Olfaction in Persons with Alzheimer's Disease

The need for low cost, noninvasive procedures for aiding in the diagnosis and understanding of Alzheimer's Disease (AD) has led to theories and procedures examining the role of olfactory disorders because of the finding that the brains of AD patients invariably exhibit neuropathology hi the hippocampus and entorhinal cortex. This loss correlates with the increase in the number of plaques and tangles and with the severity of dementia. Considered together, these findings suggest that brain structures closely related to the olfactory system demonstrate significant histopathology in AD. A comprehensive review of the literature pertaining to olfaction in persons with AD revealed that the olfactory identification ability of patients with memory disorders is impaired relative to controls. Consistency is lacking, however, when olfactory detection thresholds are investigated. Also, there is inconsistency in regards to severity of illness and olfactory function. In addition to differentiating AD patients from normals, the olfactory paradigm has shown some limited usefulness in differentiating AD patients from some other demented patients.     

Psychological adjustment of pediatric lung transplantation candidates and their parents

Investigated psychological functioning of 45 children and adolescents (ages 5 to 17 years) and their parents presenting at a major medical center for evaluation for lung transplantation. Patients completed self-reports, and parents completed measures on their children's behavior problems and emotional distress as well as on their own symptoms of distress. In general, children and their parents reported normal functioning on standard psychological measures. Few children fell in the clinically significant range, whereas 21% of mothers and 14% of fathers reported clinically significant levels of distress. Older children reported lower levels of depressive symptoms than younger children, and patients with cystic fibrosis manifested lower levels of internalizing symptoms than those with other pulmonary diseases. Findings demonstrate the resiliency of children and their parents facing a stressful point in the child's medical status and document the usefulness of psychological screening of patients and parents to identify those in need of clinical intervention.     

Shame in pastoral psychotherapy

This essay contends that pastoral psychotherapy is an arena of shame for clients and therapists. If unacknowledged, shame can undermine therapy and injure all participants. The approach is to provide a succinct typology of shame, to describe how shame is woven into the structure and process of psychotherapy, and to offer seven ways therapists can work creatively with shame in psychotherapy and turn it into a healing resource.     

Instability of individual differences in the association between confidence judgments and memory performance

There are large individual differences in the degree of association between the accuracy of memories and subjective confidence in those memories. Are these differences stable within the same test, and between alternate forms of a test? In Experiment 1, college students were tested on 3 recognition memory tasks, then retested 2 weeks later on alternate forms of the same tasks. The relationship between confidence judgments and recognition performance displayed low split-half stability and low alternate-forms stability. A second experiment with elderly adults replicated these findings. In a third experiment, college students recalled answers to general knowledge questions and rated confidence in the correctness of each answer. Individual differences in the association between confidence and recall performance were not stable across the odd- and even-numbered items on the test. These data indicate the need for the development of procedures that will produce stable estimates of individuals’ metacognitive accuracy.     

DNA markers associated with general and specific cognitive abilities

Multivariate quantitative genetic research suggests a hierarchical model of cognitive abilities where genetic effects are largely general, cutting across most cognitive abilities. Some genetic effects, however, are specific to certain cognitive abilities. These results lead to a hypothesis for molecular genetic research: Although most genes associated with one cognitive ability will be related to other cognitive abilities, some genes will be specific to a particular cognitive ability. The current research explored this hypothesis in an analysis of data in specific cognitive abilities from 86 children from 6 to 12 years of age from a larger allelic association study of general cognitive ability. Eight DNA markers were entered simultaneously in separate multiple regression analyses predicting each of four specific cognitive ability factors (Verbal, Spatial, Perceptual Speed, Memory), as well as WISC-R subtest scores. Four marjers (CTGB33, EST00083, HLA, and SOD2) showed similar effects across the cognitive ability scales, suggesting that they are related to general cognitive ability (g). These associations became negligible when the effects of ‘g’ (WISC-R IQ) were removed. Three markers (ADH5, DM, and NGFB) continued to be significantly associated with specific cognitive ability scales after the effects of ‘g’ were removed. Although preliminary, these molecular genetic results support the hierarchical model predicted by quantitative genetic research.     

Gender stereotypes in the expression and perception of vocal affect

This study examined the perception and expression of vocal affect for behavioral evidence of gender stereotypes. Subjects were 97% Caucasian and were asked to either identify or rate the effectiveness of vocal affect portrayals for 5 emotions (fear, anger, happiness, sadness, and neutral) as portrayed by 3 female and 3 male actors reading 2 stories with nonemotional word content. The results revealed that female judges identified fear, happiness, and sadness better than males. Male actors' portrayals were identified better than female actors' portrayals of anger and fear. Female actors received higher identification rates than male actors for portrayals of happiness. Partial support for the general hypothesis that there is behavioral evidence of stereotypic gender differences for vocal affect was obtained.A previous version of this article was presented at the 65th annual meeting of the Midwestern Psychological Association in Chicago, IL, during April 1993.     

Contribution of ADHD symptoms to substance problems and delinquency in conduct-disordered adolescents

We examined adolescents with conduct disorder (CD) and substance problems to determine if those with attention deficit hyperactivity disorder (ADHD) symptomatology had more severe delinquency and substance involvement. ADHD symptomatology was assessed in two ways: (1) by self-reports using the Diagnostic Interview Schedule for Children (DISC) and (2) by use of DISC plus reports of others (parents, program staff, and program teacher). We divided boys into three ADHD groups based on DISC: those who met criteria, those who reported at least eight current symptoms, and those who reported fewer than eight symptoms. We also divided the same boys into two groups: those with reports of ADHD by two or more sources and those without this multisource ADHD. Examining these definitions of ADHD revealed that boys with either self- or multisource ADHD had more CD symptoms, earlier age of CD onset, more substance dependence diagnoses, and more comorbid depression and anxiety.This investigation was supported by the National Institute on Drug Abuse Grant No. DAO6941.     

ECS disruption of avoidance produced by an air blast and tone

Rats were taught to bar press for food in a Skinner box. The amount of time needed to make 10 bar presses increased significantly after a bar press was accompanied by an air blast and loud tone. This increase did not occur if the air blast and tone were followed 8 sec later by an ECS. The technique is simple and effective, and preserves the previously established effects of ECS on recent memory. Hopefully it will prove useful in situations where the investigator wishes to establish a one-trial passive avoidance without the use of painful shock.