these roles, and so conclude that an agreement is in fact an exchange of intentions.     

Just how controversial is evidential holism?

This paper is an examination of evidential holism, a prominent position in epistemology and the philosophy of science which claims that experiments only ever confirm or refute entire theories. The position is historically associated with W.V. Quine, and it is at once both popular and notorious, as well as being largely under-described. But even though there’s no univocal statement of what holism is or what it does, philosophers have nevertheless made substantial assumptions about its content and its truth. Moreover they have drawn controversial and important conclusions from these assumptions. In this paper I distinguish three types of evidential holism and argue that the most oft-cited and controversial thesis is entirely unmotivated. The other two theses are much overlooked, but are well-motivated and free from controversial implications.