Antipsychotic dose modulates behavioral and neural responses to feedback during reinforcement learning in schizophrenia

Schizophrenia is characterized by an abnormal dopamine system, and dopamine blockade is the primary mechanism of antipsychotic treatment. Consistent with the known role of dopamine in reward processing, prior research has demonstrated that patients with schizophrenia exhibit impairments in reward-based learning. However, it remains unknown how treatment with antipsychotic medication impacts the behavioral and neural signatures of reinforcement learning in schizophrenia. The goal of this study was to examine whether antipsychotic medication modulates behavioral and neural responses to prediction error coding during reinforcement learning. Patients with schizophrenia completed a reinforcement learning task while undergoing functional magnetic resonance imaging. The task consisted of two separate conditions in which participants accumulated monetary gain or avoided monetary loss. Behavioral results indicated that antipsychotic medication dose was associated with altered behavioral approaches to learning, such that patients taking higher doses of medication showed increased sensitivity to negative reinforcement. Higher doses of antipsychotic medication were also associated with higher learning rates (LRs), suggesting that medication enhanced sensitivity to trial-by-trial feedback. Neuroimaging data demonstrated that antipsychotic dose was related to differences in neural signatures of feedback prediction error during the loss condition. Specifically, patients taking higher doses of medication showed attenuated prediction error responses in the striatum and the medial prefrontal cortex. These findings indicate that antipsychotic medication treatment may influence motivational processes in patients with schizophrenia.     

Concurrent adaptation to opposite visual distortions: impairment and cue

The present study compared single and dual adaptation to visuomotor rotations in different cueing conditions. Participants adapted either to a constant rotation or to opposing rotations (dual adaptation) applied in an alternating order. In Experiment 1, visual and corresponding postural cues were provided to indicate different rotation directions. In Experiment 2, either a visual or a postural cue was available. In all cueing conditions, substantial dual adaptation was observed, although it was attenuated in comparison to single adaptation. Analysis of switching costs determined as the performance difference between the last trial before and the first trial after the change of rotation direction suggested substantial advantage of the visual cue compared to the postural cue, which was in line with previous findings demonstrating the dominance of visual sense in movement representation and control.     

Uncovering unknown unknowns: Towards a Baconian approach to management decision-making

Bayesian decision theory and inference have left a deep and indelible mark on the literature on management decision-making. There is however an important issue that the machinery of classical Bayesianism is ill equipped to deal with, that of “unknown unknowns” or, in the cases in which they are actualised, what are sometimes called “Black Swans”. This issue is closely related to the problems of constructing an appropriate state space under conditions of deficient foresight about what the future might hold, and our aim is to develop a theory and some of the practicalities of state space elaboration that addresses these problems. Building on ideas originally put forward by Bacon (1620), we show how our approach can be used to build and explore the state space, how it may reduce the extent to which organisations are blindsided by Black Swans, and how it ameliorates various well-known cognitive biases.     

Levels of Family Systems Thinking: Differences Between Chinese and German Therapists

This study compares levels of systemic thinking between Chinese and German systemic family therapists when conceptualizing a clinical case. Furthermore, it explores the relationships between levels of systemic thinking and several variables of clinical training and practice. Eighty-two Chinese and seventy-six German systemic family therapists participated in this study. Significant differences in levels of systemic thinking and significant predictors for these levels were found. Limitations of this study and implications for future research and clinical practice are discussed. This study is one of the first to compare the case conceptualizations between systemic family therapists in China and Germany.     

Carryover effect of joint attention to repeated events in chimpanzees and young children

Gaze following is a fundamental component of triadic social interaction which includes events and an object shared with other individuals and is found in both human and nonhuman primates. Most previous work has focused only on the immediate reaction after following another’s gaze. In contrast, this study investigated whether gaze following is retained after the observation of the other’s gaze shift, whether this retainment differs between species and age groups, and whether the retainment depends on the nature of the preceding events. In the social condition, subjects (1- and 2-year-old human children and chimpanzees) witnessed an experimenter who looked and pointed in the direction of a target lamp. In the physical condition, the target lamp blinked but the experimenter did not provide any cues. After a brief delay, we presented the same stimulus again without any cues. All subjects looked again to the target location after experiencing the social condition and thus showed a carryover effect. However, only 2-year-olds showed a carryover effect in the physical condition; 1-year-olds and chimpanzees did not. Additionally, only human children showed spontaneous interactive actions such as pointing. Our results suggest that the difference between the two age groups and chimpanzees is conceptual and not only quantitative.     

Role of Political Skill in Job Performance Prediction Beyond General Mental Ability and Personality in Cross‐Sectional and Predictive Studies1

Political skill is the capacity to understand others in working life effectively, and to apply such knowledge to induce others to act in ways that add to one's personal or organizational goals. The present investigation reported the results of 2 studies designed to examine the job performance prediction effectiveness of political skill when investigated in conjunction with general mental ability (GMA) and personality characteristics. The results demonstrated that political skill accounted for a significant proportion of job performance variance beyond GMA and personality variables cross‐sectionally in Study 1, and predictively (i.e., using a 1‐year timeframe) in Study 2 examining effects on multiple dimensions of job performance. The implications of these results, strengths, limitations, and directions for future research are discussed.